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Composition capable of reducing uric acid

A composition and uric acid-lowering technology, applied in the direction of drug combination, plant raw materials, plant/algae/fungus/moss components, etc., to achieve significant curative effect, restore kidney function, and reduce the production of uric acid

Active Publication Date: 2018-08-10
武汉华裕新美菌业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant literature on the treatment of gout after combination

Method used

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  • Composition capable of reducing uric acid
  • Composition capable of reducing uric acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Preparation of Rapeseed Pollen Alcoholic Extract

[0021] Take the rapeseed pollen after the wall-breaking treatment, extract with 75% ethanol, concentrate the extract under reduced pressure until there is no ethanol; extract the extract with n-butanol saturated with water until the n-butanol layer is colorless, and depressurize Concentrate the n-butanol layer and vacuum freeze-dry to obtain the crude rape pollen extract; dissolve the crude extract in water and put it on the AB-8 macroporous adsorption resin column, wash it with water until the eluent is not turbid, and then use 50% Eluted with ethanol, collected the ethanol eluate, concentrated under reduced pressure, and vacuum freeze-dried to obtain rapeseed pollen extract.

[0022] (2) Preparation of purple sweet potato alcohol extract

[0023] Extract the purple sweet potato powder with 60% ethanol, concentrate the extract under reduced pressure until there is no ethanol; extract the extract with ethyl acetate...

Embodiment 2

[0028] The inhibitory effect of embodiment 2 composition on XO

[0029] (1) Test method

[0030] Xanthine oxidase (XO) catalyzes xanthine (Xan) to produce uric acid and has a characteristic absorption peak at 290nm. The kinetics / time software of the ultraviolet spectrophotometer is used to measure the absorbance every 15s, and it is measured 20 times in total. The absorbance increases linearly with time, and its slope is the reaction rate of the enzyme. The larger the slope, the stronger the activity of the enzyme.

[0031] First, the alcoholic extract of rape pollen, the alcoholic extract of purple sweet potato, the aqueous extract of Auranthus clematis and the composition prepared in Example 1 were respectively dissolved in 1% DMSO to prepare sample solutions of different concentrations, and then 100 μL of 7.5×10 -8 mol / L XO solution and 50 μL sample solution were mixed, incubated at 37°C for 5 min, and then 100 μL of substrate solution Xan (5×10 -5 mol / L) to start the re...

Embodiment 3

[0036] Embodiment 3 composition lowers uric acid effect evaluation

[0037] (1) Test method

[0038] The hyperuricemia mouse model was established by using the uricase inhibitor oxonate potassium to induce hyperuricemia. Firstly, Kunming male mice were randomly divided into 7 groups, namely: the blank control group, the model group, and the rape pollen alcohol extract group (200mg / kg bw), purple sweet potato alcohol extract group (200mg / kg bw), clematis water extract group (200mg / kg bw), composition group (200mg / kg bw), allopurinol positive control group (5 mg / kg·bw), 10 mice in each group. Under the condition of ensuring normal diet and drinking water, oxonate potassium / carboxymethylcellulose sodium suspension was administered to the mice in the model group for 7 consecutive days at a dose of 250 mg / kg·d to establish hyperuricemia in mice animal models. The mice in the blank control group were given the same concentration of CMC-Na solution. At the end of the day, after ...

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Abstract

The invention discloses a composition capable of reducing uric acid. The composition is composed of rape pollen alcohol extracts, purple sweet potato extracts and anoectochilus formosanus water extracts. It is proved by an in-vivo animal experiment result that the composition has the effects of reducing uric acid, recovering the renal function, accelerating discharging of uric acid, decreasing generation of uric acid and the like and is a drug which is remarkable in treatment effect and high in safety and is used for treating gout.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a composition for reducing uric acid. Background technique [0002] Gout is a group of metabolic diseases caused by purine metabolic disorders and / or uric acid excretion disorders. Urate deposition in joints can induce recurrent gouty acute arthritis, tophi deposition, and joint deformities. The kidneys of patients with severe gout will also be damaged, such as causing uric acid kidney stones and chronic interstitial nephritis. Hyperuricemia is the main biochemical basis of gout, and it is the "fourth highest" after hypertension, hyperglycemia, and hyperlipidemia, which seriously endangers human health. Many studies have shown that hyperuricemia is closely related to diabetes, hypertension, obesity, coronary heart disease, and chronic kidney disease. The latest epidemiological survey results show that in recent years, with the improvement of people's living standards and changes in lifesty...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K36/39A61P19/06
CPCA61K36/185A61K36/31A61K36/39A61K36/898A61K2236/331A61K2236/333A61P19/06A61K2300/00
Inventor 张久亮杨紫薇
Owner 武汉华裕新美菌业有限公司
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