A kind of antibacterial micro-nano particles with adhesion function and its preparation method and application
A micro-nano particle and functional technology, applied in the field of antibacterial materials, can solve the problem of difficult to cure bacterial infection, and achieve the effect of controlling bacterial infection, excellent antibacterial effect, and improving antibacterial properties
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Embodiment 1
[0013] 1. Synthesis of dopamine methacrylamide (DMA)
[0014] Weigh 10g of sodium borate and 4g of sodium carbonate, dissolve them in 100mL of deionized water and add them to a 250mL three-neck flask, stir to dissolve, and the sodium borate and sodium carbonate are supersaturated. Nitrogen gas was bubbled for 20 minutes to remove all the oxygen in the solution, and 5 g of dopamine hydrochloride was added to continue stirring until dissolved. Dissolve 4.7mL of methacrylic anhydride in 25mL of tetrahydrofuran and slowly add it dropwise into a three-neck flask. After the dropwise addition, adjust the pH to above 8 with 1M sodium hydroxide to protect the phenolic hydroxyl group of dopamine. The reaction was stirred and ventilated at room temperature for 14 h, and the obtained product was a white suspension. The post-processing is as follows: filter the reaction product with suction to remove excess salt, then adjust the pH to 2 with 6M salt, then extract with 50 mL of ethyl aceta...
Embodiment 2
[0023] The total amount of fixed DMA and EMA is 0.15mol / L, and the solvent is a mixed solvent of ethanol / water volume ratio 5 / 5, a total of 10mL. Weigh an appropriate amount of DMA and EMA into a 10mL polymerization tube, degas and remove oxygen for 20min, and seal it. Weigh 0.00656g AIBN and dissolve it in 10mL ethanol, take 1mL initiator solution and add it to the polymerization tube under the protection of nitrogen after ventilating for 20min. After the reactants are completely dissolved, continue to add 9mL of deionized water, mix evenly, and stand in the dark for 10 hours at 80°C. Post-processing was as follows: precipitate the reaction product in a 50 mL centrifuge tube containing 40 mL deionized water, centrifuge several times, remove the supernatant, freeze-dry the sediment for 24 hours, and the final product is a white powder.
Embodiment 3
[0025] The total amount of fixed DMA and EMA is 0.08mol / L, and the solvent is a mixed solvent of ethanol / water volume ratio 1 / 10, a total of 10mL. Weigh an appropriate amount of DMA and EMA into a 10mL polymerization tube, degas and remove oxygen for 20min, and seal it. Weigh 0.00495g AIBN and dissolve it in 10mL ethanol, take 1mL initiator solution and add it to the polymerization tube under the protection of nitrogen after ventilating for 20min. After the reactants are completely dissolved, continue to add 9mL of deionized water, mix well, and stand in the dark at 75°C for 6 hours. Post-processing was as follows: precipitate the reaction product in a 50 mL centrifuge tube containing 40 mL deionized water, centrifuge several times, remove the supernatant, freeze-dry the sediment for 24 hours, and the final product is a white powder.
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