Mesoporous silica matrix composite microsphere with efficient coagulation function and preparation method thereof

A technology of mesoporous silica and composite microspheres, which is applied in the field of biomedical materials, can solve the problems affecting hemostasis, tissue repair performance, damage to the health of workers, adhesion and blocking of bleeding sites, etc., and achieves the preparation cycle The effect of shortening, eliminating polluting dust and sealing adhering wounds

Inactive Publication Date: 2018-07-31
EAST CHINA UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The silica-based hemostatic agent manufactured by the traditional method only achieves the purpose of hemostasis by absorbing water and concentrating blood components. It cannot adhere well to block the bleeding site and reduce the amount of bleeding, which affects its hemostasis and ti

Method used

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  • Mesoporous silica matrix composite microsphere with efficient coagulation function and preparation method thereof
  • Mesoporous silica matrix composite microsphere with efficient coagulation function and preparation method thereof
  • Mesoporous silica matrix composite microsphere with efficient coagulation function and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0054] The specific preparation process includes the preparation of mesoporous powder, the formation of microspheres and the drying steps.

[0055] Powder preparation: dissolve silicon sources such as ethyl orthosilicate or sodium silicate and surfactants in 1-10% hydrochloric acid / ammonia aqueous solution, the pH of the system is 1-12, and the temperature is controlled at 30-60℃, 100 -200 revolutions / min stirring for 2-6 hours, the solution is solized and then gelled to form a gel. The gel is collected by suction filtration and then calcined to remove the surfactant to form a mesoporous structure.

[0056] Microsphere molding: According to the type of granulating agent, determine the amount of mesoporous silica powder and the type and amount of foaming pore-forming agent, mix the above ingredients with water uniformly; and drip at a rate of 30-90 drops / min In an acidic or alkaline solution, the porous silicon-based composite hemostatic microspheres formed by the mutual reaction of...

Example Embodiment

[0089] Example 1

[0090] This example relates to the synthesis of mesoporous silica powder

[0091] Prepare 280 mL of 3% hydrochloric acid aqueous solution, add 1.24 g of surfactant P123, stir until clear, pH is 2-4, add 18.37 mL of ethyl orthosilicate TEOS dropwise, stir at 60°C at 500 rpm for 2 hours, the reaction is complete The sample was collected by filtration and calcined in a muffle furnace at 600°C for 6 hours to obtain mesoporous silica powder.

Example Embodiment

[0092] Example 2

[0093] This example relates to the synthesis of mesoporous silica powder

[0094] Prepare 280mL of 5% ammonia water solution, add 1.08g cetyltrimethylammonium bromide (CTAB), stir until clear, pH is 8-10, add 18.37mL ethyl orthosilicate TEOS dropwise, 60℃ Stir at 500 revolutions per minute for 2 hours. After the reaction, the sample is collected by filtration and calcined in a muffle furnace at 600° C. for 6 hours to obtain mesoporous silica powder.

[0095] Using a transmission electron microscope (HRTEM, JEM-2100, Japan) to observe the morphology and mesoporous structure of the prepared mesoporous silica powder, the results are as follows figure 1 As shown, it is proved that the prepared silica powder has an ordered mesoporous structure.

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PUM

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Abstract

The invention discloses a mesoporous silica matrix composite microsphere with an efficient coagulation function and a preparation method thereof. The mesoporous silica matrix composite microsphere comprises mesoporous silica and natural polysaccharide, and the diameter of the mesoporous silica matrix composite microsphere is 0.2-5 millimeters. A granulation solution containing the weight ratio of100:800-3000:5-200:5-50 of mesoporous silica, water, natural polysaccharide and foaming pore forming agent is dropped into a consolidation liquid to obtain the mesoporous silica matrix composite microsphere. The preparation process is simple and efficient, granulation forming and secondary pore-forming are carried out to eliminate the problems of dust, noise pollution and high energy consumption in secondary calcining during former granulation, the preparation period of products is shortened, and the utilization of equipment is improved. The composite microsphere has functions of quick coagulation, sealing and sticking wounds, reducing bleeding amount and the like, can be applied to the fields of tissue engineering, skin regeneration and the like, and has great clinical application value.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to a mesoporous silicon-based composite hemostatic microsphere with rapid and efficient coagulation function and a preparation method thereof. Background technique [0002] Traumatic hemorrhage is one of the most common injuries in battlefields and various accident scenes, and uncontrolled bleeding is the primary cause of casualty death at the scene. Even if the wounded can be sent to the hospital for rescue, massive blood loss before the hospital will still cause higher mortality and serious complications (such as amputation, etc.) in the later stage. Therefore, it is of great significance to effectively control the bleeding of the wounded at the scene and before the hospital. In fact, most casualties from bleeding were preventable. The tourniquet is a life-saving device that can control bleeding, but it cannot be used or is invalid for many parts of the human body ...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61L27/60A61L27/02A61L27/20
CPCA61L26/0004A61L26/0023A61L26/0061A61L26/0085A61L27/025A61L27/20A61L27/60A61L2400/04C08L5/08C08L5/04
Inventor 袁媛刘昌胜洪华周华溢王成伟
Owner EAST CHINA UNIV OF SCI & TECH
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