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Multi-vitamin mineral soft capsule being rich in alpha-linolenic acid and preparation method thereof

A technology of vitamins and linolenic acid, applied in food science, functions and applications of food ingredients, etc., can solve the problems of limiting research and development of soft capsules, lack of α-linolenic acid supplementation, and complicated research on influencing factors, and achieve scientific formula design , stable product quality and simple preparation method

Pending Publication Date: 2018-11-23
德瑞美医药生物技术盐城有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing nutrient preparations on the market are tablets that simply supplement vitamins and minerals. Multivitamin and mineral tablets contain fat-soluble vitamins A, D, E, K and water-soluble vitamin B complex and other vitamins and minerals. , can help the human body to supplement a variety of vitamins and minerals. However, the human body can only supplement a variety of vitamins and minerals when taking this preparation. On the other hand, in order to ensure the compressibility, aesthetics and certain physical indicators of the tablet, about 20-50% of auxiliary materials are added during the formulation design process, including disintegrants, lubricants, fillers, colorants, Anti-caking agents, etc., long-term use of some excipients will have certain side effects on the human body, so it is of great significance to design a capsule preparation that can supplement multiple vitamins, minerals and α-linolenic acid at the same time
[0004] However, since the multivitamin and mineral preparations containing α-linolenic acid contain many nutrients, the research on the influencing factors between the components is complicated. If the minerals and α-linolenic acid contained in the preparation are not properly handled during production It will also lead to relatively serious delamination and leakage, which limits the further research and development of soft capsules in the field of such preparations. There are no related reports on multivitamin and mineral preparation soft capsules containing α-linolenic acid.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A multi-vitamin mineral soft capsule rich in α-linolenic acid and a preparation method thereof, the soft capsule includes contents and a capsule shell coated outside the contents, and the contents include The following raw materials: 28 parts of calcium carbonate, 16 parts of magnesium carbonate, 6 parts of ferrous gluconate, 1.6 parts of zinc gluconate, 0.05 parts of retinyl palmitate, 0.025 parts of vitamin D3, 1 part of d-α-tocopherol, compounded 3 parts of nutrient enhancer premix, 3 parts of linolenic acid, 3 parts of beeswax, 26 parts of walnut oil, 26 parts of linseed oil; the formula of the compound nutrient enhancer premix is: every 1000 parts of premix Contains 13 parts of thiamine hydrochloride, 13 parts of riboflavin, 13 parts of pyridoxine hydrochloride, 2.67 parts of cobalamin, 75 parts of nicotinamide, 748.33 parts of L-ascorbic acid, 23.33 parts of folic acid, 49.67 parts of D-calcium pantothenate, The balance is starch; the capsule shell includes the fo...

Embodiment 2

[0026] A multi-vitamin mineral soft capsule rich in α-linolenic acid and a preparation method thereof, the soft capsule includes contents and a capsule shell coated outside the contents, and the contents include The following raw materials: 20 parts of calcium carbonate, 10 parts of magnesium carbonate, 1 part of ferrous gluconate, 0.5 part of zinc gluconate, 0.02 part of retinyl palmitate, 0.01 part of vitamin D3, 0.3 part of d-α-tocopherol, compounded 2 parts of nutrient enhancer premix, 1 part of linoleic acid, 1 part of beeswax, 10 parts of walnut oil, 15 parts of linseed oil; the formula of the compound nutrient enhancer premix is: every 1000 parts premix The material contains 10 parts of thiamine hydrochloride, 10 parts of riboflavin, 10 parts of pyridoxine hydrochloride, 1.35 parts of cobalamin, 68 parts of nicotinamide, 742.58 parts of L-ascorbic acid, 22 parts of folic acid, and 47.25 parts of D-calcium pantothenate , the balance is starch; the capsule shell includes ...

Embodiment 3

[0029]A multi-vitamin mineral soft capsule rich in α-linolenic acid and a preparation method thereof, the soft capsule includes contents and a capsule shell coated outside the contents, and the contents include The following raw materials: 35 parts of calcium carbonate, 25 parts of magnesium carbonate, 8 parts of ferrous gluconate, 3 parts of zinc gluconate, 0.1 part of retinyl palmitate, 0.05 parts of vitamin D3, 2 parts of d-α-tocopherol, compounded 5 parts of nutrient fortifier premix, 5 parts of lauric acid, 4 parts of beeswax, 45 parts of walnut oil, 45 parts of linseed oil; the formula of the compound nutrient fortifier premix is: every 1000 parts of premix Contains 15 parts of thiamine hydrochloride, 15 parts of riboflavin, 15 parts of pyridoxine hydrochloride, 4.67 parts of cobalamin, 80 parts of nicotinamide, 753 parts of L-ascorbic acid, 25.5 parts of folic acid, 53.72 parts of D-calcium pantothenate, The balance is starch; the capsule shell includes the following ra...

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PUM

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Abstract

The invention belongs to the technical field of processing of soft capsules. A majority of existing nutrient preparations are tables which purely supplement vitamin minerals, and therefore, the existing nutrient preparations are not suitable for meeting the needs of special populations like pregnant women. Based on the problems in the prior art, the invention discloses the multi-vitamin mineral soft capsule being rich in alpha-linolenic acid and the preparation method thereof. The preparation method comprises the following steps: firstly, by using beewax and single-and-bis-glycerol aliphatic acid ester as auxiliaries, an alpha-linolenic acid rich mixture of linseed oil and walnut oil is uniformly mixed with a mixture of the multi-vitamin minerals so as to obtain a stable inclusion; then preparing a gelatin solution; finally, compressing the prepared gelatin solution and the inclusion on a soft capsule compressing machine into gelatin pills so as to obtain the soft capsule. The formulaof the soft capsule has scientific design, and covers the necessary multi-vitamin minerals and alpha-linolenic acid required by a human body, and the soft capsule is easy to store and carry; therefore, the multi-vitamin mineral soft capsule is particularly applied to intake of nutrition for kids and teenagers, middle-aged and elderly people, pregnant women and the like.

Description

technical field [0001] The invention relates to a soft capsule and a preparation method thereof, in particular to a multi-vitamin and mineral soft capsule rich in α-linolenic acid and a preparation method thereof, belonging to the technical field of soft capsule processing. Background technique [0002] α-linolenic acid is a polyunsaturated fatty acid, which is the core substance of life. It is an essential fatty acid that maintains human evolution and maintains good health. The human body cannot synthesize it by itself, and can only be taken from food to meet the body's needs. α-linolenic acid in the human liver, under the action of desaturases and elongases, can be converted into essential life active factors for the human body - EPA (eicosapentaenoic acid, commonly known as vascular scavenger) and DHA (20 Dicosahexaenoic acid, commonly known as brain gold). After more than 50 years of research on α-linolenic acid by scientists around the world, it has been found that α-l...

Claims

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Application Information

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IPC IPC(8): A23L33/00A23L33/115A23L33/15A23L33/16
CPCA23V2002/00A23L33/00A23L33/115A23L33/15A23L33/16A23V2200/30
Inventor 陈浩
Owner 德瑞美医药生物技术盐城有限公司