Unlock instant, AI-driven research and patent intelligence for your innovation.

POSS/PNIPAM nanocomposite with reversible sol-gel transition as well as preparation method and application thereof

A nano-composite material and gel technology, which is applied in non-active ingredients medical preparations, pharmaceutical formulations, medical science and other directions, can solve the problems of limited application and low mechanical strength of PNIPAM gel, and achieves improved mechanical properties and preparation methods. and the effect of simple craftsmanship

Inactive Publication Date: 2018-08-07
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical strength of PNIPAM gel itself is not high, which limits its further application. Therefore, literature reports improve its mechanical properties by introducing nano-enhancers, including nanoclay, carbon nanotubes and graphene.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • POSS/PNIPAM nanocomposite with reversible sol-gel transition as well as preparation method and application thereof
  • POSS/PNIPAM nanocomposite with reversible sol-gel transition as well as preparation method and application thereof
  • POSS/PNIPAM nanocomposite with reversible sol-gel transition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Synthesis of OCAPS: Add 150 mL of 3-aminopropyltriethoxysilane (silane coupling agent KH550) into 1000 mL of anhydrous methanol under magnetic stirring conditions, and after mixing well, slowly add 135 mL of concentrated hydrochloric acid to the mixture , the acid hydrolysis reaction was continued at room temperature for about two weeks, and after the reaction was completed, a white solid product was obtained by suction filtration. After vacuum drying at 40°C for 24 hours, the product OCAPS was obtained with a yield of 15%.

Embodiment 2

[0026] Preparation of 1% OCAPS / PNIPAM (the molar ratio of the two is 1%) nanocomposite: Weigh 0.05g (4.28×10 -5 mol) OCAPS and 0.4822g (4.26×10 -3 mol) NIPAM was dissolved in a container of 4mL (0.22mol) deionized water, and after complete dissolution, 0.0106g initiator potassium peroxodisulfate (KPS) and 0.0021g catalyst N,N,N',N'-tetramethylethane were added Diamine (TEMED), through nitrogen deoxygenation, put it into 37 o C reacted in a constant temperature water bath for 24 hours, then took out the material and put it in 37 o Soak C in deionized water for 5 minutes to remove unreacted monomers, initiators and catalysts to obtain the product.

Embodiment 3

[0028] Preparation of 3% OCAPS / PNIPAM (the molar ratio of the two is 3%) nanocomposite: Weigh 0.15g (1.28×10 -4 mol) OCAPS and 0.4822g NIPAM (4.26×10 -3 mol) dissolved in 4mL (0.22mol) of deionized water container, after complete dissolution, add 0.0095g initiator potassium peroxodisulfate (KPS) and 0.0019g catalyst N,N,N',N'-tetramethylethylenedi Amine (TEMED), through nitrogen deoxygenation, put the reaction vessel into 37 o C reacted in a constant temperature water bath for 24 hours, then took out the material and put it in 37 o Soak C in deionized water for 5 minutes to remove unreacted monomers, initiators and catalysts to obtain the product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a POSS / PNIPAM nanocomposite with reversible sol-gel transition as well as a preparation method and application thereof. The preparation method comprises the following steps: selecting water soluble polyhedral oligomeric silsesquioxane (POSS), enabling N-isopropyl acrylamide to be subjected to in situ polymerization in aqueous solution of POSS, and carrying out physical crosslinking by utilizing interaction of statics or hydrogen bonds among POSS and PNIPAM molecular chains, so that the POSS / PNIPAM nanocomposite is generated. The prepared POSS / PNIPAM nanocomposite has temperature sensitivity, is flowable sol at room temperature and is solid-state gel at the temperature of 37 DEG C, and the process is reversible, so that the nanocomposite has injectability. The POSS is added, so that viscosity and gelatinization time of a PNIPAM system can be regulated, and mechanical properties of PNIPAM are greatly improved. The nanocomposite is simple in the preparation method,environment-friendly and applicable to large-scale preparation and can be applied to the field of biomedical materials.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to a POSS / PNIPAM nanocomposite material with reversible sol-gel transition. Background technique [0002] In recent years, among various biomaterials, injectable hydrogels formed by in situ chemical polymerization or sol-gel transition methods have received extensive attention. Thermosensitive hydrogels are particularly attractive as a class of injectable biomaterials because they can spontaneously gel under the influence of body temperature without any additional chemical treatment. These materials are fluid prior to injection and, once injected, rapidly form gels at physiological temperatures. The main advantages of injectable hydrogels are: the injection matrix only needs a small surgical wound during implantation into the human body, and drug molecules or cells can be mixed with the matrix before injection to gel in situ in the human body. After melting, the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08L33/24C08L83/04C08F120/54A61K47/34A61K9/06A61L27/26A61L27/50A61L27/52A61L31/04A61L31/14
Inventor 张晓静沈炜炜窦竞成陈正阳方少明
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com