Method for preparing tissue repair adhesion conductive hydrogel

A conductive hydrogel and tissue repair technology, applied in the direction of electrotherapy, conductive adhesives, electrodes, etc., can solve the problems of unchanged application, poor adhesion performance, and decreased electrical conductivity, and achieve good biocompatibility, good Effects of adhesion ability and high conductivity

Inactive Publication Date: 2019-03-12
SOUTHWEST JIAOTONG UNIV
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Usually, adding a certain conductive substance to the hydrogel can give the hydrogel good electrical conductivity; conductive hydrogel has a wide range of application prospects, such as electrical stimulation to promote wound healing, electrical sensors, capacitors, etc.; poly-3,4-ethylene Dioxythiophene is a commonly used high-molecular polymer with good electrical conductivity; but because it has a rigid structure and there are Π electron interactions between chains, it is easy to agglomerate in water; resulting in poly 3,4- The conductivity of ethylenedioxythiophene decreases; the traditional method is to improve the water dispersibility of poly3,4-ethylenedioxythiophene by doping polystyrene sulfonate to obtain a compound with good water dispersibility
[0004] Conductive hydrogels have good development prospects in tissue repair, but most of the currently used conductive hydrogels have poor or no adhesion properties; they are prone to fall off from the surface of tissues or objects during actual use. , has caused no change to the actual application; and the polystyrene sulfonate traditionally used to improve poly3,4-ethylenedioxythiophene has certain biological toxicity

Method used

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  • Method for preparing tissue repair adhesion conductive hydrogel
  • Method for preparing tissue repair adhesion conductive hydrogel

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preparation example Construction

[0025] A method for preparing an adhesive conductive hydrogel for tissue repair, comprising the following steps:

[0026] Step 1: Dissolve a certain amount of lignin in an alkaline solution, heat the oil bath to 85-95°C, add a certain amount of persulfate or sulfite solution, and react at 85-95°C for 2-3 hours. Obtain sulfonated lignin after natural cooling;

[0027] The alkaline solution is sodium hydroxide or potassium hydroxide, the persulfate is one of potassium persulfate, sodium persulfate and ammonium persulfate, and the sulfite is one of sodium sulfite, ammonium sulfite and potassium sulfite.

[0028] Step 2: add a certain amount of sulfonated lignin and conductive polymer obtained in step 1 into deionized water, acid solution or aqueous solution, add a certain amount of oxidant, and stir at high speed for 24 to 48 hours to obtain composite nanoparticle dispersion solution; the obtained composite nanoparticles were washed with deionized water, centrifuged, and repeate...

Embodiment 1

[0033] A method for preparing an adhesive conductive hydrogel for tissue repair, comprising the following steps:

[0034] A. Sulfonation modification of natural lignin

[0035] Add sodium hydroxide and lignin with a mass ratio of 2:5 to deionized water in sequence to obtain a lignin solution with a mass concentration of 10%; heat the oil bath to 90°C; then add ammonium persulfate 1.5 times the mass of lignin , Ammonium persulfate is configured into a solution with a concentration of 30%; react for 2 hours, and after natural cooling, the sulfonated lignin is formed.

[0036] B. Poly(3,4-ethylenedioxythiophene / sulfonated lignin nanoparticles)

[0037] Dissolving 3,4-ethylenedioxythiophene and the sulfonated lignin obtained in step A in deionized water at a mass ratio of 2:1 to obtain a mixed solution;

[0038] Ammonium persulfate of 1.5 times the mass of 3,4-ethylenedioxythiophene was added to the mixed solution, and the reaction was stirred at high speed for 48 hours to obtai...

Embodiment 2

[0048] A method for preparing an adhesive conductive hydrogel for tissue repair, comprising the following steps:

[0049] A. Sulfonation modification of natural lignin

[0050] Add sodium hydroxide and lignin with a mass ratio of 2:5 to deionized water in sequence to obtain a lignin solution with a mass concentration of 10%; heat the oil bath to 90°C; then add ammonium persulfate 1.5 times the mass of lignin , Ammonium persulfate is configured into a solution with a concentration of 30%; react for 2 hours, and after natural cooling, the sulfonated lignin is formed.

[0051] B. Poly(3,4-ethylenedioxythiophene / sulfonated lignin nanoparticles)

[0052] Adding 3,4-ethylenedioxythiophene and the sulfonated lignin obtained in step A to deionized water in a mass ratio of 2:1 to obtain a mixed solution;

[0053] Add iron sulfate twice the mass of 3,4-ethylenedioxythiophene to the mixed solution, and react with high-speed stirring for 48 hours to obtain blue-black poly-3,4-ethylenedi...

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Abstract

The invention discloses a method for preparing tissue repair adhesion conductive hydrogel. The method includes carrying out sulfonation modification on lignin to allow the lignin to obtain hydrophilicsulfonic acid groups; polymerizing oxidation 3,4-ethylene thiophene dioxide monomers and simultaneously preparing poly-3,4-ethylene thiophene dioxide / lignin sulfonate complexes; doping the complex particles in hydrogel to obtain the tissue repair adhesion conductive hydrogel. The method has the advantages that the lignin with large quantities of abundant phenolic hydroxy functional groups is doped in the hydrogel, mutual effects can be realized by the phenolic hydroxy functional groups and the surfaces of objects, and accordingly the tissue repair adhesion conductive hydrogel is excellent inadhesion performance; the dispersibility of poly-3,4-ethylene thiophene dioxide can be improved by the sulfonated lignin, accordingly, poly-3,4-ethylene thiophene dioxide polymer particles are small and can be uniformly dispersed in hydrogel matrixes, and the tissue repair adhesion conductive hydrogel is good in conductivity; the tissue repair adhesion conductive hydrogel is good in biocompatibility.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a method for preparing an adhesive conductive hydrogel for tissue repair. Background technique [0002] Hydrogel has high water content, good biocompatibility, porous structure and other conditions conducive to cell growth, and is an ideal material for tissue repair; hydrogel covering the surface of damaged tissue can create a closed microenvironment to avoid Damaged tissue is exposed to the external environment and causes infection; at the same time, its high water content can keep the surface of the tissue moist, and the porous bionic structure is conducive to inducing the proliferation and differentiation of cells in situ, thereby accelerating the healing of damaged tissue. [0003] Usually, adding certain conductive substances to the hydrogel can give the hydrogel good electrical conductivity; conductive hydrogel has a wide range of application prospects, such as electri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/56C08F222/38C08F122/38C08F220/06C08F2/48A61K50/00
CPCA61K9/0009C08F2/48C08F122/385C08F220/06C08F220/56C08F222/385
Inventor 鲁雄帅涛甘东林闫力维王笑
Owner SOUTHWEST JIAOTONG UNIV
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