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Proliferative agent for bacteria of genus faecalibacterium

A proliferating agent and bacillus technology, applied in the direction of bacteria, anti-inflammatory agents, non-central analgesics, etc., can solve safety concerns and other issues, and achieve high safety and high water solubility

Inactive Publication Date: 2018-12-21
B FOOD SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(ii) Generally speaking, exogenous bacteria are difficult to fix in the intestine, and most of them will pass through the digestive tract, so the effect is considered to be temporary
(iii) Faecalibacterium has no history of eating experience, so there are concerns about safety. (iv) Faecalibacterium is obligate anaerobic, so in order to mix it in the state of living bacteria, it is necessary to Special processing and storage conditions

Method used

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  • Proliferative agent for bacteria of genus faecalibacterium
  • Proliferative agent for bacteria of genus faecalibacterium
  • Proliferative agent for bacteria of genus faecalibacterium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Research on the Proliferation of Faecalibacterium Bacteria in Vitro

[0049] A liquid medium having the following composition was aseptically prepared. As various oligosaccharides, 1-kestose (purity 99% by mass; Bussan Food Technology Co., Ltd.), kestetose (purity 98% by mass; Wako Pure Chemicals), xylooligosaccharide (purity 98% by mass; Wuchan Food Science and Technology Co., Ltd.), raffinose (purity: 98% by mass; Meiji Food Materia Co., Ltd.), or lactulose (purity: 89% by mass; Yanshuigang Refined Sugar Co., Ltd.). In addition, as a control, a liquid medium containing no oligosaccharide in the following composition was prepared in the same manner.

[0050] "Composition of liquid medium / per 1L" (final pH: pH7.0)

[0051] Casein decomposition product 15.0g, yeast extract 5.0g, L-cystine 0.5g, sodium chloride 2.5g, thioglycolic acid 0.5g, tryptophan 25mg, appropriate amount of hemin (Hemin), appropriate amount of vitamin K1, Various oligosaccharides 5.0g.

...

Embodiment 2

[0061] Research on the Proliferation of Faecalibacterium Bacteria in Organisms

[0062] Divide 58 infants aged 6 months to 6 years into 2 groups, 29 in each group, as 1-kestose group and maltose group. During the test period, the 1-kestose group took 1-kestose (purity 98% by mass or more; Wuchan Food Technology Co., Ltd.) every day, and the maltose group took maltose (purity 92% by mass) orally every day. above; "sunmalt-S" powder; Sanwa Starch Industry Co., Ltd.). The test period was set to 12 weeks. The 1-day intake of 1-kestose or maltose is 1g (standard intake; 0.121g / kg body weight / day) when less than 1 year old, and 2g (standard intake; 0.169g / day) when 1-3 years old kg body weight / day), 3g (standard intake; 0.170g / kg body weight / day) at the age of 4 to 6 years. Feces were recovered at the beginning (0 week), at the lapse of 6 weeks (6 weeks) and at the lapse of 12 weeks (12 weeks) of the test period.

[0063] In addition, the above-mentioned standard intake i...

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Abstract

The subject of the invention is to provide a substance and method that are capable of effectively inducing proliferation in bacteria of the genus Faecalibacterium, thereby contributing to the prevention and treatment of diseases such as enterocolitis. The solution to the subject of the invention is a proliferative agent for bacteria of the genus Faecalibacterium that contains 1-kestose as an active ingredient. In accordance with the invention, proliferation can be effectively induced in bacteria of the genus Faecalibacterium both in vitro and in vivo. In particular, it is possible to simply and effectively increase in vivo proliferation of bacteria of the genus Faecalibacterium in humans and animals, with almost no concerns regarding side effects or safety. It is also possible to prevent or treat enterocolitis by increasing in vivo proliferation of bacteria of the genus Faecalibacterium in humans and animals.

Description

technical field [0001] The present invention relates to an agent for proliferating Faecalibacterium bacteria containing 1-kestose as an active ingredient, a food composition for growing Faecalibacterium bacteria, a method for growing Faecalibacterium bacteria, and a method for treating or preventing intestinal inflammation , and the application of 1-kestose for the manufacture of medicines for the treatment or prevention of intestinal inflammation. Background technique [0002] Faecalibacterium bacteria are obligate anaerobic bacilli resident in the mucous layer of the intestine. The retention rate and number of retention in humans are high, and they are the main constituent bacteria of the intestinal flora. Recent studies have shown that Faecalibacterium bacteria have preferable physiological functions such as supplying energy to intestinal cells, maintaining a good intestinal environment, and strong anti-inflammatory effects (Non-Patent Document 1). Furthermore, regarding...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A23L33/135A61P1/04C12N1/20
CPCC12N1/20A61K31/702A23L33/125A61P1/04A61P29/00A61P1/00A23V2002/00A23V2200/32A23L33/135A23L33/10
Inventor 栃尾巧佐藤冬彦小西健太古贺泰裕远藤明仁
Owner B FOOD SCI