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Medical chitosan sterilization spray

A technology of chitosan and polyvinyl alcohol, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, antibacterial drugs, etc. Negative bacteria have weak antibacterial properties and limited absorption of osmotic fluid, achieving the effect of easy mass production, simple method, and reducing scar formation

Active Publication Date: 2018-10-09
宁波科瑞特动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are some antibacterial materials based on chitosan, but there are still some problems. Generally, natural chitosan with a relative molecular mass of more than 100,000 has poor water solubility and weak antibacterial properties against Gram-negative bacteria. The surface film formed by it is generally dense, which affects the air permeability between the wound and the outside world and the comfort of the user; on the other hand, the medical liquid dressing made of chitosan is generally used for small wounds, and its absorption of permeate is limited. , will greatly affect wound healing

Method used

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preparation example Construction

[0095]The preparation method of the polyvinyl alcohol of described carboxylation is:

[0096] Take a certain amount of polyvinyl alcohol, carboxylic acid, concentrated sulfuric acid, and water in a reaction bottle, react at 80°C for 24 hours, wash with methanol, and vacuumize to obtain carboxylated polyvinyl alcohol.

[0097] In a preferred embodiment, the weight ratio of the concentrated sulfuric acid, water, methanol and polyvinyl alcohol is 0.1:2.5:10:100.

[0098] In a preferred embodiment, the carboxylic acid is selected from fumaric acid, terephthalic acid, pyridine-2,5-dicarboxylic acid, 4,4'-bistyryl dicarboxylic acid, 4,5 - a combination of any one or more of difluoro-2-nitrophenylacetic acid and 2-amino-5-bromopyridine-4-carboxylic acid; more preferably, the carboxylic acid is fumaric acid.

[0099] The preparation method of the polyvinyl alcohol of described carboxylation is:

[0100] Take a certain amount of polyvinyl alcohol, fumaric acid, concentrated sulfuric ...

Embodiment 1

[0126] Embodiment 1 of the present application provides a kind of chitosan medical sterilization spray, described chitosan medical sterilization spray, by weight, comprises:

[0127] Hydrophilic organic molecule—30 parts of cyclodextrin modified chitosan;

[0128] 5 parts of auxiliary agent;

[0129] 130 parts of water.

[0130] Wherein, the hydrophilic organic molecule-cyclodextrin modified chitosan is prepared from cyclodextrin grafted modified chitosan covering hydrophilic organic molecules; the relative molecular mass of the chitosan is 50000; the weight ratio of the hydrophilic organic molecule-cyclodextrin to chitosan is 6:1;

[0131] The preparation method of described hydrophilic organic molecule-cyclodextrin modified chitosan is:

[0132] 1) Chitosan and benzaldehyde are dissolved in 3% acetic acid solution in mass fraction, and reacted for 2 hours at room temperature; the reaction solution is poured into 10% sodium hydroxide-ethanol solution in mass fraction, afte...

Embodiment 2

[0161] Embodiment 2 of the present application provides a kind of chitosan medical sterilization spray, described chitosan medical sterilization spray, by weight, comprises:

[0162] Hydrophilic organic molecule—50 parts of cyclodextrin modified chitosan;

[0163] 10 parts of auxiliary agent;

[0164] 200 parts of water.

[0165] Wherein, described hydrophilic organic molecule-cyclodextrin modified chitosan is obtained by the cyclodextrin grafting modified chitosan of coating hydrophilic organic molecule; The relative molecular weight of described chitosan is 50000; the weight ratio of the hydrophilic organic molecule-cyclodextrin to chitosan is 6:1;

[0166] The preparation method of described hydrophilic organic molecule-cyclodextrin modified chitosan is identical with embodiment 1;

[0167] The weight ratio of the hydrophilic organic molecule to the cyclodextrin is 5:1; the hydrophilic organic molecule is carboxylated polyvinyl alcohol; the cyclodextrin is γ-cyclodextrin...

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Abstract

The invention relates to the technical field of medical consumables and in particular relates to chitosan sterilization spray and a preparation method thereof. A first aspect of the invention discloses the chitosan sterilization spray, and the chitosan sterilization spray at least comprises the following components in parts by weight: 5-50 parts of hydrophilic organic molecule-cyclodextrin modified chitosan, 0.3-5 parts of aids and 60-200 parts of water, wherein the aids at least comprise a collagen inhibitor, a bactericide and a penetration enhancer.

Description

Technical field: [0001] The invention relates to the technical field of medical consumables, more specifically, the invention relates to a chitosan medical sterilization spray and a preparation method thereof. Background technique: [0002] Wounds can be defined as skin defects caused by mechanical, electrical, thermal, chemical and other factors. Common injuries to human skin mainly include burns, scalds, acute or chronic ulcers, and surgical wounds. After a large area of ​​skin is injured, it is easy to be infected by bacteria, loss of body fluids and various complications. In severe cases, it can lead to increased metabolism, decreased body temperature, excessive loss of water and protein, and disorders of the endocrine and immune systems, etc., and even endanger the skin. Life, these are all related to the loss of skin barrier function. Therefore, it is very necessary to create a good wound healing environment. With the proposal of the theory of wet wound healing, var...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/61A61K31/722A61P31/04A61P7/04A61P29/00
CPCA61K9/12A61K31/722A61K47/61A61P7/04A61P29/00A61P31/04
Inventor 郭瑞忠王亚佩王先明陈君德王国源施明华
Owner 宁波科瑞特动物药业有限公司
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