Enzymatic resolution method for preparation of (R)-1-(1-naphthyl) ethylamine

A technology of enzymatic separation and naphthyl, which is applied in the field of chemical enzymatic preparation of -1-ethylamine, can solve the problems of slow reaction speed of enzymatic method and easy falling off of palladium catalyst, and achieve high reusability and separation effect Excellent, good high temperature performance effect
CN109234352AInactive Publication Date: 2019-01-18JIANGSU UNIV OF TECH
11 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU UNIV OF TECH
Publication Date
2019-01-18
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a chemical enzymatic method for preparing (R)-1-(1-naphthyl) ethylamine, wherein the nano palladium is supported by a solid superbase to obtain immobilized palladium; Candida Antarctica lipase B (CALB) was covalently bound to the surface of epoxy resin carrier to obtain immobilized CALB. In reaction system A, immobilized CALB was used as catalyst, toluene as solvent, ethoxyacetate as acyl donor, (R)-1-(1-naphthyl) ethylamine is selectively esterified, solid-liquid separation is carried out after the reaction, immobilized CALB is left in the reaction system A, liquid phase is removed from the reaction system A into the reaction system B, and the palladium catalyst is immobilized by the method, so that the reuse rate of the palladium catalyst is increased.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a biological resolution method, in particular to a chemical and enzymatic preparation method of (R)-1-(1-naphthyl)ethylamine. Background technique

[0002] (R)-1-(1-naphthyl)ethylamine is an important chiral block for preparation, and the current methods for the resolution and preparation of (R)-1-(1-naphthyl)ethylamine mainly include chemical and enzymatic methods :

[0003] Chemical resolution method: L-aspartic acid (CN101407465A), chiral naproxen (such as international patent document WO2008058235A2), chiral tartaric acid (such as international patent document WO2004110976A2, Chinese patent document CN101735070A, Chinese patent document CN103420845A), etc. The chiral resolving agent forms a salt with 1-(1-naphthyl)ethylamine racemate, and the solubility of different chiral 1-(1-naphthyl)ethylamine salts in solvents is different, and the (S) -1-(1-naphthyl)ethylamine and (R)-1-(1-naphthyl)ethylamine were separated. The pr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More