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A kind of preparation method of epoxy and aminophosphorylcholine polymer biomimetic adhesion coating

A technology of aminophosphorylcholine and phosphorylcholine, which is applied in the direction of coating, can solve the problems of the stability to be improved, and the adhesion of the imitation mussel adhesion coating is not strong, and achieves convenient operation and a preparation method The effect of simplicity and broad application prospects

Inactive Publication Date: 2021-07-27
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This biomimetic adhesion method can increase the stability of the coating to a certain extent, but the adhesion of the imitation mussel adhesion coating is not strong, and the stability needs to be improved

Method used

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  • A kind of preparation method of epoxy and aminophosphorylcholine polymer biomimetic adhesion coating
  • A kind of preparation method of epoxy and aminophosphorylcholine polymer biomimetic adhesion coating

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preparation example Construction

[0025] A kind of preparation method of epoxy and aminophosphorylcholine polymer biomimetic adhesion coating of the present invention, comprises the following steps:

[0026]Step 1, under the protection of nitrogen, the vinyl monomer (glycidyl methacrylate) containing epoxy and the vinyl monomer (methacryloyloxyethylphosphorus) containing phosphorylcholine hydrophilic group acylcholine) under the action of initiator to carry out free radical solution polymerization to synthesize phosphorylcholine polymer containing epoxy; vinyl monomer containing phosphorylcholine hydrophilic group and vinyl monomer containing epoxy The molar ratio of the base monomer is (9.5:0.5)~(5:5); the molar ratio of the vinyl monomer containing phosphorylcholine hydrophilic group to the vinyl monomer containing amino group is (9.5:0.5 )~(5:5). The solvent is a mixed solvent of methanol and tetrahydrofuran (volume ratio 4:1), the initiator is azobisisobutyronitrile, the reaction temperature is 65-80°C, t...

Embodiment 1

[0032] Weigh 12mmol 2-methacryloyloxyethylphosphorylcholine and 8mmol glycidyl methacrylate, use 0.1mmol azobisisobutyronitrile as the initiator, and methanol and tetrahydrofuran with a volume ratio of 4:1 as the solvent , under the protection of nitrogen, polymerize at 70°C for 24h. After the reaction, concentrate the reaction solution, dialyze with a dialysis bag with a molecular weight cut-off of 6000-8000D, and then freeze-dry at -50°C to obtain phosphorylcholine containing epoxy polymer.

[0033] Weigh 15mmol 2-methacryloyloxyethyl phosphorylcholine and 5mmol 2-aminoethyl methacrylate hydrochloride, use 0.1mmol potassium persulfate as initiator, distilled water as solvent, under nitrogen protection, Polymerization at 70°C for 12 hours, dialyzed after the reaction, and then freeze-dried at -50°C to obtain phosphorylcholine polymers containing amino groups.

[0034] The epoxy-containing phosphorylcholine polymer and amino group-containing phosphorylcholine polymer prepared...

Embodiment 2

[0039] Weigh 19mmol 2-methacryloyloxyethylphosphorylcholine and 1mmol glycidyl methacrylate, use 0.1mmol azobisisobutyronitrile as the initiator, and methanol and tetrahydrofuran with a volume ratio of 4:1 as the solvent , under the protection of nitrogen, polymerize at 70°C for 24h. After the reaction, concentrate the reaction solution, dialyze with a dialysis bag with a molecular weight cut-off of 6000-8000D, and then freeze-dry at -50°C to obtain phosphorylcholine containing epoxy polymer.

[0040] Weigh 10mmol 2-methacryloyloxyethyl phosphorylcholine and 10mmol 2-aminoethyl methacrylate hydrochloride, use 0.1mmol potassium persulfate as initiator, distilled water as solvent, under nitrogen protection, Polymerization at 70°C for 12 hours, dialyzed after the reaction, and then freeze-dried at -50°C to obtain phosphorylcholine polymers containing amino groups.

[0041] The epoxy-containing phosphorylcholine polymer and amino group-containing phosphorylcholine polymer prepare...

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Abstract

The invention relates to a preparation method of epoxy and aminophosphorylcholine polymer biomimetic adhesion coating. The vinyl monomer containing phosphorylcholine hydrophilic group and the vinyl monomer containing epoxy are polymerized by simple solution free radicals to synthesize the phosphorylcholine polymer containing epoxy. The vinyl monomer containing the phosphorylcholine hydrophilic group and the vinyl monomer containing the amino group are free radically polymerized to synthesize the phosphorylcholine polymer containing the amino group. Two kinds of phosphorylcholine polymers and dopamine are dissolved in a polar solvent, coated on the surface of chitosan membrane, dried and placed in Tris-HCl solution for heat treatment to prepare a membrane structure imitating the outer layer of cells. Bionic adhesion coating. This method is simple to prepare and easy to operate, and provides a new way to obtain biomimetic adhesive coatings with excellent blood compatibility.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and in particular relates to a preparation method of an epoxy and aminophosphorylcholine polymer bionic adhesion coating. Background technique [0002] Chitosan has the advantages of degradability, antibacterial, non-toxic, non-irritating, and pH responsiveness (Carbohydrate Polymers 2010, 79:724-730), and has been widely used in biomedicine and other fields. More and more studies have shown that chitosan and its derivatives can be used for blood purification. The amino group on the chitosan molecule helps to adsorb various toxins in the blood, and can be used as a hemoperfusion material (Chemical Journal of Chinese Universities, 2002, 23:75-77; Journal of Microencapsulation 1993, 10:475-486). Chitosan membrane has high dialysis rate, selectivity and strength, and can be used as hemodialysis material (Journal of Applied Polymer Science 1992, 46:...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/056C09D143/02C08F230/02C08F220/32C08F220/34C08L5/08
CPCC09D143/02C08F220/32C08F220/34C08F230/02C08J2305/08C08J7/0427C08F220/325
Inventor 宫铭
Owner XIAN UNIV OF SCI & TECH