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Composition containing probiotics metabolite

A technology of metabolites and probiotics, applied in drug combinations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve problems such as high environmental requirements, troublesome clinical medication, and reduced number of viable bacteria, so as to reduce waste Discharge, avoid colonization failure, quality stable effect

Inactive Publication Date: 2018-11-27
FUJIAN AONONG BIOLOGICAL TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the live bacteria preparation has certain defects in storage and use. The storage process has high environmental requirements, and temperature, moisture, etc. may cause the number of live bacteria to decrease, resulting in a decline in curative effect. The components of antibiotics kill or reduce the effectiveness and cannot be mixed with other drugs with antibacterial activity, which will cause troubles for clinical medication and increase costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A composition containing metabolites of probiotics, mainly composed of metabolites of probiotics in pig intestines, oligosaccharides and egg yolk antibodies.

[0036] The probiotic metabolites are lactobacillus metabolites, bifidobacteria metabolites, and enterococcus metabolites. Mix the waste liquid from three types of probiotic fermentation liquid after recovering viable bacteria in equal volumes 1:1:1, filter and sterilize through a polypropylene microporous filter with a pore size of 0.2 μm, and then pass the filtrate through polyethersulfone with a molecular weight cut-off of 10KD Ultrafiltration with a central control fiber filter, desalination, dehydration, concentration to 1 / 10 of the original volume, and standby.

[0037] The oligosaccharide is an oligosaccharide mixture formed by mixing isomaltooligosaccharides, fructooligosaccharides, sucrose oligosaccharides and galactooligosaccharides in a mass ratio of 1:1:1:1.

[0038] The yolk antibody is anti-porcine ...

Embodiment 2

[0041] A composition containing metabolites of probiotics, mainly composed of metabolites of probiotics in pig intestines, oligosaccharides and egg yolk antibodies.

[0042] The probiotic metabolites are lactobacillus metabolites, bifidobacterium metabolites, Bacillus subtilis metabolites, and Bacillus licheniformis metabolites. Mix the waste liquid from four kinds of probiotic fermentation broths after recovering live bacteria according to equal volumes of 1:1:1:1, filter and sterilize through a polypropylene microporous filter with a pore size of 0.2 μm, and then pass the filtrate through a polypropylene filter with a molecular weight cut-off of 10KD. Ethersulfone central control fiber filter ultrafiltration, desalination, dehydration, concentrated to 1 / 10 of the original volume, for later use.

[0043] The oligosaccharide is an oligosaccharide mixture formed by mixing isomaltooligosaccharides, fructooligosaccharides, sucrose oligosaccharides and galactooligosaccharides in a...

Embodiment 3

[0047] A composition containing metabolites of probiotics, mainly composed of metabolites of probiotics in pig intestines, oligosaccharides and egg yolk antibodies.

[0048] The probiotic metabolites are lactobacillus metabolites, bifidobacterium metabolites, Bacillus subtilis metabolites, and yeast metabolites. Mix the waste liquid from four kinds of probiotic fermentation broths after recovering live bacteria according to equal volumes of 2:2:1:1, filter and sterilize through a polypropylene microporous filter with a pore size of 0.2 μm, and then pass the filtrate through a polypropylene filter with a molecular weight cut-off of 10KD. Ethersulfone central control fiber filter ultrafiltration, desalination, dehydration, concentrated to 1 / 20 of the original volume, for later use.

[0049] The oligosaccharide is an oligosaccharide mixture formed by mixing fructo-oligosaccharide and galacto-oligosaccharide at a mass ratio of 1:1.

[0050] The yolk antibody is anti-porcine trans...

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PUM

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Abstract

The invention relates to a composition containing probiotics metabolite. The composition is prepared from, by weight, 1-10 parts of probiotics metabolite, 2-3 parts of oligosaccharide and 3-8 parts ofpowder or liquid containing egg yolk antibody. Compared with the prior art, the composition containing the probiotics metabolite has the advantages that the waste discharge can be reduced, the wasteis turned into treasure, the bacteria reproduction can be selectively inhibited, and the composition is used for preventing or curing gastrointestinal infection caused by escherichia coli of piglets,salmonella, clostridium perfringens, porcine transmissible gastroenteritis virus, porcine epidemic diarrhea virus, porcine rotavirus and the like.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a composition containing metabolites of probiotics. Background technique [0002] Piglet gastrointestinal infection is a type of disease that seriously threatens the health and survival rate of piglets. Although gastrointestinal infection is easier to treat than other diseases, it is because of the widespread existence of pathogenic bacteria, and the immune system of newborn suckling piglets is not perfect, and the resistance is low , so the incidence is common, according to incomplete statistics, the incidence of piglets can be as high as 80%. [0003] The main pathogens of bacterial gastrointestinal infections are Escherichia coli, Salmonella, etc. There are many antibacterial drugs on the market for the treatment of such diseases, and the effect is very satisfactory, but drug resistance is prone to appear after repeated use. At the same time, there is also a kind of l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/42A61K9/14A61K47/46A61P31/04A61P31/12A61P1/00A61K31/7016A61K31/702A61K31/715A61K35/742A61K35/744A61K35/745A61K35/747A61K36/064
CPCA61K9/148A61K31/7016A61K31/702A61K31/715A61K35/742A61K35/744A61K35/745A61K35/747A61K36/064A61K39/42A61K47/46A61P1/00A61P31/04A61P31/12A61K2300/00
Inventor 王庆福黄静戴多亮梁世仁吴有林
Owner FUJIAN AONONG BIOLOGICAL TECH GRP CO LTD
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