A method for extracting flavonoid glycoside from lotus leaf and pharmaceutical preparation including flavonoid glycoside from lotus leaf
A technology of lotus leaf flavonoid glycosides and an extraction method, which is applied in the field of extraction and application of traditional Chinese medicine, can solve the problems of complicated and lengthy purification process, low product purity and high production cost, and achieves stable and controllable product quality, cost reduction and equipment saving. Effect
Active Publication Date: 2020-09-25
NANJING CHENXIANG MEDICAL RES
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Problems solved by technology
However, the existing methods for extracting flavonoid glycosides from lotus leaf, or the purification process are cumbersome and tedious, time-consuming and troublesome, the production cost is high, or the product purity is not high, or the yield is low, all unsatisfactory, and there is no large-scale production
Method used
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Embodiment 5
[0069] Embodiment 5 lotus leaf flavonoid glycoside sustained-release pellets
[0070] Preparation of Sustained and Controlled Release Pellets of Flavonoid Glycosides from Lotus Leaf
[0071] Preparation of Prescription 1 Normal Dissolution Pellets
[0072] Pill Heart Prescription 1
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[0074]
[0075] Coating Solution Prescription 1
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[0077] crafting process
[0078] Pretreatment Take starch, pregelatinized starch, sodium carboxymethyl starch (2.5g inside), and microcrystalline cellulose are mixed according to the principle of equal increase to form an auxiliary material mixture; take lotus leaf flavonoid glycosides, PVPK 12 Pass through a 120 mesh sieve and mix well. Use an appropriate amount of 75% ethanol to dissolve into a solution.
[0079] Flavonoid glucoside and PVPK 12 Add the 75% ethanol liquid into the auxiliary material mixture, mix while adding, after adding, knead repeatedly to make a soft material.
[0080] Extrusion and spheronizati...
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The invention provides an extraction method and purification method of flavonoid glycoside of lotus leaves, and a preparation containing the flavonoid glycoside of lotus leaves, and belongs to the technical field of the traditional Chinese medicine extraction. The method comprises the following steps: adding water at 60-80 DEG C in lotus leaf powder, stirring and extracting, separating extractingsolution from filter residues, extracting for three times, cooling filtrate to the room temperature, adjusting pH as 2-3, placing for 2h, performing cross-flow filtration to obtain refined filtrate; adjusting pH of the refined filtrate to 5-6.5, adsorbing, washing and eluting by adopting macroporous resin, collecting eluant with purity of the flavonoid glycoside of lotus leaves not less than 99%,and accomplishing the extraction and purification of the flavonoid glycoside of lotus leaves. The flavonoid glycoside of lotus leaves acquired through purification is quercetin-3-O-beta-Dglucuronide,the purity of the quercetin-3-O-beta-Dglucuronide is greater than 99.22%, the yield is high, and the cost is low. The extraction method provided by the invention is simple and fast, the extraction process can realize automation, intelligence, greening and digital quantization.
Description
technical field [0001] The invention belongs to the technical field of extraction and application of traditional Chinese medicines, and in particular relates to a method for extracting flavonoid glycosides from lotus leaf and pharmaceutical preparations including flavonoid glycosides from lotus leaves. Background technique [0002] The water lily plant lotus (Nelumbonuciferaei Gaertn) is planted in many places in China, and it is widely planted in Jiangsu, Zhejiang, Anhui and other provinces. It can be used as an ornamental, edible, and medicinal plant. Industries have applications. Lotus leaf contains more than 100 kinds of chemical components such as flavonoids, alkaloids, polyphenols, volatile oils, steroids, terpenes, fatty acids, fatty alcohols, proteins, tannins, etc. Flavonoids and alkaloids are the main pharmacological active ingredients . Flavonoids include monoglucuronide (quercetin-3-O-β-D-glucuronide, Q3GA), diglucuronide (quercetin-3-O-β-D-glucuronide acid gl...
Claims
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IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61P39/06A61P9/10A61P1/16A61P3/06A61P7/04A61P37/04
CPCA61K31/7048A61P1/16A61P3/06A61P7/04A61P9/10A61P37/04A61P39/06C07H1/08C07H17/07
Inventor 吴祖栋杨丽齐炼文邢宸邢为藩
Owner NANJING CHENXIANG MEDICAL RES