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Degradable curcumin derivative-polylactic acid-polyglycolic acid composite film, and preparation method thereof

A technology of curcumin derivatives and polyglycolic acid, which is applied in the direction of drug combination, medical preparations of non-active ingredients, drug delivery, etc., can solve the problem of curcumin derivatives-polylactic acid-polyglycolic acid copolymer composite film that has not yet been involved Preparation methods and other issues to achieve excellent two-photon fluorescence performance, good imaging of biological cells, and enhanced optical properties

Inactive Publication Date: 2018-11-30
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] According to the existing polylactic acid-polyglycolic acid copolymer research, the research on curcumin derivative-polylactic acid-polyglycolic acid copolymer composite film and its preparation method has not yet been involved.

Method used

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  • Degradable curcumin derivative-polylactic acid-polyglycolic acid composite film, and preparation method thereof
  • Degradable curcumin derivative-polylactic acid-polyglycolic acid composite film, and preparation method thereof
  • Degradable curcumin derivative-polylactic acid-polyglycolic acid composite film, and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] (1) 2 grams of polylactic acid and 3 grams of polyglycolic acid are completely dissolved in 50 mL of chloroform;

[0033] (2) Heat, stir and control the temperature at 70°C, keep warm for 1.0h, evaporate the solvent under reduced pressure, wash and dry in vacuum to obtain white polylactic acid-polyglycolic acid (PLGA) powder;

[0034] (3) Weigh 0.2 grams of curcumin derivatives (L) and 1.8 grams of PLGA and dissolve them in 40 mL of chloroform, ultrasonically disperse them at 50°C for 1 hour and place them in a petri dish, and obtain uniform curcumin derivatives after the solvent evaporates - Polylactic acid-polyglycolic acid composite film (L-PLGA);

[0035] (4) The composite membrane was washed several times with ethanol and water respectively, and dried in a vacuum oven at 50° C. to obtain 10% solid object.

[0036] The experimental characteristics of the obtained target product refer to figure 1 — Image 6 As shown, specifically:

[0037] figure 1 The infrared ...

Embodiment 2

[0043] (1) 2 grams of polylactic acid and 3 grams of polyglycolic acid were completely dissolved in 50 mL of chloroform and 1,4-dioxane mixed solvent;

[0044] (2) Heat, stir and control the temperature at 60°C, keep warm for 1.5h, evaporate the solvent under reduced pressure, wash and dry in vacuum to obtain PLGA white powder;

[0045] (3) Weigh 0.4 g of curcumin derivative (L) and 3.8 g of PLGA, dissolve them in 80 mL of chloroform and 1,4-dioxane mixed solvent, and place them in a petri dish after ultrasonic dispersion at 60°C for 1.0 hour After the solvent evaporates, a uniform curcumin derivative-polylactic acid-polyglycolic acid composite film (L-PLGA) is obtained;

[0046] (4) The composite membrane was washed several times with ethanol and water respectively, and dried in a vacuum oven at 50° C. to obtain the solid object.

[0047] The experimental properties of the target product obtained in this embodiment 2 can also refer to Figure 1-Figure 6 Shown, not detailed....

Embodiment 3

[0049] (1) 3 grams of polylactic acid and 2 grams of polyglycolic acid are completely dissolved in 50 mL of tetrahydrofuran solvent;

[0050] (2) Heat, stir and control the temperature at 70°C, keep warm for 2.0 hours, evaporate the solvent under reduced pressure, wash and dry in vacuum to obtain PLGA white powder;

[0051] (3) Weigh 0.3 grams of curcumin derivatives (L) and 2.0 grams of PLGA and dissolve them in 40 mL of tetrahydrofuran solvent, and place them in a petri dish after reflux reaction at 80 ° C for 3.0 hours, and obtain uniform curcumin after the solvent evaporates Derivatives-polylactic acid-polyglycolic acid composite film (L-PLGA);

[0052] (4) The composite membrane was washed several times with ethanol and water respectively, and dried in a vacuum oven at 50° C. to obtain the solid object.

[0053] The experimental characteristics of the target product obtained in this embodiment 3 can also refer to Figure 1-Figure 6 Shown, not detailed.

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Abstract

The invention relates to a degradable curcumin derivative-polylactic acid-polyglycolic acid composite film, and a preparation method thereof. The preparation method comprises following steps: polylactic acid and polyglycolic acid at a certain mass ratio are completely dissolved in 30 to 100ml of an organic solvent respectively; heating stirring is carried out, the temperature is controlled to be 60 to 100 DEG C, thermal insulation reaction is carried out for 0.5 to 3.0h, reduced pressure evaporation is adopted to remove the solvent, and washing and vacuum drying are carried out so as to obtainPLGA (polylactic acid-polyglycolic acid) white powder; certain amounts of L (curcumin derivative) and PLGA are weighted, and are dissolved in an organic solvent at a certain mass ratio, ultrasonic dispersion is carried out for 1 to 3h at 40 to 60 DEG C (or backflow reaction is carried out for 2 to 5h at 60 to 90 DEG C), an obtained product is introduced into a culture dish, solvent volatilizationis carried out so as to obtain uniform L-PLGA; ethanol and water are adopted to wash the obtained composite film respectively for a plurality of times, the composite film is introduced into a vacuumdrying box for drying at 50 DEG C so as to obtain a solid stage target product. According to the preparation method, polylactic acid, polyglycolic acid, and the curcumin derivative are taken as main film forming materials; the obtained degradable curcumin derivative-polylactic acid-polyglycolic acid composite film can be degraded easily at normal temperature; the toxicity is low; fluorescence optical properties are improved obviously; the preparation method is simple, and is suitable for large scale production.

Description

technical field [0001] The invention relates to the technical field of new materials, in particular to a degradable curcumin derivative-polylactic acid-polyglycolic acid composite film and a preparation method thereof. Background technique [0002] Polylactic acid (PLA) is a linear thermoplastic polymer formed by direct polycondensation of lactic acid or ring-opening polymerization of lactic acid dimer lactide. It has good mechanical properties, thermoplasticity, biocompatibility and biodegradability, etc., so it is considered It is the green polymer material with the most development and application value in the 21st century. It is currently mainly used in the fields of controlled release materials, biomedical materials, tissue engineering materials and packaging materials. Due to the shortcomings of pure polylactic acid materials such as high brittleness, low heat deformation temperature and high gas permeability, it is generally modified by physical or chemical methods to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/34A61K47/59A61K47/69A61K31/12A61P35/00
CPCA61K9/7007A61K31/12A61K47/34A61K47/593A61K47/6953A61P35/00
Inventor 周双生汪佳凤司桂福
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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