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Biomedical hydrogel coating layer with 'sandwich' structure and preparation method of biomedical hydrogel coating layer

A sandwich structure, biomedical technology, applied in the field of medical materials, can solve the problems of poor film stability and fast drug release rate, and achieve the effect of improving binding force, good interface binding force, and improving structural stability

Active Publication Date: 2018-09-07
JILIN VENUS HAOYUE MEDICAL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the above prior art, the present invention provides a biomedical hydrogel coating with a "sandwich" sandwich structure and its preparation method to solve the technical problems of poor film stability and excessive drug release rate

Method used

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  • Biomedical hydrogel coating layer with 'sandwich' structure and preparation method of biomedical hydrogel coating layer
  • Biomedical hydrogel coating layer with 'sandwich' structure and preparation method of biomedical hydrogel coating layer
  • Biomedical hydrogel coating layer with 'sandwich' structure and preparation method of biomedical hydrogel coating layer

Examples

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Effect test

Embodiment 1

[0032] A method for preparing a biomedical hydrogel coating with a "sandwich" sandwich structure, obtained by the following steps:

[0033] A. Clean and dry the silicon wafers to be modified;

[0034] B. Place the sample obtained in step A in PBS buffer solution with pH = 8.5, then add dopamine with a concentration of 3 mg / ml into the solution, react at 10°C for 2 hours, wash with deionized water for 3 to 5 times, and N 2 Dried and immediately put into a vacuum drying oven for future use;

[0035] C. First put the sample obtained in step B into a chitosan (CHI) solution with a concentration of 1mM and pH=7.4, react for 10min at 20°C, take it out and wash it with deionized water for 3 times; then put the sample into In an epigallocatechin gallate (EGCG) solution with a concentration of 0.2mM and pH=7.0, react at 10°C for 10min, take it out and wash it with deionized water for 3 times; then put the sample in a concentration of 0.2mM , in an anti-lymphocyte immunoglobulin (ALg...

Embodiment 2

[0038] A method for preparing a biomedical hydrogel coating with a "sandwich" sandwich structure, obtained by the following steps:

[0039] A. Clean and dry the stainless steel base material;

[0040] B. Place the sample obtained in step A in Tris-HCl buffer solution with pH = 8.5, then add dopamine with a concentration of 1.2 mg / ml into the solution, react for 2 hours at 20°C, and wash with deionized water for 3 to 5 times after N 2 Dried and immediately put into a vacuum drying oven for future use;

[0041] C. First put the sample obtained in step B into a chitosan (CHI) solution with a concentration of 0.01mM and pH=6, react for 30min at 10°C, take it out and wash it with deionized water for 3 times; then the obtained sample Put it into a gallic acid solution with a concentration of 0.01mM and pH=5.5, react at 30°C for 5 minutes, take it out and wash it with deionized water for 3 times; then put the obtained sample into a collagen solution with a concentration of 0.01mM a...

Embodiment 3

[0044] A method for preparing a biomedical hydrogel coating with a "sandwich" sandwich structure, obtained by the following steps:

[0045] A, the titanium sheet material is cleaned and dried;

[0046] B. Place the sample obtained in step A in a triethanolamine buffer solution with pH = 8, then add dopamine at a concentration of 2.0 mg / ml to the solution, react for 4 hours at 10°C, and wash with deionized water for 3 to 5 times via N 2 Dried and immediately put into a vacuum drying oven for future use;

[0047] C. First put the sample obtained in step B into a lysine solution with a concentration of 2mM and pH=7.4, react at 50°C for 4min, take it out and wash it with deionized water for 3 times; then put the sample into a lysine solution with a concentration of 1mM , pH = 6.8 epigallocatechin gallate (EGCG) solution, under the condition of 10 ℃, reacted for 20min, took out and washed 3 times with deionized water; then put the sample into 1mM, pH = 6.8 polyphenylene In sodiu...

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Abstract

The invention discloses a biomedical hydrogel coating layer with a 'sandwich' structure and a preparation method of the biomedical hydrogel coating layer. The preparation method comprises the following steps: firstly cleaning and drying a to-be-modified base material; putting the processed base material into a buffer solution, adding dopamine into the solution, and reacting at 10-30 DEG C for 0.5-4 hours; sequentially putting the reacted base material into a polypositive electrolyte solution, a polyphenol compound solution and a polynegative electrolyte solution for reaction, so as to finish areaction cycle; and finally, repeatedly carrying out the reaction cycle for 10-200 times, so as to obtain a final product. By virtue of the preparation method, the biomedical hydrogel coating layer with excellent mechanical properties and low drug release speed can be prepared, and the technical problems that a film is poor in stability and over high in drug release speed can be effectively solved.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a biomedical hydrogel coating with a "sandwich" sandwich structure and a preparation method thereof. The coating can be used for surface modification of cardiovascular, orthopedic and other medical devices. Background technique [0002] In 1966, Iler et al first reported the method of obtaining ultra-thin films by alternating adsorption, that is, "layer-by-layer self-assembly". The layer-by-layer self-assembly technology is mainly based on non-covalent bond interactions such as hydrogen bonds, host-guest interactions, coordination bonds, electrostatic interactions, and molecular recognition interactions. It has the characteristics of simple sample preparation and controllable number of film layers. Commonly used layer-by-layer assembly components include materials such as polyelectrolytes, nanoparticles, micellar vesicles, and proteins, which can be formed i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L31/16
CPCA61L31/10A61L31/14A61L31/145A61L31/16A61L2300/216A61L2300/41A61L2300/606A61L2400/18A61L2420/06A61L2420/08C08L5/08
Inventor 罗日方王云兵
Owner JILIN VENUS HAOYUE MEDICAL LTD
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