The invention discloses a full-nutrient dietary composition suitable for the Crohn disease and a preparation method thereof. The full-nutrient dietary composition comprises the following components: glucose, hemsleya amabilis polysaccharide, a whey protein hydrolysate small molecule peptide, leucine, isoleucine, valine, glycine, histidine, milk fat, medium chain triglyceride, corn oil, n-3 unsaturated fatty acid, choline, taurine, hemsleya amabilis polyphenol, curcumin, vitamin A, vitamin D, vitamin E, vitamin C, potassium, magnesium, calcium, phosphorus, zinc, selenium, iron, glutamine, arginine, nicotinic acid, pantothenic acid, vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, iodine, vitamin K1 and biotin. According to the invention, the small molecule peptide is selected, so that the intestinal burden can be relieved, diarrhea can be relieved; and meanwhile, various antioxidant nutrients are added to synergistically take an antioxidant multiplication effect, so that the postoperative oxidative stress reaction is reduced, and the risk of postoperative infection and complications of a patient suffering from the Crohn disease is reduced.