A method for making microfluidic chip molds by using numerical control engraving technology combined with paraffin substrates

A technology of microfluidic chip and numerical control engraving machine, applied in the field of micromachining, can solve the problems of restricting the development and practical application of microfluidic technology, harsh processing environment, complex processing process, etc., to accelerate research and practical application, and easy to operate. , The effect of low processing cost

Active Publication Date: 2020-11-06
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional microfluidic chip mold making methods include SU-8 mold making based on photolithography technology, metal mold making based on LIGA (Lithographie galvanoformung abformung) technology and micro-electroforming technology. Long, expensive equipment and harsh processing environment, these defects greatly limit the development and practical application of microfluidic technology to a certain extent

Method used

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  • A method for making microfluidic chip molds by using numerical control engraving technology combined with paraffin substrates
  • A method for making microfluidic chip molds by using numerical control engraving technology combined with paraffin substrates
  • A method for making microfluidic chip molds by using numerical control engraving technology combined with paraffin substrates

Examples

Experimental program
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Effect test

Embodiment 1

[0053] To make a focused droplet microfluidic chip mold based on epoxy glue, the specific steps are:

[0054](1) Production of paraffin substrate: A hollowed glass plate and another flat glass plate are bonded with double-sided tape to form a flat plate with a cavity; the plate is placed on a 100°C hot plate, and the cavity Inject melted microcrystalline wax into the cavity so that the paraffin liquid level is slightly higher than the upper surface of the cavity; then press a piece of film and a flat glass plate on the paraffin liquid; turn off the power supply of the hot plate to cool and solidify the paraffin liquid; wait for the paraffin to cool After reaching room temperature, remove the glass cover and peel off the film to obtain a paraffin substrate with a smooth surface. The preparation process is as follows: figure 2 shown.

[0055] (2) Paraffin wax master mold engraving: First, use AutoCAD software to draw the pipeline graphics of the focused droplet microfluidic ch...

Embodiment 2

[0059] To make a focused droplet microfluidic chip mold based on ultraviolet glue, the specific steps are:

[0060] (1) Production of paraffin substrate: A hollowed glass plate and another flat glass plate are bonded with double-sided tape to form a flat plate with a cavity; the plate is placed on a 100°C hot plate, and the cavity Inject melted microcrystalline wax into the cavity so that the paraffin liquid level is slightly higher than the upper surface of the cavity; then press a piece of film and a flat glass plate on the paraffin liquid; turn off the power supply of the hot plate to cool and solidify the paraffin liquid; wait for the paraffin to cool After reaching room temperature, remove the glass cover and peel off the film to obtain a paraffin substrate with a smooth surface. The preparation process is as follows: figure 2 shown.

[0061] (2) Paraffin wax master mold engraving: First, use AutoCAD software to draw the pipeline graphics of the focused droplet microflu...

Embodiment 3

[0065] To make a focused droplet microfluidic chip mold based on alumina ceramics, the specific steps are:

[0066] (1) Production of paraffin substrate: A hollowed glass plate and another flat glass plate are bonded with double-sided tape to form a flat plate with a cavity; the plate is placed on a 100°C hot plate, and the cavity Inject melted microcrystalline wax into the cavity so that the paraffin liquid level is slightly higher than the upper surface of the cavity; then press a piece of film and a flat glass plate on the paraffin liquid; turn off the power supply of the hot plate to cool and solidify the paraffin liquid; wait for the paraffin to cool After reaching room temperature, the glass cover plate was removed, and the film was peeled off to obtain a paraffin substrate with a smooth surface.

[0067] (2) Paraffin wax master mold engraving: First, use AutoCAD software to draw the pipeline graphics of the focused droplet microfluidic chip. The width and depth of the w...

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Abstract

The invention discloses a method for manufacturing a micro-fluidic chip die through combination of a numerical control carving technology and a paraffin substrate, and belongs to the field of micromachining. According to the method, a micro-fluidic chip pattern drawn through drawing software is etched on the paraffin substrate, and a paraffin female die is formed; the surface coating technology isutilized for improving the smoothness of the surface of the paraffin female die; and finally, the micro-fluidic chip die is manufactured through a pouring die inversing method. According to the method, on one hand, the characteristic that the hardness of paraffin is low is utilized, the phenomenon of cutter fracture is not likely to happen when an ultrafine-diameter cutter is used for machining amicro pipeline or micro cavity structure, and accordingly the micro-fluidic chip die with the finer structure can be prepared; and on the other hand, operation is simple, only the steps of AutoCAD chip design, carving machine machining, surface coating, pouring die reversing and the like are needed, the micro-fluidic chip die machining time can be greatly shortened, and the micro-fluidic chip diemachining cost can be greatly reduced. The method for manufacturing the micro-fluidic chip die is suitable for small-batch production or laboratory level machining of micro-fluidic chips.

Description

technical field [0001] The invention belongs to the field of micromachining, and in particular relates to a method for manufacturing a microfluidic chip mold by using numerical control engraving technology combined with a paraffin substrate. Background technique [0002] In recent years, microfluidic technology, as a new technology platform, has received extensive attention in the fields of biology and chemistry, and is one of the most active fields of development. For microfluidic technology, the processing and fabrication of microfluidic chips is the premise and basis for its application. At present, the matrix materials for making microfluidic chips mainly fall into three categories: silicon, glass and polymers. Among them, silicon and glass chips are usually realized by microelectronics processing technology combined with wet etching. The specific process includes the production of mask plate, photolithography patterning (lithography process includes glue coating, glue ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C33/38B28B1/26
CPCB28B1/26B29C33/3842
Inventor 李刚刘小龙库晓永
Owner CHONGQING UNIV
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