Glucose non-enzymatic catalytic sensor and preparation method thereof

Abstract

The invention relates to a non-enzymatic catalytic sensor for glucose and a preparation method thereof. Meso-Tetrakis (4-(N-methylpyridyl)) porphyrin iron (III) molecule (abbreviated as FeTMPyP) self-assembles calixarene-modified gold nanoparticles into three-dimensional gold nanostructures, the system of which will be constructed onto a gold electrode modified with the same calixarene so that a glucose sensor composed of three-dimensional gold nano-particles is produced, the hydrogen peroxide and glucose is catalyzed by a double catalytic system under electrochemical conditions to achieve thesame measuring effect as a glucose sensor. The invention utilizes the self-assembly of the three-dimensional structure of the gold nanometer by the porphyrin, and greatly expands the application of the calixarene functionalized gold nanoparticle, so as to facilitate the greater application for the functionalized gold nanoparticles in the future production, human lives and researches. The invention also provides a more convenient method for the detection of glucose in disease surveillance and industrial production.

Description

technical field [0001] The invention relates to a glucose-mimetic enzyme sensor and a preparation method thereof, in particular to a non-enzyme-catalyzed glucose sensor constructed by three-dimensional gold nanometers and a preparation method thereof. Background technique [0002] The detection of glucose content has very important applications in many fields such as medical diagnosis, food industry, and biotechnology. The construction of electrochemical biosensors using the specific catalytic ability of glucose oxidase for glucose has been a hotspot of current research. However, due to the inherent instability of enzyme molecules, they are affected by various environmental factors, such as temperature, oxygen concentration, pH value, humidity, surfactants, organic reagents, etc., which limit the use of enzyme biosensors in the fermentation process and human blood. Applications in continuous testing. Therefore, we urgently need to prepare a non-enzymatic glucose sensor wit...

AI Technical Summary

Problems solved by technology

However, these new materials also show certain disadvantages, such as their oxidation selectivity is lower than that of enzyme electrode sensors, and in the actual sample detection, the coexisting molecules such as ascorbic acid and uric acid will interfere with the detection of glucose

And some non-enzymatic glucose sensors are also relatively expensive, prone to chloride ion poisoning, etc., these shortcomings greatly limit their application

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