Method for producing composite PGA/DMBG bone stent from polydopamine modified mesoporous bioglass
A polydopamine and bioglass technology, used in tissue regeneration, medical science, prosthesis, etc., can solve the problems of far-flung interfacial properties, uneven dispersion of MBG, and difficulty in interfacial bonding, and achieve good biological activity and mechanical properties. , the effect of promoting biological bonding and improving biological performance
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[0026] Example 1
[0027] 1) Use an electronic balance to weigh 2 g of dopamine hydrochloride powder and add it to 10 mM Tris-HCl buffer to prepare a 2 mg / ml dopamine solution (pH=8.5).
[0028] 2) Use an electronic balance to weigh 5g of MBG, add it to the dopamine solution prepared above, and mix it evenly with magnetic stirring. The main process parameters are: reaction time 5h, magnetic stirring speed 300r / min; after that, the resulting suspension is filtered and separated out And then repeatedly washed with deionized water; dried overnight in a vacuum oven at 60°C to obtain polydopamine-modified DMBG particles.
[0029] 3) Use an electronic balance to weigh 9g of PGA powder with a particle size of 40μm and a melting point of 220°C, and 1g of DMBG prepared in step 2, and add them to a beaker containing 50ml of absolute ethanol. The two solutions are respectively subjected to magnetic stirring and ultrasonic dispersion techniques The mixing is uniform, the main process parameters...
Example Embodiment
[0033] Example 2
[0034] 1) Use an electronic balance to weigh 2 g of dopamine hydrochloride powder and add it to 10 mM Tris-HCl buffer to prepare a 2 mg / ml dopamine solution (pH=8.5).
[0035] 2) Use an electronic balance to weigh 5g of MBG, add it to the dopamine solution prepared above, and mix it evenly with magnetic stirring. The main process parameters are: reaction time 5h, magnetic stirring speed 300r / min; after that, the resulting suspension is filtered and separated out And then repeatedly washed with deionized water; dried overnight in a vacuum oven at 60°C to obtain polydopamine-modified DMBG particles.
[0036] 3) Use an electronic balance to weigh 8.5g of PGA powder with a particle size of 40μm and a melting point of 220°C and 1.5g of DMBG prepared in step 2, and then add them to a beaker containing 50ml of absolute ethanol. The two solutions are magnetically stirred and The ultrasonic dispersion technology mixes uniformly. The main process parameters are: magnetic st...
Example Embodiment
[0040] Example 3
[0041] 1) Use an electronic balance to weigh 2 g of dopamine hydrochloride powder and add it to 10 mM Tris-HCl buffer to prepare a 2 mg / ml dopamine solution (pH=8.5).
[0042] 2) Use an electronic balance to weigh 5g of MBG, add it to the dopamine solution prepared above, and mix it evenly with magnetic stirring. The main process parameters are: reaction time 5h, magnetic stirring speed 300r / min; after that, the resulting suspension is filtered and separated out And then repeatedly washed with deionized water; dried overnight in a vacuum oven at 60°C to obtain polydopamine-modified DMBG particles.
[0043] 3) Use an electronic balance to weigh 9.5 g of PGA powder with a particle size of 40 μm and a melting point of 220 ℃, and 0.5 g of DMBG prepared in step 2, and then add them to a beaker containing 50 ml of absolute ethanol. The two solutions are magnetically stirred and The ultrasonic dispersion technology mixes uniformly. The main process parameters are: magnet...
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