Method of utilizing continuous flow microreactor to synthesize benzophenone derivative

Abstract

The invention belongs to the technical field of organic synthesis, and particularly relates to a method of utilizing a continuous flow microreactor to synthesize a benzophenone derivative. The methodincludes: using aryl Grignard reagent and acyl chloride as raw materials; at normal temperature, continuously synthesizing the benzophenone derivative in the microreactor; recycling a reaction solvent2-methyl tetrahydrofuran. Problems of environmental pollution and reaction operation safety caused by the fact that conventional Fridel-Crafts reaction is excessively dependent on reagents like aluminum trichloride, ferric trichloride and zinc dichloride are avoided, the defect that novel catalytic processes are expensive in catalytic reagent and harsh in operation condition is made up, and continuous synthesis of a medical intermediate ketoprofen nitrile is realized efficiently. The method has the advantages of high operation convenience, high reaction safety, high yield, high efficiency andreaction solvent reusability and is environment-friendly and efficient.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a method for preparing benzophenone derivatives using a continuous flow microreactor. Background technique [0002] Benzophenone and its derivatives are an important class of fine chemical intermediates, which are widely used in the fields of medicine, pesticides, dyes, plastics, coatings, daily chemicals and electronic chemicals. For example, 5-acetyl-2-aminobenzophenone is an important intermediate in drug synthesis; sulfur-containing benzophenone is a good photoinitiator and can be miscible with many monomers and copolymers; 2 -Amino-4-bromobenzophenone is used as a plant growth regulator and at the same time as a synthetic drug for the treatment of ophthalmic inflammation; -5-Chlorobenzophenone is a stabilizing pharmaceutical intermediate; 4-Chlorobenzophenone is used in the production of antiallergic drug Anqimin, etc. The traditional synthesis method...

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Problems solved by technology

[0004] In order to solve the problems of the technologies described above, the purpose of this invention is to provide a method for the preparation of benzophenone derivatives in a continuous flow microreactor, to overcome the existing aryl Grignard reagents and acid chlorides in the synthesis of benzophenone derivatives method. There are problems such as severe heat release, difficult operation control, harsh equipment requirements, significant "magnification effect", and low yield.

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