Degradable controllable bone tissue engineering scaffold based on 3D printing and preparation method thereof

A technology of 3D printing and porous scaffolds, applied in tissue regeneration, medical science, prostheses, etc., can solve problems such as difficult to prepare pores smaller than 100µm and control surface nanoscale topological structure, so as to promote bone repair and reconstruction, biological The effect of good compatibility and good bone repair effect

Inactive Publication Date: 2019-01-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Porous structures of 100-1000 µm can be effectively designed and prepared by 3D printing technology, but it is difficult to prepare pores smaller than 100 µm and control the surface nanoscale topology

Method used

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  • Degradable controllable bone tissue engineering scaffold based on 3D printing and preparation method thereof
  • Degradable controllable bone tissue engineering scaffold based on 3D printing and preparation method thereof
  • Degradable controllable bone tissue engineering scaffold based on 3D printing and preparation method thereof

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preparation example Construction

[0028] A method for preparing a 3D printed multi-level micro-nano structure controllable bioactive ceramic support, comprising the following steps:

[0029] 1. Prepare a bioactive ceramic scaffold with first-level macroscopic pores, and the specific preparation route is as follows:

[0030] (1) Mix calcium phosphate powder with bio-binder polyvinyl alcohol (PVB, Mn=70000-90000) and ethanol (Sigma) at a mass ratio of 3.6:32:32, and mix thoroughly to obtain calcium phosphate-based bioactive ceramics Print ink.

[0031] (2) The ceramic ink prepared above is used to prepare the target model by three-dimensional inkjet printing technology (3DP). During the printing process, the print head accumulates the target model layer by layer according to the set path, the selected print head diameter is 0.4mm, and the printing speed is 5-20mm / s. The printed model can be reversely reconstructed using 3D software based on the patient's bone defect data, and the internal porous structure of t...

Embodiment 1

[0039] (1) Configure calcium phosphate bioactive ceramic printing ink;

[0040] Thoroughly mix hydroxyapatite (HA) and tricalcium phosphate powder (TCP), wherein the mass ratio of hydroxyapatite (HA) to tricalcium phosphate (TCP) is 6:4, and the calcium phosphate powder and biological The binder polyvinyl alcohol (PVB, Mn=80000) and ethanol (Sigma) were fully mixed according to the mass ratio of 3.6:32:32 to prepare the calcium phosphate bioactive ceramic printing ink.

[0041] (2) Three-dimensional inkjet printing technology (3DP) is used to prepare a macroporous bioceramic body of the first level; the size of the first-level macroscopic macropores is designed by a three-dimensional design software. The nozzle diameter (d) is 200 μm, the slice thickness (h) is 160 μm for slice layering, and the printing speed is 300 mm / min for slurry extrusion 3D printing.

[0042] (3) Put the printed embryo body in step 2 into an oven to remove the solvent and sinter it into porcelain. The ...

Embodiment 2

[0046] Calcium phosphate with a mass ratio of hydroxyapatite (HA) to tricalcium phosphate (TCP) of 3:7 was selected as the printing material. According to the method steps of Example 1, firstly, the first-level macro-scale macropore design 3D printing is carried out, and then the dissolution and recrystallization is carried out to carry out the second-level micro-nano scale surface topology regulation. The rest of the parameter selection and preparation process are the same as in Example 1. The advantage is that this embodiment adjusts the composition ratio of the raw materials and increases the ratio of tricalcium phosphate, which is more conducive to the re-dissolution and recrystallization of the material. Finally, an orthogonal porous bioceramic with a macro-scale macropore of 300 μm and a porosity of 70% was obtained. At the same time, the bioceramic had a micro-nano-scale topology on the surface of the second-level three-dimensional flaky whiskers, and the length of the f...

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Abstract

The invention relates to the technical field of biomedical materials, which relates to a 3D printing material, in particular to a 3D printing multilayer micro-nano structure controllable porous bioactive ceramic material. The bioactive ceramic scaffold of the invention is a model with a certain macropore through parametric modeling design, and 3D printing technology is used to shape a certain ratio of calcium phosphate raw materials into the designed model. The porous calcium phosphate scaffolds were fabricated by sintering the calcium phosphate scaffolds, and then the micro-nano-structure ofthe scaffolds was changed by solution recrystallization. In this invention, by adjusting the ratio of hydroxyapatite (HA) to tricalcium phosphate (TCP) in the raw material, the primary macropore structure of the scaffold was designed, and the secondary micro-nano morphology and structure of the scaffold were controlled by controlling the environmental parameters of the solution recrystallization reaction medium, such as temperature, time, pH value of the medium and so on. The scaffolds for bone tissue engineering could be customized according to different patients.

Description

technical field [0001] The technical field of biomedical materials of the present invention relates to a 3D printing material, specifically a 3D printing multi-level micro-nano structure controllable porous bioactive ceramic material. Background technique [0002] Every year, the number of patients with hard tissue defects due to bone trauma, bone tissue inflammation, bone tumor resection, accidents, and population aging is increasing. In the repair of bone tissue lesions, allogeneic tissue repair has severe immune rejection, and the source of autologous tissue is limited. The use of artificial materials for hard tissue replacement and repair undoubtedly has important application value. Calcium phosphate (GaP) bioceramics has great market application prospects due to its excellent biocompatibility, non-toxicity, non-irritation, non-rejection, and good osteoconductivity and osteoinductivity. Hydroxyapatite (HA), tricalcium phosphate (TCP) and biphasic calcium phosphate (BC...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/56A61L27/50A61L27/12
CPCA61L27/12A61L27/50A61L27/56A61L27/58A61L2430/02
Inventor 周长春樊渝江张勃庆孙勇裴玄李慧勇王科锋蒋青张兴栋
Owner SICHUAN UNIV
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