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Cellulose enhanced glucan-based injectable antibacterial hydrogel dressing and preparation method thereof

A technology of dextran and cellulose, which is applied in the field of cellulose-reinforced dextran-based injectable antibacterial hydrogel dressings and its preparation, can solve problems such as chronic wound healing obstacles, promote rapid healing, and remove free radicals , to avoid the effect of toxic side effects

Active Publication Date: 2019-01-08
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under the protection of biofilm and surrounding drug-resistant flora, usually non-pathogenic microorganisms can also develop antibiotic resistance, which has brought great obstacles to the healing of chronic wounds

Method used

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  • Cellulose enhanced glucan-based injectable antibacterial hydrogel dressing and preparation method thereof
  • Cellulose enhanced glucan-based injectable antibacterial hydrogel dressing and preparation method thereof
  • Cellulose enhanced glucan-based injectable antibacterial hydrogel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of a cellulose-reinforced dextran-based injectable antibacterial hydrogel dressing is as follows:

[0034] a) Preparation of aminated dextran:

[0035] Di-tert-butyl dicarbonate (10 g, 0.0459 mol) was dissolved in dichloromethane (120 mL), and then ethylenediamine ( figure 1 Structural formula 1) (16.5g, 0.275mol), react at 0°C for 6-24 hours, remove dichloromethane with a rotary evaporator, then wash with 100mL saturated brine, then extract three times with 200mL ethyl acetate, and combine the organic layers , and dried overnight with anhydrous magnesium sulfate, filtered with suction, and removed ethyl acetate with a rotary evaporator to obtain the product ( figure 1 Structural formula 2).

[0036] At 90°C, the dextran ( figure 1 Structural formula 3) 2g is dissolved in the mixed solution of lithium chloride and N,N-dimethylformamide (the content of lithium chloride is 50%wt), after the dextran is completely dissolved, the solution is lowered t...

Embodiment 2

[0052] A preparation method of cellulose-enhanced dextran-based injectable antibacterial hydrogel dressing:

[0053] The difference between this embodiment and embodiment 1 is:

[0054] Step a) is:

[0055] Di-tert-butyl dicarbonate (10 g, 0.0459 mol) was dissolved in dichloromethane (120 mL), and then ethylenediamine ( figure 1 Structural formula 1) (16.5g, 0.275mol), react at 0°C for 6-24 hours, remove dichloromethane with a rotary evaporator, then wash with 100mL saturated brine, then extract three times with 200mL ethyl acetate, and combine the organic layers , and dried overnight with anhydrous magnesium sulfate, filtered with suction, and removed ethyl acetate with a rotary evaporator to obtain the product ( figure 1 Structural formula 2).

[0056] At 90°C, the dextran ( figure 1 Structural formula 3) 2g is dissolved in the mixed solution of lithium chloride and N,N-dimethylformamide (the content of lithium chloride is 50%wt), after the dextran is completely dissolve...

Embodiment 3

[0059] A preparation method of cellulose-enhanced dextran-based injectable antibacterial hydrogel dressing:

[0060] The difference between this embodiment and embodiment 1 is:

[0061] Step a) is:

[0062] Di-tert-butyl dicarbonate (10 g, 0.0459 mol) was dissolved in dichloromethane (120 mL), and then hexamethylenediamine dissolved in dichloromethane (120 mL) was added dropwise ( figure 1 Structural formula 1) (31.96g, 0.275mol), react at 0°C for 6-24 hours, remove dichloromethane with a rotary evaporator, then wash with 100mL saturated brine, then extract three times with 200mL ethyl acetate, and combine the organic layers , and dried overnight with anhydrous magnesium sulfate, filtered with suction, and removed ethyl acetate with a rotary evaporator to obtain the product ( figure 1 Structural formula 2).

[0063] At 90°C, the dextran ( figure 1 Structural formula 3) 2g is dissolved in the mixed solution of lithium chloride and N,N-dimethylformamide (the content of lithi...

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Abstract

The invention discloses cellulose enhanced glucan-based injectable antibacterial hydrogel dressing and a preparation method thereof. The hydrogel is obtained by crosslinking aminated glucan and aldehyde glucan at the body temperature of a human body, and modified cellulose short fiber and polypeptide are distributed in the hydrogel. The preparation method comprises the following steps: reacting the glucan with anhydride, and removing BOC to obtain glucan containing multi-amino; selectively oxidizing the glucan into the aldehyde glucan by an oxidizing agent; and preparing aqueous solutions fromthe glucan containing multi-amino and the aldehyde glucan correspondingly, mixing the aqueous solutions, adding modified cellulose short fiber and solid-phase synthesized polypeptide, and preparing the cellulose enhanced glucan-based injectable antibacterial hydrogel dressing under the condition of the body temperature of the human body. The cellulose enhanced glucan-based injectable antibacterial hydrogel dressing has high mechanical property, has excellent biocompatibility and antibacterial property, has excellent compression-resistant and elastic properties, can promote rapid healing of wound and is suitable for wound treatment and repair of chronic skin ulcer with different depth.

Description

technical field [0001] The invention relates to a cellulose-reinforced dextran-based injectable antibacterial hydrogel dressing and a preparation method thereof, belonging to the technical field of medical materials and preparation thereof. Background technique [0002] Deep skin ulcer is a deep skin and mucous membrane tissue defect caused by exogenous microbial infection, blood circulation disorder, immune function abnormality or congenital skin defect. Such ulcer wounds are difficult to heal, and clinical treatment takes at least 8 weeks. The causes of deep ulceration of the skin are more complicated, and infection is one of its important influencing factors. Studies have shown that the formation of bacterial biofilms is the main cause and exacerbation of such infections. The skin has a self-healing function, but once the wound surface reaches the deep wound level, its repair function will be seriously reduced. Therefore, people use dressings to assist wound surface rep...

Claims

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Application Information

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IPC IPC(8): A61L15/22A61L15/42A61L15/44A61L15/46
CPCA61L15/225A61L15/42A61L15/44A61L15/46A61L2300/404A61L2300/412A61L2400/06C08L5/02C08L1/02C08L89/00
Inventor 吴德群仇威王朱婕李发学王学利俞建勇
Owner DONGHUA UNIV
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