A chiral nitrogen nitrogen phosphine tridentate ligand based on a ferrocene skeleton and an application thereof

Abstract

The invention belongs to the technical field of asymmetric catalysis and specifically relates to a chiral nitrogen nitrogen phosphine tridentate ligand based on a ferrocene skeleton and an applicationthereof. A coordination compound is obtained by the disclosed chiral nitrogen nitrogen phosphine tridentate ligand base on the ferrocene skeleton complexed with a transition metal precursor, the complex is used as a precious metal catalyst, and is successfully applied to high efficiency asymmetric hydrogenation of aromatic ketone. Compared with other tridentate ligands, the ligand is simple to synthetize, is stable to water and air, and easy to prepare on a large scale, shows high activity and high enantioselectivity on carbon and oxygen double bond, and has greater implementation value and social and economic benefits.

Description

technical field

[0001] The invention belongs to the technical field of asymmetric catalysis, and in particular relates to a chiral tridentate ligand based on a ferrocene skeleton and an application thereof. Background technique

[0002] Chirality is one of the essential attributes of nature, and the use of chiral drugs and chiral pesticides can often achieve better therapeutic or insecticidal effects. Asymmetric catalytic hydrogenation, as one of the important methods to obtain chiral compounds, has the advantages of good atom economy and high stereoselectivity, and has always been one of the research hotspots.

[0003] The combination of metal and chiral ligand has become the mainstream of asymmetric catalytic hydrogenation due to its excellent catalytic performance. As early as the 1970s, William S. Knowles used metal rhodium and organophosphine ligands to realize asymmetric catalytic hydrogenation for the first time, and applied it to the industrial synthesis of chiral d...

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