Preparation method of biological material of macromolecule degradable drug carrier

A biomaterial and macromolecule technology, applied in the field of preparation of macromolecular degradable drug carrier biomaterials, can solve the problems of low clinical application rate, narrow scope of application and high development cost, and achieves easy availability of raw materials, strong practicability, The effect of high condition degradation performance

Inactive Publication Date: 2018-12-11
赵延延
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As far as the current situation is concerned, many drug carriers still have problems such as high development costs, low encapsulation efficiency, narrow application range, and low clinical application rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Add 5 parts of ethylene glycol, 22 parts of polylactic acid, 4 parts of polyacrylamide, 7 parts of polyhydroxyvalerate, and 2 parts of tetraisopropyl bis(dilauryl phosphite) titanate into ultrasonic Dispersion and coupling are carried out in the oscillator, and the obtained solution is sieved and sorted for use, wherein the ultrasonic power is 250KW, ultrasonic oscillation is 30min, and the sieve aperture is 2000 mesh;

[0025] (2) Add the solution of step (1) into a vacuum reactor, heat to 60°C and then add 2 parts of phosphatidylinositol, 2 parts of calcium chloride, 1 part of sodium alginate, and 3 parts of phosphatidylserine , 1 part of glycine, 1 part of dithiothreitol, and then the temperature rises to 100-105°C again, and the vacuum pressure is 5*10 -8 Pa, continue to react for 2 hours, after the reaction, the air pressure in the furnace returns to normal pressure, and the reactant is kept warm for standby;

[0026] (3) Inject the reaction solution of step (...

Embodiment 2

[0032] (1) Add 7 parts of ethylene glycol, 23 parts of polylactic acid, 5 parts of polyacrylamide, 9 parts of polyhydroxyvalerate, and 3 parts of titanium bis(dioctylpyrophosphoryl)oxyacetate into ultrasonic Dispersion and coupling are carried out in the oscillator, and the obtained solution is sieved and sorted for use, wherein the ultrasonic power is 250KW, the ultrasonic oscillation is 30min, and the sieve aperture is 2000 mesh;

[0033](2) Add the solution of step (1) into a vacuum reactor, heat to 60°C and then add 3 parts of phosphatidylinositol, 4 parts of calcium chloride, 2 parts of sodium alginate, and 4 parts of phosphatidylserine , 2 parts of glycine, 1 part of dithiothreitol, then the temperature rises to 100-105°C again, and the vacuum pressure is 5*10 -8 Pa, continue to react for 3 hours, after the reaction, the air pressure in the furnace returns to normal pressure, and the reactant is kept warm for standby;

[0034] (3) Inject the reaction solution of step (2...

Embodiment 3

[0040] (1) Add 9 parts of ethylene glycol, 24 parts of polylactic acid, 7 parts of polyacrylamide, 13 parts of polyhydroxyvalerate, and 4 parts of isopropyl tris(isostearyl) titanate into an ultrasonic oscillator Dispersion and coupling are carried out inside, and the obtained solution is sieved and sorted for later use, wherein the ultrasonic power is 250KW, the ultrasonic oscillation is 30min, and the sieve aperture is 2000 mesh;

[0041] (2) Add the solution of step (1) into a vacuum reactor, heat to 60°C, and then add 3 parts of phosphatidylinositol, 5 parts of calcium chloride, 2 parts of sodium alginate, and 5 parts of phosphatidylserine , 3 parts of glycine, 2 parts of dithiothreitol, and then the temperature rises to 100-105°C again, and the vacuum pressure is 5*10 -8 Pa, continue to react for 4h, after the reaction, the air pressure in the furnace returns to normal pressure, and the reactant is kept warm for standby;

[0042] (3) Inject the reaction solution of step ...

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PUM

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Abstract

The invention discloses a preparation method of a biological material of a macromolecule degradable drug carrier. According to the process, the biological material of a macromolecule degradable drug carrier is prepared by performing the steps of ultrasonic oscillating and dispersing, sieving and sorting, vacuum heating and reaction, injection molding and die pressing, cooling and fixing, ultrasonic cleaning, positive and negative polyelectrolyte aqueous solution adsorption balancing, washing and airing, nitrogen-protected curing and the like on materials including ethylene glycol, polylactic acid, polypropylene ammonia, polyhydroxyvalerate, phosphatidylinositol, calcium chloride, sodium alginate, phosphatidylserine, glycine, dithiothreitol and the like. The prepared biological material ofa macromolecule degradable drug carrier has relatively high condition degradation performance, and is steady and non-toxic, and suitable for application to multiple materials related to drug carriers.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a preparation method of biodegradable polymer carrier biomaterials. Background technique [0002] A drug carrier refers to a system that can change the way a drug enters the human body and its distribution in the body, controls the release rate of the drug, and delivers the drug to the target organ. Drug carrier materials play a very important role in the research of controlled-release preparations. Since the 1960s, research on drug-controlled release systems has attracted widespread attention. Drug controlled release system can improve the utilization rate, safety and effectiveness of drugs, which can reduce the frequency of dosing, so it has attracted attention. Among drug carriers, biopolymers derived from animals, plants and microorganisms have become an important class of drug carrier materials because of their good biocompatibility, biodegradability and reproducibilit...

Claims

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Application Information

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IPC IPC(8): C08G83/00C08J7/12A61K47/30C08L87/00
CPCA61K47/30C08G83/00C08J7/12C08J7/123C08J2387/00
Inventor赵延延
Owner赵延延