3D printing Ti-PMMA-vancomycin anti-infection bone scaffold, and preparation method and application thereof

Abstract

The invention relates to a 3D printing Ti-PMMA-Vancomycin anti-infectious bone scaffold, a preparation method and an application, belongs to human implant, and provides a bone defect filling scaffoldmaterial with the anti-infectious property and a preparation method thereof, which is used for treating acute and chronic infection of bone tissue. It uses titanium alloy, polymethyl methacrylate as the base material and vancomycin as the anti-infective drug to achieve the function of anti-infective and filling bone defect. The invention has the advantages of simple and reliable structure, controllable shape and microstructure, reliable mechanical performance, controllable drug release performance, convenient implantation, small trauma and low cost.

Description

technical field [0001] The invention relates to a 3D printed Ti-PMMA-vancomycin anti-infection bone scaffold and its preparation method and application, which belongs to the implant in the human body and can be used to treat various pathogenic bacteria, such as: Staphylococcus aureus, Streptococcus suppurativa Acute and chronic osteomyelitis, septic arthritis bone destruction caused by coccus, β-hemolytic streptococcus, bacillus anthracis, diphtheria bacillus, etc., and treatment of bone defects after infection. Background technique [0002] Infection is defined as a disruption of the balance between the host tissue and the local concentration of microorganisms, generally considered to be greater than 10 5 Each gram of tissue or the presence of pathogenic bacteria such as Staphylococcus aureus, Streptococcus pyogenes, and β-hemolytic streptococcus is considered to be an infection. Among many infectious diseases, bone and joint infection is not only a common and frequently-o...

AI Technical Summary

Problems solved by technology

[0004] The current clinical classic treatment strategy is to mix polymethylmethacrylate (PMMA) with antibiotics to make PMMA-antibiotic bead chains and fill them in the infected bone defect area for the treatment of infection, but the PMMA obtained by this method - Antibiotic bead chains, whose shape, internal structure and physical and chemical properties cannot be accurately controlled, cannot well match the complex anatomical shape and biomechanical environment of the area to be implanted, and the mechanical properties of PMMA are insufficient, and it is difficult to meet the requirements of bone in the load-bearing area. In the need of defect repair, PMMA is also difficult to make a porous structure, which makes it difficult for the implant to obtain ideal tissue integration, so new methods are urgently needed to replace it.

[0005] At the same time, the internal fixation of metal materials such as titanium alloy (Titanium, Ti) and 316L stainless steel to fill bone defects has high mechanical strength, but it does not have biological activity, and it is difficult to compound with anti-infective drugs, and even the metal itself is often still intact. It may become a carrier for bacteria to persist, and it cannot be applied to the clinical repair of infected bone defects

However, the use of natural porous materials such as tantalum metal in combination with anti-infective drugs cannot be widely used in clinical practice due to the high price of tantalum metal and the difficulty in compounding with anti-infective drugs.

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