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Flavonoid pharmaceutical composition, preparation and application

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of prolonging the recovery time of dermatitis, failing to meet clinical needs, increasing the incidence of dermatitis, etc., and preventing and reducing moderate and severe radiation dermatitis. , Good skin repair effect, the effect of strengthening the anti-radiation ability

Active Publication Date: 2021-01-19
吉林舒润药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hormone therapy can indeed inhibit the occurrence of skin inflammation in the early stage of radiotherapy, but as the radiotherapy cycle continues, hormones can cause skin thinning and skin fibrosis, which in turn leads to an increase in the incidence of moderate to severe dermatitis and prolongs the recovery time of dermatitis. Therefore, hormone therapy has limitations and cannot meet clinical needs

Method used

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  • Flavonoid pharmaceutical composition, preparation and application
  • Flavonoid pharmaceutical composition, preparation and application
  • Flavonoid pharmaceutical composition, preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1. Extraction and identification of total anthraquinone components from rhubarb, extraction and identification of flavonoid components from grape leaves, and preparation of comfrey oil.

[0047] 1. Preparation and determination of rhubarb extract

[0048] Take rhubarb coarse powder, add 10 times the amount of 75% ethanol and heat it under reflux for 1 hour to enrich the ethanol extract, add 5 times the amount of 75% ethanol to the residue and extract twice under reflux, each time for 30 minutes. The combined ethanol extracts were concentrated to an appropriate volume, neutralized by adding 1-2% sodium hydroxide and filtered, the filtrate was adjusted to a pH value of about 2 with dilute hydrochloric acid, filtered by suction, and the precipitate was dried to obtain a rhubarb extract.

[0049] Qualitative identification by thin-layer chromatography, thin-layer plate: silica gel G-CMC-Na; spotting: ethanol solution of total anthraquinone sample, ethanol solution o...

Embodiment 2

[0063] Embodiment 2. Gel components and preparation process of different prescriptions.

[0064] In the early exploration process, the present invention began to explore the individual effects of flavonoid monomer compounds with higher purity such as quercetin, naringenin and genistein, and irradiated mice with large doses of gamma rays such as 20Gy For the chest, the effect of the flavonoids was observed about a week after irradiation, and it was found that the effect of quercetin and genistein at the same dose was better than that of naringenin. In the course of the experiment, it was found creatively that the combined application of the three flavonoids has a far better effect than the respective effects of the flavonoids.

[0065] Moreover, the present invention has found through further research that: when the flavonoid composition is used in conjunction with some plant extracts, such as rhubarb extract and comfrey extract, the skin redness, swelling or even rupture cause...

Embodiment 3

[0102] Example 3 Anti-inflammatory effects of different formula gel groups and 0.9% normal saline group in acute radiation dermatitis in mice after single irradiation.

[0103] In the experiment, 100 Balb / C mice were selected, 20 in each group, and randomly divided into five groups, namely groups 1, 2, and 3 with different gel formulations, normal saline group, and blank control group. Wherein, normal saline was used as a positive control group, and the normal saline used was 0.9% normal saline, and the blank control group was not treated.

[0104] Experimental irradiation site: mouse chest.

[0105] Experimental method: After shaving the chest of the mice, apply different preparations in each group 2 days before irradiation, and the mice were anesthetized with 6 mg / mL pentobarbital sodium intraperitoneally for 5-10 minutes (100 μL / 10 g) to protect the mice. fixed, then use 60 Co, the average dose rate of gamma rays is about 1.8Gy / min, and the total irradiation time is 8 min...

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Abstract

A flavonoid pharmaceutical composition, a preparation and application. The invention relates to the field of pharmaceutical compositions and particularly relates to a pharmaceutical composition for preventing and treating radioactive dermatitis and skin injury, a preparation of the pharmaceutical composition and application of the pharmaceutical composition. The pharmaceutical composition is prepared from naringenin, quercetin and genistein. The preparation is prepared from the pharmaceutical composition. The pharmaceutical composition can be used for preparing drugs for preventing and treating radiodermatitis. The pharmaceutical composition provided by the invention can be applied to the therapy and remediation of the radiodermatitis, particularly the prevention and alleviation of mediumand severe radiodermatitis and has a good application value.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical composition for preventing and treating radiation-induced dermatitis and skin damage, as well as its preparation and application. Background technique [0002] Among all malignant tumor patients, about 60-70% of patients will receive radiation therapy during their treatment, and many early tumors can be cured by radiation therapy, such as: early tongue cancer, nasopharynx, laryngeal cancer, esophagus cancer The cure rate of radiotherapy and chemotherapy for cancer and cervical cancer is about 90%. [0003] Radiation therapy kills cancer cells, and at the same time causes penetrating damage to the skin from the outside to the inside, and damages the superficial skin and internal tissues. From the perspective of pathogenic mechanism, the early sustained immune response after radiotherapy can cause chronic inflammation, and DNA fragments and reactive oxyg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/87A61K31/352A61P17/00A61P17/16
CPCA61K31/352A61K36/30A61K36/708A61K36/87A61K2236/333A61P17/00A61P17/16A61K2300/00
Inventor 李智民
Owner 吉林舒润药业有限公司
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