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Preparation method and application of antibacterial medical material

An antibacterial and reactive technology, applied in the field of preparation of antibacterial medical materials, can solve the problems of high mortality, medical infection accidents, repeated infections, etc., and achieve good biocompatibility, improved performance, and excellent antibacterial effect. Effect

Inactive Publication Date: 2018-09-07
苏州凌科特新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the protective effect of the biofilm, the bacteria in the film will continue to multiply and release planktonic bacteria, causing repeated or worsening infections, and medical infection accidents are prone to occur; medical infections not only cause high mortality, but also cause serious harm to patients, hospitals and Society carries a heavy burden of disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Put 3 parts of light calcium carbonate and 2 parts of magnesium borate whiskers into the ball mill, and then add an ethanol solution with a concentration of 95% twice the mass of the solid mixture to carry out wet ball milling. The ball-to-material ratio of the ball mill is 10 : 1, the ball milling speed is 500 rev / s, the ball milling time is 60 minutes, then the mixed powder obtained by the ball milling process is placed in a vacuum drying oven and dried at a temperature of 60°C for 6 hours to obtain a dry mixed powder;

[0025] (2) Add 35 parts of polyamide resin and 30 parts of ethylene bis stearic acid amide into the vacuum reactor, evacuate to -0.08MPa, set the temperature in the reactor to 160°C, and stir at 150 rpm The high-temperature stirring reaction was carried out at a high speed, and the reaction time was 45 minutes. Then, the temperature in the reactor was lowered to 120°C, and 8 parts of N,N-dimethyl-p-aniline were added, stirred evenly at a stirring s...

Embodiment 2

[0032] (1) Put 4 parts of light calcium carbonate and 3 parts of magnesium borate whiskers into the ball mill, and then add an ethanol solution with a concentration of 95% of the solid mixture twice the mass for wet ball milling. The ball-to-material ratio of the ball mill is 10 : 1, the ball milling speed is 500 rpm, the ball milling time is 75 minutes, then the mixed powder obtained by ball milling is placed in a vacuum drying oven and dried at a temperature of 65°C for 7 hours to obtain a dry mixed powder;

[0033](2) Add 40 parts of polyamide resin and 35 parts of ethylene bis stearic acid amide into the vacuum reactor, vacuumize to -0.09MPa, set the temperature in the reactor to 170°C, and stir at 155 rpm The high-temperature stirring reaction was carried out at a high speed, and the reaction time was 50 minutes. Then, the temperature in the reactor was lowered to 120°C, and 10 parts of N,N-dimethyl-p-aniline was added, stirred evenly at a stirring speed of 155 rpm, and th...

Embodiment 3

[0040] (1) Put 5 parts of light calcium carbonate and 4 parts of magnesium borate whiskers into the ball mill, and then add an ethanol solution with a concentration of 95% of the solid mixture twice the mass for wet ball milling. The ball-to-material ratio of the ball mill is 10 : 1, the ball milling speed is 500 rev / s, the ball milling time is 90 minutes, then the mixed powder obtained by the ball milling process is placed in a vacuum drying oven and dried at a temperature of 70°C for 8 hours to obtain a dry mixed powder;

[0041] (2) Add 45 parts of polyamide resin and 40 parts of ethylene bis stearic acid amide into the vacuum reactor, vacuumize to -0.1MPa, set the temperature in the reactor to 180°C, and stir at 160 rpm The high-temperature stirring reaction was carried out at a high speed, and the reaction time was 55 minutes. Then, the temperature in the reactor was lowered to 120°C, and 12 parts of N,N-dimethyl-p-aniline were added, and the stirring speed was 160 rpm. P...

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PUM

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Abstract

The invention discloses a preparation method and application of an antibacterial medical material. The preparation method comprises the following steps: ball milling light calcium carbonate and magnesium borate whiskers in a wet method, and drying to obtain dry mixed powder; performing the high-temperature stirring reaction for polyamide resin and ethylidene amine distearate in a vacuum reaction kettle, cooling, adding N,N-dimethyl-p-toluidine, standing, preserving the heat, reacting, obtaining a high-temperature reactant, cooling, adding dodecyl dimethyl amine oxide, trisodium citrate and chitosan fibers, and pressurizing reacting in a nitrogen environment to obtain a secondary reactant; and then mixing and stirring the dry mixed powder, the secondary reactant and additives to obtain a thermal mixture, adding dimethyl sulfoxide, and preparing a finished product medical material by virtue of the process of ultrasonic treatment, extrusion granulating, injection molding, segmenting, packaging, sterilizing and the like. The prepared medical material is excellent in antibacterial effect, good in bio-compatibility and good in application prospect on medical equipment.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a preparation method and application of an antibacterial medical material. Background technique [0002] Medical materials refer to a class of materials with special properties and special functions, which are used for artificial organs, surgical repair, physiotherapy rehabilitation, diagnosis and treatment of diseases, and do not have adverse effects on human tissues. Among them, the most widely used category is medical polymer materials, specifically referring to polymer materials used to manufacture human internal organs, external organs, pharmaceutical dosage forms and medical devices. Its sources include natural biopolymer materials and synthetic biopolymer materials. Natural medical polymer materials come from nature, including cellulose, chitin, hyaluronic acid, collagen, gelatin and sodium alginate, etc.; synthetic medical polymer materials are chemically synth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L77/00C08L5/08C08K3/26C08K7/08C08K5/20C08K5/18C08K13/04C08K5/098
CPCC08K2003/265C08L77/00C08L5/08C08K3/26C08K7/08C08K5/20C08K5/18C08K13/04C08K5/098
Inventor 李子寅
Owner 苏州凌科特新材料有限公司
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