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Large-size silver-loaded hydroxyapatite porous microsphere material and preparation method thereof

A porous microsphere, large-scale technology, applied in chemical instruments and methods, phosphorus compounds, pharmaceutical formulations, etc., can solve problems such as lack of antibacterial activity, and achieve the effect of avoiding secondary treatment, good sphericity, and uniform size

Inactive Publication Date: 2019-01-15
SHANDONG JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are literatures (Wei Xiao, Hailuo Fu, et al. Hollow hydroxyapatite microspheres: A novel bioactive and osteoconductive carrier for controlled release of bone morphogenetic protein-2 in bone regeneration.) prepared hollow mesoporous HA microspheres (106~ 150μm), the microsphere pore size is only 10-20nm, and has no antibacterial activity

Method used

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  • Large-size silver-loaded hydroxyapatite porous microsphere material and preparation method thereof
  • Large-size silver-loaded hydroxyapatite porous microsphere material and preparation method thereof
  • Large-size silver-loaded hydroxyapatite porous microsphere material and preparation method thereof

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Embodiment 1

[0051] The synthetic reaction raw material of a kind of large-scale Ag-HA porous microsphere material mainly comprises several reagents of following amount: n[Ca(NO 3 ) 2 4H 2 O]:n[(NH 4 ) 2 HPO 4 ]: n[L-glutamic acid]=10.8:6:15, urea 1mol / L, AgNO 3 The powder is added according to the atomic ratio Ag / [Ag+Ca]=2%, HNO 3 : 0.05mol / L, the solvent is deionized water.

[0052] The preparation method of above-mentioned precursor solution is as follows: first Ca(NO 3 ) 2 4H 2 O, (NH 4 ) 2 HPO 4 , three solutions of urea were mixed in a beaker, stirred evenly by magnetic force and then added dilute HNO 3 Adjust the pH of the solution; then add L-glutamic acid to the solution and stir well, then add AgNO 3 Stir the powder, and finally pour the above mixture into a polytetrafluoroethylene-lined kettle, place it in a blast drying oven, and set the reaction temperature and reaction time to 160°C and 6h, respectively. After the reaction was completed, the reaction vessel was ...

Embodiment 2

[0055] The synthetic reaction raw material of a kind of large-scale Ag-HA porous microsphere material mainly comprises several reagents of following amount: n[Ca(NO 3 ) 2 4H 2 O]:n[(NH 4 ) 2 HPO 4 ]: n[L-glutamic acid]=10.8:6:15, urea 1mol / L, AgNO 3 The powder is added according to the atomic ratio Ag / [Ag+Ca]=4%, HNO 3 : 0.05mol / L, the solvent is deionized water.

[0056] The preparation method of above-mentioned precursor solution is as follows: first Ca(NO 3 ) 2 4H 2 O, (NH 4 ) 2 HPO 4 , three solutions of urea were mixed in a beaker, stirred evenly by magnetic force and then added dilute HNO 3 Adjust the pH of the solution; then add L-glutamic acid to the solution and stir well, then add AgNO 3 Stir the powder, and finally pour the above mixture into a polytetrafluoroethylene-lined kettle, place it in a blast drying oven, and set the reaction temperature and reaction time to 160°C and 6h, respectively. After the reaction was completed, the reaction vessel was ...

Embodiment 3

[0058] The synthetic reaction raw material of a kind of large-scale Ag-HA porous microsphere material mainly comprises several reagents of following amount: n[Ca(NO 3 ) 2 4H 2 O]:n[(NH 4 ) 2 HPO 4 ]: n[L-glutamic acid]=10.8:6:15, urea 1mol / L, AgNO 3 The powder is added according to the atomic ratio Ag / [Ag+Ca]=6%, HNO 3 : 0.05mol / L, the solvent is deionized water.

[0059] The preparation method of above-mentioned precursor solution is as follows: first Ca(NO 3 ) 2 4H 2 O, (NH 4 ) 2 HPO 4 , three solutions of urea were mixed in a beaker, stirred evenly by magnetic force and then added dilute HNO 3 Adjust the pH of the solution; then add L-glutamic acid to the solution and stir well, then add AgNO 3 Stir the powder, and finally pour the above mixture into a polytetrafluoroethylene-lined kettle, place it in a blast drying oven, and set the reaction temperature and reaction time to 160°C and 6h, respectively. After the reaction was completed, the reaction vessel was ...

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Abstract

The invention belongs to the field of inorganic biomedical materials, and relates to a large-size silver-loaded hydroxyapatite porous microsphere material and a preparation method thereof. The preparation method comprises the following steps that firstly, soluble calcium salt, soluble dibasic hydrogen phosphate and a urea solution are mixed and are adjusted to be clear by using a nitric acid solution, then L-glutamic acid is added so as to obtain a precursor solution, then soluble silver salt is added into the precursor solution, and hydrothermal reaction is carried out on an obtained mixed solution so as to obtain a silver-ion-doped HA porous microsphere. According to the large-size silver-loaded hydroxyapatite porous microsphere material and the preparation method thereof, the silver doping step and sequence are designed so as to obtain the large-size silver-ion-doped HA porous microsphere with the particle size of 30-100 microns, being porous with pores communicated with one anotherand with the surface composed of flaky crystals, and the microsphere can be used as an antibacterial drug controlled release carrier, an injectable osteanagenesis biological material and an implant for loading a cell / drug in the biological antibacterial field.

Description

technical field [0001] The invention belongs to the field of inorganic biomedical materials, and relates to a large-size silver-loaded hydroxyapatite porous microsphere material and a preparation method thereof. Background technique [0002] Hydroxyapatite (HA) is a bioactive ceramic material commonly used in clinical practice due to its excellent biocompatibility, bioactivity, non-toxic, non-irritating, and non-inflammatory properties. The morphology of HA has an important impact on its application. Most of the granular HA materials used at the beginning are obtained by crushing block HA and sieving. They have irregular shapes, which can easily cause tissue infection and slow new bone growth. . It has been reported that HA materials in various forms such as spherical, needle-like, rod-like, flake-like, dumbbell-like, and whisker-like have been prepared. Among them, the spherical shape of HA not only has the general characteristics of HA, but also shows better fluidity. An...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B22F9/24A61L27/42A61L27/50A61L27/54A61L27/56A61K47/02A61P31/04
CPCA61K47/02A61L27/425A61L27/50A61L27/54A61L27/56A61L2300/104A61L2300/404A61L2400/06A61P31/04B22F9/24C01B25/325C01P2002/72C01P2004/03
Inventor 齐美丽王彦敏陈敏张爱勤马丽
Owner SHANDONG JIAOTONG UNIV
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