Preparation method of L-selenocystine

A technology for selenocystine and dimethylcystine, which is applied in the field of preparation of L-selenocystine, can solve the problems of difficult separation and purification of substituted products, complicated processes, and tediousness.
CN109369482AActive Publication Date: 2019-02-22河南希百康健康产业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
河南希百康健康产业有限公司
Publication Date
2019-02-22

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Abstract

The invention provides a preparation method of L-selenocystine. The preparation method comprises the following steps: A) carrying out nucleophilic substitution reaction on sodium diselenide and N-acetyl-3-chloro-L-serine methyl ester to obtain N,N'-diacetyl-L-selenocystine dimethyl ester; B) hydrolyzing the N,N'-diacetyl-L-selenocystine dimethyl ester in a hydrochloric acid solution to obtain theL-selenocystine. The preparation method takes an N-acetyl-3-chloro-L-serine methyl ester chiral raw material as a substrate and sodium borohydride as a reducingagent, has the characteristics of easy-to-obtain and cheap raw materials, convenience for operation, moderate reaction conditions, single product, easiness for separation and high yield and the like and is suitable for industrial production. A test result proves that the specific rotatory power of the preparation method provided by the invention can reach that [alpha]D<20> is equal to -29.5 DEG (C 0.5, 0.1 MNaOH) and the highest yield of a product is 80.6 percent.
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Description

technical field

[0001] The invention belongs to the technical field of organic fine chemical synthesis, and in particular relates to a preparation method of L-selenocystine. Background technique

[0002] Selenium is an essential trace element for the human body and an important part of various enzymes in the human body. Once the human body is deficient in selenium, it will directly lead to cardiovascular and cerebrovascular diseases, hypertension, metabolic syndrome, gastrointestinal diseases, diabetes, asthma, Parkinson's The occurrence of more than 40 diseases such as liver disease, liver disease and cancer indirectly leads to the occurrence of more than 400 diseases. Therefore, the great effect of selenium on human health cannot be replaced by other substances. According to the data released by the World Health Organization, there are more than 40 countries and regions in the world that suffer from selenium deficiency in varying degrees. 72% of my country's regions are s...

Claims

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