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Method for producing composite PGA/DMBG bone stent from polydopamine modified mesoporous bioglass

A polydopamine and bioglass technology, used in tissue regeneration, medical science, prosthesis, etc., can solve the problems of far-flung interfacial properties, uneven dispersion of MBG, and difficulty in interfacial bonding, and achieve good biological activity and mechanical properties. , the effect of promoting biological bonding and improving biological performance

Inactive Publication Date: 2018-11-06
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PGA and MBG belong to organic phase and inorganic phase respectively, and their interfacial properties are very different, it is difficult to form strong interfacial bonding, and it is prone to uneven dispersion and agglomeration of MBG in the PGA matrix.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Weigh 2 g of dopamine hydrochloride powder with an electronic balance, and add it into 10 mM Tris-HCl buffer solution to prepare a 2 mg / ml dopamine solution (pH=8.5).

[0028] 2) Use an electronic balance to weigh 5g MBG, add it to the dopamine solution prepared above, and mix evenly by magnetic stirring. The main process parameters are: the reaction time is 5h, and the magnetic stirring speed is 300r / min; after that, the resulting suspension is filtered and separated. and then washed repeatedly with deionized water; after drying overnight in a vacuum oven at 60°C, polydopamine-modified DMBG particles were obtained.

[0029] 3) Use an electronic balance to weigh 9 g of PGA powder with a particle size of 40 μm and a melting point of 220 ° C, and 1 g of DMBG prepared in step 2, and then add them to a beaker filled with 50 ml of absolute ethanol. The two solutions are subjected to magnetic stirring and ultrasonic dispersion technology respectively. Mix evenly, the main ...

Embodiment 2

[0034] 1) Weigh 2 g of dopamine hydrochloride powder with an electronic balance, and add it into 10 mM Tris-HCl buffer solution to prepare a 2 mg / ml dopamine solution (pH=8.5).

[0035]2) Use an electronic balance to weigh 5g MBG, add it to the dopamine solution prepared above, and mix evenly by magnetic stirring. The main process parameters are: the reaction time is 5h, and the magnetic stirring speed is 300r / min; after that, the resulting suspension is filtered and separated. and then washed repeatedly with deionized water; after drying overnight in a vacuum oven at 60°C, polydopamine-modified DMBG particles were obtained.

[0036] 3) Use an electronic balance to weigh 8.5 g of PGA powder with a particle size of 40 μm and a melting point of 220 ° C, and 1.5 g of DMBG prepared in step 2, and then add them to a beaker containing 50 ml of absolute ethanol. The two solutions are magnetically stirred and Ultrasonic dispersion technology mixes evenly, the main process parameters a...

Embodiment 3

[0041] 1) Weigh 2 g of dopamine hydrochloride powder with an electronic balance, and add it into 10 mM Tris-HCl buffer solution to prepare a 2 mg / ml dopamine solution (pH=8.5).

[0042] 2) Use an electronic balance to weigh 5g MBG, add it to the dopamine solution prepared above, and mix evenly by magnetic stirring. The main process parameters are: the reaction time is 5h, and the magnetic stirring speed is 300r / min; after that, the resulting suspension is filtered and separated. and then washed repeatedly with deionized water; after drying overnight in a vacuum oven at 60°C, polydopamine-modified DMBG particles were obtained.

[0043] 3) Use an electronic balance to weigh 9.5 g of PGA powder with a particle size of 40 μm and a melting point of 220 ° C, and 0.5 g of DMBG prepared in step 2, and then add them to a beaker containing 50 ml of absolute ethanol. The two solutions are magnetically stirred and Ultrasonic dispersion technology mixes evenly, the main process parameters ...

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Abstract

The invention discloses a method for producing a composite PGA / DMBG bone stent from polydopamine modified mesoporous bioglass. The method comprises the following steps: modifying polydopamine by usingan in-situ polymerization method on the surface of an MBG powder to obtain a DMBG powder; mixing the DMBG powder and a PGA powder by a liquid phase, performing solid-liquid separation to obtain a solid, drying and grinding the solid to obtain a composite PGA / DMBG powder; and performing selective laser sintering on the obtained composite PGA / DMBG powder to obtain a composite PGA / DMBG bone stent. The composite stent has the good Biological activity, cell response and enhanced mechanical properties and has a broad application prospect in the tissue engineering field.

Description

technical field [0001] The invention relates to a composite bone support, in particular to a method for improving the performance of a polyglycolic acid bone support by modifying mesoporous bioglass with polydopamine, and belongs to the technical field of artificial bone support materials. Background technique [0002] Polyglycolic acid (PGA) is considered as a promising bone scaffold material due to its good biocompatibility and biodegradability. However, due to the lack of biological activity and acidic degradation products, its wider application in the field of bone tissue engineering is limited. Mesoporous bioglass has a large number of silanol groups, which can promote the nucleation and growth of bone-like apatite through condensation reaction and ion adsorption, and has good biological activity. In addition, during the degradation process of mesoporous bioglass (MBG), it can not only release active elements such as silicon calcium to promote the transformation of col...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/18A61L27/50A61L27/54
CPCA61L27/10A61L27/18A61L27/50A61L27/54A61L2300/10A61L2300/412A61L2430/02C08L79/02C08L67/04
Inventor 帅词俊冯佩
Owner CENT SOUTH UNIV
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