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A preparation method of pinoresinol diglucoside molecularly imprinted microspheres

A technology of pinoresinol diglucoside and molecularly imprinted microspheres, applied in chemical instruments and methods, other chemical processes, alkali metal compounds, etc. The effect of high product recovery rate

Inactive Publication Date: 2020-01-14
JISHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the use of metal-organic framework materials for chromatographic immobilization is a current research hotspot, but there are relatively few studies on the preparation of imprinted polymers using metal-organic framework materials as carriers.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) Preparation of carrier: Weigh chromium nitrate nonahydrate and terephthalic acid respectively at a molar ratio of 1:1.5, add them to 40mL deionized water, then add a small amount of hydrofluoric acid, stir and mix with ultrasonic waves, and pour the mixture into into the reaction kettle, sealed and reacted at 493K for 10-12 hours, cooled and filtered with a microporous membrane, washed with deionized water and N,N-dimethylformamide (DMF) respectively, and the The solid was added into ethanol and transferred to the reactor again, and reacted at a temperature of 373K for 18 hours. Cool to room temperature, filter and wash repeatedly with ethanol, vacuum dry, grind and sieve to obtain green solid powder. Put the green solid powder into a round-bottomed flask, add anhydrous toluene and stir evenly, treat with nitrogen for 5 minutes, add 5.0 mmol ethylenediamine, reflux for 10 hours, filter after cooling and wash the solid repeatedly with ethanol, dry and add Ground sup...

Embodiment 2

[0018] (1) Preparation of the carrier: Weigh chromium nitrate nonahydrate and terephthalic acid respectively at a molar ratio of 1:3.5, add them to 60mL of deionized water, add a small amount of hydrofluoric acid, stir and mix with ultrasonic waves, and pour the mixture into Put it into the reaction kettle, seal it and react at 493K for 12 hours, after cooling, filter it with a microporous membrane, wash the solid with deionized water and N,N-dimethylformamide (DMF), and add the solid to into ethanol and transferred to the reactor again, and reacted at a temperature of 373K for 20 hours. Cool to room temperature, filter and wash repeatedly with ethanol, vacuum dry, grind and sieve to obtain green solid powder. Put the green solid powder into a round-bottomed flask, add anhydrous toluene and stir evenly, treat with nitrogen for 5 minutes, add 6.0 mmol ethylenediamine, reflux for 10 hours, filter after cooling and wash the solid repeatedly with ethanol, dry and add Ground suppo...

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Abstract

The invention discloses a method for preparing pinoresinol diglucoside molecularly imprinted microspheres. The method comprises the following steps: (1) putting water and a small amount of hydrofluoric acid into chromic nitrate nonahydrate and terephthalic acid to carry out a reaction; cooling, filtering, adding anhydrous methylbenzene and ethidene diamine, and carrying out steps such as backflowing so as to obtain a carrier material; (2) weighing the carrier material, adding deionized water-DMSO (Dimethyl Sulfoxide) and azodiisobutyronitrile, and introducing helium so as to obtain a solutionA; dissolving pinoresinol diglucoside into a mixed solvent of methanol-isooctane-methylbenzene, and adding a surfactant and a dopamine-acrylamide mixture so as to obtain a solution B; mixing the solution A with the solution B, and carrying out precipitation polymerization reaction in an oil bath at 60 DEG C, thereby obtaining the pinoresinol diglucoside molecularly imprinted microspheres. By adopting the method, high specific surface properties of a metallic organic framework material are combined with high selectivity of a molecular imprinting material, the obtained imprinted microspheres have efficient separation capabilities for a target compound, and can be applied to extraction and purification of hypotensive active compounds in plants, and in addition, the imprinted microspheres canbe repeatedly used after being recycled, so that the production cost can be lowered.

Description

technical field [0001] The invention belongs to the field of new materials, in particular to a method for preparing novel imprinted microspheres with high selective adsorption capacity for pinoresinol diglucoside. Background technique [0002] Eucommia ulmoides is a precious Chinese medicinal material in my country, which has biological activities such as lowering blood pressure. Among them, pinoresinol diglucoside is a typical blood pressure lowering biomass. At the same time, this compound also has the functions of increasing cerebral blood flow, improving immunity, improving learning and memory, Anti-tumor, hypoglycemic, hangover and other effects are widely used in clinical applications. Isolation and extraction of pinoresinol diglucoside from Eucommia ulmoides plant is the main way to obtain this active compound. However, some existing extraction techniques often make the extraction process very complicated and the extraction cost remains high due to the insufficient se...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F20/56C08G83/00C08J9/26B01J20/26B01J20/28B01J20/30
CPCB01J20/268B01J20/28019C08F20/56C08G83/008C08J9/26C08J2201/0422
Inventor 李辉宋俊杰黄信慧张月
Owner JISHOU UNIVERSITY
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