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Application of dl-3-n-butylphthalide to protection of intracerebral hippocampus gamma network vibration caused by acute alcoholism

A technology of alcoholism and butylphthalide, which is applied in the application field of butylphthalide in the protection of hippocampal gamma network oscillations in the brain caused by acute alcoholism. It can solve the problems of little research on the protective effect and related mechanisms, and achieve the purpose of inhibiting nerve cells. Effects of apoptosis, reduction of inhibition, reduction of damage

Inactive Publication Date: 2019-03-29
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, in my country, there are few studies on the protective effect of butylphthalide on the hippocampal γ network oscillation and related mechanisms in acute alcoholism. Deeper and deeper, it will provide more possibilities for the prevention and treatment of acute alcoholism with butylphthalide

Method used

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  • Application of dl-3-n-butylphthalide to protection of intracerebral hippocampus gamma network vibration caused by acute alcoholism
  • Application of dl-3-n-butylphthalide to protection of intracerebral hippocampus gamma network vibration caused by acute alcoholism
  • Application of dl-3-n-butylphthalide to protection of intracerebral hippocampus gamma network vibration caused by acute alcoholism

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Embodiment 1

[0030] 1. Preparation of main reagents

[0031] 1.1 Preparation of artificial cerebrospinal fluid (ACSF) Use a 500ml beaker, add Milli-Q water to 400ml, add 7.363g NaCl, 0.224g KCL, 0.235gMgSO4 , 0.150g NaH 2 PO 4 , 2.016g NaHCO 3 , 0.222g CaCl 2 , 1.8g Glucose, stirred with a magnetic stirrer to make it dissolve completely and then settled to 1000ml, sealed with plastic wrap, and mixed gas (95% O 2 +5%CO 2 ) after 30 minutes, the pH value is stable between 7.35-7.45, stored at room temperature, and used on the same day.

[0032] 1.2 Preparation of sliced ​​cerebrospinal fluid Use a 500ml beaker, add Milli-Q water to 350ml, add 38.475g Sucrose, 0.112g KCL, 0.361g MgSO in sequence 4 , 0.075g NaH 2 PO4, 1.008g NaHCO 3 , 0.028g CaCl 2 , 0.9gGlucose, stirred with a magnetic stirrer to make it dissolve completely, then set the volume to 500ml, seal with plastic wrap, take it out from the refrigerator at -80°C for 30min, and pass the mixed gas (95% O 2 +5%CO 2 ) After 30 m...

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Abstract

The invention discloses an application of dl-3-n-butylphthalide in protection of intracerebral hippocampus gamma network vibration caused by acute alcoholism. According to the application disclosed bythe invention, the inventor finds that after alcohol perfusion is adopted, the frequency and the energy spectrum mean value of hippocampus gamma network vibration of hippocampal slices of mice at different age groups can be obviously reduced compared with those before alcohol perfusion, and then after dl-3-n-butylphthalide perfusion is adopted, the frequency and the energy spectrum mean value ofhippocampus gamma network vibration of hippocampal slices of mice suffering from the acute alcoholism at different age groups are obviously raised compared with those before the dl-3-n-butylphthalideperfusion; the above situation illustrates that the dl-3-n-butylphthalide can protect the structure and the function of nerve cells under the action of alcohol, alleviate the damage degree of the alcohol to nerve functions, restrain apoptosis of nerve cells, and reduce the restraining effect of the alcohol on the gamma network vibration, so that increase of learning and memory ability and rise ofintelligence level of the mice suffering from the acute alcoholism can be realized; and the above situation further illustrates that the dl-3-n-butylphthalide can be used for preparing medicines capable of alleviating damage caused by the acute alcoholism to the nerve cells at the CA3 region of hippocampus, and relieving the damage of the acute alcoholism to learning and memory ability.

Description

technical field [0001] The present invention relates to a new application of butylphthalide, in particular to the application of butylphthalide in the protection of intracerebral hippocampal gamma network oscillation caused by acute alcoholism and the application in alleviating neuron damage caused by acute alcoholism. Background technique [0002] Butylphthalide (NBP) is a class of new chemical drugs with independent intellectual property rights successfully developed in my country. It is a synthetic racemate, and its L-form exists in celery seeds. Studies have found that NBP has a strong anti-cerebral ischemia effect, reduces the infarct size of regional cerebral ischemia, reduces cerebral edema, improves brain energy metabolism and microcirculation and blood flow in ischemic brain regions, and inhibits nerve cell apoptosis. , and has anti-thrombosis and anti-platelet aggregation effects, as well as improving energy metabolism after global cerebral ischemia and inhibiting ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P39/02A61P25/00
CPCA61P25/00A61P39/02A61K31/365
Inventor 杜爱林罗晓秋王克杰张越姚良雪黄亚迪杨宁宁曹雨鑫尹诗祎陈桂芳李慧敏李慧娜石丽莉刘思辰杨飞宏魏培韵尚怡研张瑞岭姜洪波
Owner XINXIANG MEDICAL UNIV
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