A kind of amine oxide type quaternized chitosan iodine and its preparation method and application

A technology of chitosan iodine and amine oxide, which is applied in the chemical field, can solve the problems of chitosan iodine sterilization, and the healing effect cannot reach the expected effect, and achieve the effect of degradable wound protection, wound protection and adhesion prevention

Active Publication Date: 2021-06-15
SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is severely restricted by the solubilizing and stabilizing effect of surfactants, and completely loses the original intention of developing chitosan quaternary ammonium salt iodine, and the bactericidal and healing effects of the prepared chitosan iodine are far from expected.

Method used

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  • A kind of amine oxide type quaternized chitosan iodine and its preparation method and application
  • A kind of amine oxide type quaternized chitosan iodine and its preparation method and application
  • A kind of amine oxide type quaternized chitosan iodine and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] (1), preparation of quaternization reagent

[0062] Add 20g of diethyl secondary amine into 100ml of ethanol, turn on the stirring and heating device, stir evenly, control the reaction temperature at 25°C, then add 25.5g of epichlorohydrin dropwise, and control the dropping time for 30min. After the dropping is completed, The reaction was continued for 8 hours. Subsequently, the temperature was raised to 35° C., and 40.2 g of sodium hydroxide solution with a mass concentration of 30% was added dropwise, and the dropping time was controlled to be 3 hours. After the dropwise addition, the reaction was continued for 3 hours, and then the precipitated components during the reaction were filtered out, the solvent was distilled off under reduced pressure, and vacuum-dried at 40° C. to obtain the quaternization reagent.

[0063] (2), prepare quaternized chitosan

[0064] Dissolve 5g of chitosan in 100g of acetic acid solution with a mass concentration of 1%, turn on the stir...

Embodiment 2

[0069] (1), preparation of quaternization reagent

[0070] Add 20g of dipentyl secondary amine to 50ml of ethanol, turn on the stirring and heating device, stir evenly, control the reaction temperature at 30°C, then add 25.5g of epoxychlorobutane dropwise, and control the dropping time to 40min. , continue to react for 7 hours. Subsequently, the temperature was raised to 35° C., and 40.2 g of a sodium hydroxide solution with a mass concentration of 30% was added dropwise, and the dropping time was controlled to be 2 hours. After the dropwise addition was completed, the reaction was continued for 4 hours, and then the precipitated components during the reaction were filtered out, the solvent was distilled off under reduced pressure, and vacuum-dried at 40° C. to obtain the quaternization reagent.

[0071] (2), prepare quaternized chitosan

[0072] Dissolve 10g of chitosan in 100g of citric acid solution with a mass concentration of 2%, turn on the stirring and heating device,...

Embodiment 3

[0077] (1), preparation of quaternization reagent

[0078] Add 20g of diethanol secondary amine into 33.3ml of isopropanol, turn on the stirring and heating device, stir evenly, control the reaction temperature to 35°C, then add 25.5g of epichloropentane dropwise, control the dropping time to 60min, add dropwise After completion, the reaction was continued for 6 hours. Subsequently, the temperature was raised to 40° C., and 40.2 g of sodium hydroxide solution with a mass concentration of 30% was added dropwise, and the dropping time was controlled to be 4 hours. After the dropwise addition was completed, the reaction was continued for 5 hours, and then the precipitated components during the reaction were filtered out, the solvent was distilled off under reduced pressure, and vacuum-dried at 50° C. to obtain a quaternization reagent.

[0079] (2), prepare quaternized chitosan

[0080] Dissolve 15g of chitosan in 100g of oxalic acid solution with a mass concentration of 3%, tu...

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Abstract

The invention provides an amine oxide-type quaternized chitosan iodine, which is prepared from the following raw materials in mass percentage: amine oxide-type quaternized chitosan 85-95%; iodine 5-15%; the amine oxide The type quaternized chitosan is obtained by oxidizing the quaternized chitosan with a peroxide; the peroxide is hydrogen peroxide or an organic peroxide. It also provides the preparation method and application of the above-mentioned amine oxide type quaternized chitosan iodine. The amine oxide type quaternized chitosan iodine of the present invention has good complexation effect with iodine, high content of available iodine and good stability. The two synergistically improve the antibacterial and antiviral effects, and have high-efficiency and broad-spectrum bactericidal effects. The slow release of iodine reduces the stimulating effect of elemental iodine. Good biocompatibility, degradability, and wound protection, hemostasis, antibacterial, healing promotion and adhesion prevention effects on wounds, providing a new treatment method for the treatment of wounds.

Description

technical field [0001] The invention belongs to the field of chemistry, and in particular relates to an amine oxide-type quaternized chitosan iodine and its preparation method and application. Background technique [0002] Chitin is a six-carbon polymer similar to plant fibers. It is the only cationic biodegradable polymer material in nature. It is widely found in crustaceans such as shrimps and crabs, as well as insects, algae and bacteria. Among them, it is also called animal element, chitin, chitin or chitin. The annual biosynthesis of chitin in nature is nearly 10 billion tons, which is another important polysaccharide besides cellulose. [0003] Before the 1970s, the research on chitin and chitosan was mainly concentrated in European and American countries. Since the 1980s, there has been an upsurge of research on chitin and chitosan worldwide. Chitin and chitosan have been called the sixth vital elements by modern science after the five vital elements of protein, su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A61K31/722A61P17/02A61P31/02A61P7/04
CPCA61K31/722A61P7/04A61P17/02A61P31/02C08B37/003
Inventor 王宇朱广东陈占
Owner SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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