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Preparation method and application of molecularly imprinted polymer-ferric oxide electrochemiluminescence sensor

A technology of ferroferric oxide and electrochemistry, which is applied in the direction of chemiluminescence/bioluminescence, electrochemical variables of materials, and analysis through chemical reactions of materials, etc. The preparation method and application of electrochemiluminescent sensors to achieve the effect of improving stability

Active Publication Date: 2020-10-30
NINGBO UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no related research reports on the preparation method and application of electrochemiluminescent sensors based on molecularly imprinted polymer-ferric oxide at home and abroad.

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  • Preparation method and application of molecularly imprinted polymer-ferric oxide electrochemiluminescence sensor
  • Preparation method and application of molecularly imprinted polymer-ferric oxide electrochemiluminescence sensor
  • Preparation method and application of molecularly imprinted polymer-ferric oxide electrochemiluminescence sensor

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specific Embodiment 1

[0036] The preparation method of the electrochemiluminescent sensor based on molecularly imprinted polymer-ferric oxide, the specific steps are as follows:

[0037] (1) Fe 3 o 4 nanocrystals (Fe 3 o 4 -NCs) preparation

[0038] A. Preparation of iron oleate precursor solution: weigh 2.53g of FeCl 3 ·6H 2 O was dissolved in 25mL of secondary water; 8.86mL of oleic acid was dissolved in 32mL of ethanol; the above two solutions were mixed and added to a three-necked flask, stirred at 70°C for 4 hours, the solution was divided into two layers, and the oil containing The upper layer of the acid-iron complex is washed 3 times in a separatory funnel with deionized water, and then the n-hexane is removed under vacuum conditions to obtain a waxy solid which is the iron-oleate complex;

[0039] B. Dissolve 1mL of iron oleate complex, 3mL of n-trioctylamine (TOA) in 8mL of octadecene (ODE), put the mixture in a three-necked flask, vacuumize at 100°C for 1 hour, and then in Under...

specific Embodiment 2

[0052] Condition optimization of molecular imprinting-electrochemiluminescence detection system, in which luminol concentration, polymer concentration, PBS buffer concentration and system pH value have important influence on electrochemiluminescence signal intensity and system sensitivity, selectivity and stability .

[0053] 1. Effect of luminol concentration on the intensity of electrochemiluminescence

[0054] As a luminescent precursor substance, the concentration of luminol is crucial to whether the system can produce continuous and stable optical signals. Therefore, the experiment first investigated the influence of the concentration of 0.2-1.0mM luminol on the intensity of electrochemiluminescence of the system. From Figure 8 It can be seen that as the concentration of luminol increases, the value of the electrochemiluminescence signal increases continuously. When the luminol concentration increased to 0.6mM, the relative luminous intensity of the system was the lar...

specific Embodiment 3

[0062] The method for detecting the concentration of bisphenol A using the electrochemiluminescence sensor for detecting bisphenol A prepared under the optimized conditions of the above specific embodiment 1 and specific embodiment 2, the specific steps are as follows:

[0063] The electrochemiluminescence test was carried out in a self-made Teflon electrolytic cell, the base was made of transparent quartz material, and the volume was 10.0mL. The electrochemiluminescence sensor based on molecularly imprinted polymer-ferric oxide is used as the working electrode, the platinum wire electrode is used as the auxiliary electrode (counter electrode), and Ag / AgCl (KCl saturated solution saturated with AgCl) is used as the reference electrode, using MPI -E-type electrochemiluminescence system for electrochemiluminescence analysis; system conditions: PBS buffer concentration is 60mM, pH is 10.0, luminol concentration is 0.6mM; instrument conditions: photomultiplier tube negative high vo...

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Abstract

The invention discloses a preparation method and application of a molecularly imprinted polymer-ferroferric oxide-based electrochemiluminescence sensor. The preparation method is characterized by comprising the following steps of: preparing Fe3O4 nanocrystals; sequentially adding cyclohexane, TritonX-100, a Fe3O4-NCs solution, TEOS and ammonia water into in a fixed two-necked flask, reacting by stirring for 2h, then adding a BPA (Bis Phenol-A) template molecule acetonitrile solution and 3-aminopropyltriethoxysilane, reacting for 12h, and washing so as to facilitate the falling of template molecules, thereby obtaining precipitate, namely Fe3O4-NCs-MIPs; and sequentially dropping a Fe3O4-NCs-MIPs solution and a perfluorosulfonic acid ethanol solution onto the surface of a glassy carbon electrode to obtain a working electrode Nafion / Fe3O4-NCs-MIPs / GCE. The preparation method has the advantages of good selectivity, stability and high sensitivity.

Description

technical field [0001] The invention relates to an electrochemiluminescence sensor, in particular to a preparation method and application of an electrochemiluminescence sensor based on a molecularly imprinted polymer-ferric oxide. Background technique [0002] Bisphenol A, namely 4, 4-dihydroxydiphenylpropane (BPA for short), is an environmental endocrine disrupting chemical (endorsing disrupting chemicals, EDCs) with estrogen activity, which causes serious pollution and harm to the ecological environment. Bisphenol A is one of the most widely used industrial compounds in the world, mainly used in the production of polycarbonate, epoxy resin, rubber anti-aging agent, coating and other polymer materials and fine chemical products. The addition of bisphenol A can make plastic products colorless, transparent, durable, lightweight and good impact resistance, so it is widely used in the packaging of canned food and beverages, baby bottles, water cups, sealants for dental fillings...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/76G01N27/30
CPCG01N21/76G01N27/308
Inventor 史西志柴继业孙爱丽徐锦锦刘晨曦
Owner NINGBO UNIV
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