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A double-gradient artificial lamina and its preparation method

A dual-gradient, artificial technology, applied in the field of biomedical materials, can solve the problems of insufficient compatibility and anti-adhesion, poor new bone formation ability, and no osteoinductivity, etc., to achieve good osteoconduction and osteoinductivity, Good soft tissue compatibility and anti-adhesion ability, excellent osteoinductive effect

Active Publication Date: 2020-11-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the materials of artificial lamina generally include stainless steel, titanium or titanium alloy, bioactive ceramics, active glass, etc., but the above-mentioned artificial lamina has insufficient histocompatibility and anti-adhesion, and is not osteoinductive or osteoinductive. , leading to poor new bone formation

Method used

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  • A double-gradient artificial lamina and its preparation method
  • A double-gradient artificial lamina and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, a kind of double-gradient artificial lamina

[0029] The artificial lamina described in Example 1 is a matrix with a trapezoidal cross-section and an axial length. The matrix is ​​composed of an upper layer, a middle layer and a lower layer. The upper layer and the lower layer are hydroxyapatite ceramic layers 1, and the The middle layer is a biphasic calcium phosphate ceramic layer 2, and the upper and lower layers are dense structure layers with a thickness of 1 mm. The middle layer is a porous structure layer with a porosity of 75%.

[0030] Preparation:

[0031] A) Raw material preparation:

[0032] Preparation of nano-hydroxyapatite powder or slurry: Mix 0.835mol / L calcium nitrate aqueous solution and 0.5mol / L diammonium hydrogen phosphate aqueous solution in equal volumes, the calcium-phosphorus ratio is 1.67, adjust the pH of the solution to 11.0 with ammonia water, Stir and react for 12 hours, then age at 60°C for 24 hours, wash with deionized ...

Embodiment 2

[0038] Embodiment 2, a kind of double-gradient artificial lamina

[0039]The difference between embodiment 2 and embodiment 1 is that the binding agent described in steps B) and C) is polyethylene glycol, the dispersant is citric acid, and the pore-forming agent is polymethyl methacrylate, and the step D ) the isostatic pressure is 300MPa, and the step E) is: place the above-mentioned green body in the furnace cavity of a muffle furnace sintering furnace, use a muffle furnace for sintering, and raise the temperature at a heating rate of 0.5°C / min To 150°C, keep warm for 10min; then raise the temperature to 500°C at a heating rate of 0.5°C / min, and keep warm for 10minh; then raise the temperature to 600°C at a heating rate of 0.5°C / min, keep warm for 30min to decompose the organic matter; continue to use Sintering in a muffle furnace, heating up to 1000°C at a heating rate of 10°C / min, holding time for 1h, and lowering the temperature to room temperature at a cooling rate of ...

Embodiment 3

[0040] Embodiment 3, a kind of double-gradient artificial lamina

[0041] The difference between Example 3 and Example 1 is that the binder in steps B) and C) is polyethylene glycol, the dispersant is ammonium citrate, and the pore-forming agent is polystyrene. The isostatic pressing pressure is 500MPa, and the step E) is: place the above-mentioned green body in the furnace cavity of a muffle furnace sintering furnace, use a muffle furnace for sintering, and raise the temperature to 250°C at a heating rate of 20°C / min. ℃, hold for 2 hours; then raise the temperature to 500°C at a heating rate of 3°C / min, and hold for 4 hours; then raise the temperature to 800°C at a heating rate of 20°C / min, and hold for 4 hours to decompose organic matter; continue to use muffle Furnace sintering, heating up to 1200°C at a heating rate of 20°C / min, holding time for 4 hours, and lowering the temperature to room temperature at a cooling rate of 100°C / min; cutting to obtain artificial lamina w...

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Abstract

The invention belongs to the technical field of biomedical materials and in particular relates to a double-gradient artificial vertebral lamina and a preparation method thereof. The double-gradient artificial vertebral lamina is a base body with a trapezoid cross section and an axial length, wherein the base body is composed of an upper layer, a middle layer and a lower layer; the upper layer andthe lower layer are dense hydroxyapatite ceramic layers; the middle layer is a porous double-phase calcium phosphate ceramic layer. The artificial vertebral lamina provided by the invention has a dense / porous / dense trapezoid sandwich structure; compared with the prior art, the artificial vertebral lamina has higher tissue compatibility and anti-adhesion performance; meanwhile, the artificial vertebral lamina has excellent osteoinduction performance, is simple in structure and convenient to implant and is suitable for being popularized and applied in a large range.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a double-gradient artificial lamina and a preparation method thereof. Background technique [0002] Posterior laminectomy (including total laminectomy, half laminectomy, partial laminectomy, etc.) is the most basic and commonly used surgical operation in spinal surgery, and its scope of application covers almost all diseases of spinal surgery, especially for patients with Patients with cervical, thoracic and lumbar spinal stenosis. Although laminectomy can effectively relieve the compression of the spinal cord and nerves and alleviate the symptoms of patients, after laminectomy (loss), it loses its original protective effect on the spinal canal, and there will be a large amount of scar tissue hyperplasia in the defect area, which will extend to the spinal canal. Ingrown, and even oppressed, adhered, and stretched the spinal cord and nerve roots again, re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/12A61L27/10A61L27/56A61L27/50C04B35/447C04B35/622C04B38/06
CPCA61L27/10A61L27/12A61L27/50A61L27/56A61L2430/38C04B35/447C04B35/622C04B38/0645C04B2235/5427C04B2235/5436C04B2235/5445C04B2235/5454C04B2235/602C04B2235/656C04B2235/6562C04B2235/6565C04B2235/6567C04B2235/667C04B2235/75C04B2235/96
Inventor 朱向东吴永豪刘丹李向锋杨曦宋跃明张兴栋
Owner SICHUAN UNIV
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