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Injectable polymer hydrogel based on acylhydrazone bond, preparation method thereof and polymer hydrogel injection

A polymer hydrogel, acylhydrazone bond technology, applied in pharmaceutical formulations, pharmaceutical sciences, prostheses, etc., can solve the problem of mechanical strength, structure and comprehensive performance cannot be unified and jointly improved, complex composition and structure, poor fluidity, etc. problem to achieve excellent injectability

Active Publication Date: 2018-09-04
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the application of polymer hydrogel in soft tissue repair has received extensive attention and research, but its composition and structure are complex, and there are also challenges such as mechanical strength, structure and comprehensive performance that cannot be unified and improved together, and its fluidity is poor.

Method used

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  • Injectable polymer hydrogel based on acylhydrazone bond, preparation method thereof and polymer hydrogel injection
  • Injectable polymer hydrogel based on acylhydrazone bond, preparation method thereof and polymer hydrogel injection
  • Injectable polymer hydrogel based on acylhydrazone bond, preparation method thereof and polymer hydrogel injection

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preparation example Construction

[0042] The present invention also provides a method for preparing an injectable polymer hydrogel based on an acylhydrazone bond, which includes:

[0043] Step 110, component 1 obtained by introducing a hydrazide group into a polysaccharide polymer through a chemical modification method;

[0044] Step 112, introducing aldehyde groups into polyvinyl alcohol, hydroxyl-terminated polyethylene glycol, and / or polyethylene oxide-polyoxypropylene-polyoxyethylene by chemical modification to obtain component 2;

[0045] Step 114, at room temperature, mix component 1 and component 2 with water solvent according to a preset ratio to obtain mixture 1 and mixture 2;

[0046] Step 116, mix the mixture 1 and the mixture 2, stir and gel evenly.

[0047] Normal temperature is mentioned in step 114, that is, the natural temperature without adding any temperature adjustment disturbance factors. Temperature values ​​in the range of 22-37°C are preferred.

[0048] The present invention also prov...

Embodiment 1

[0051] Dissolve 1.0 g of hydrazide-modified sodium alginate (Alg-HZ) and aldehyde-modified poloxamer (PVA-AH) 1.0 g in 10 mL of aqueous solution, shake and mix the two to obtain water A gel precursor solution that gradually cross-links into a hydrogel over time.

Embodiment 2

[0053] Dissolve 1.0 g of hydrazide-modified sodium hyaluronate (HA-HZ) and aldehyde-modified poloxamer (PVA-AH) 1.0 g in 10 mL of aqueous solution, shake and mix the two evenly to obtain A hydrogel precursor solution that gradually cross-links into a hydrogel over time.

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Abstract

The invention relates to the field of hydrogel preparation, in particular to injectable polymer hydrogel based on an acylhydrazone bond, a preparation method thereof and a polymer hydrogel injection.The injectable polymer hydrogel based on the acylhydrazone bond comprises the raw materials of a first component obtained by modifying a hydrazide-based polysaccharide polymer, and a second componentobtained by modifying aldehyde-based polyvinyl alcohol, terminal-hydroxyl-based polyethylene glycol, and / or polyethylene oxide-polypropylene oxide-polyethylene oxide. The adding mass ratio of the first component and the second component meets that the range of hydrazide-based substitution degree / aldehyde-based substitution degree is 20-80%, and the balance water solvent is added. Very high fluidity is achieved within a few minutes after prepolymers of the first component and the second component are well mixed, and the prepolymers can be immediately injected to a specific mould or position tobe formed; if the prepolymers of the first component and the second component are mixed and subjected to gelatination, the injectable property is still achieved; the first component and the second component both have very excellent structure compatibility; and the certain fluidity is shown after the first component and the second component are mixed.

Description

technical field [0001] The invention relates to the field of hydrogel preparation, in particular to an injectable polymer hydrogel based on an acylhydrazone bond, a preparation method thereof and a polymer hydrogel injection. Background technique [0002] Injectable polymer hydrogel generally refers to a special type of polymer hydrogel, which often has the property of shear thinning, can flow when subjected to external force, and has certain mechanical properties after removing the external force. Injectable hydrogels still have the basic characteristics of polymer hydrogels. The components of injectable polymer hydrogel include natural polymer components such as alginic acid, hyaluronic acid, chitosan, cellulose, starch, collagen, gelatin, polylysine, or polyethylene glycol, poly Vinyl alcohol, polyacrylic acid, polyacrylamide, hydrophilic modified polycaprolactone, polylactic acid and other synthetic polymer components, or complexes of multiple components, through dynami...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/52A61L27/20A61L27/18A61L27/16
CPCA61L27/16A61L27/18A61L27/20A61L27/26A61L27/52A61L2400/06A61L2430/34C08L71/02C08L29/04
Inventor 李自伊李志勇陈永明刘利新林思羽梁家升
Owner SUN YAT SEN UNIV
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