Application of dl-3-n-butylphthalide to protection of intracerebral hippocampus gamma network vibration caused by acute alcoholism

Abstract

The invention discloses an application of dl-3-n-butylphthalide in protection of intracerebral hippocampus gamma network vibration caused by acute alcoholism. According to the application disclosed bythe invention, the inventor finds that after alcohol perfusion is adopted, the frequency and the energy spectrum mean value of hippocampus gamma network vibration of hippocampal slices of mice at different age groups can be obviously reduced compared with those before alcohol perfusion, and then after dl-3-n-butylphthalide perfusion is adopted, the frequency and the energy spectrum mean value ofhippocampus gamma network vibration of hippocampal slices of mice suffering from the acute alcoholism at different age groups are obviously raised compared with those before the dl-3-n-butylphthalideperfusion; the above situation illustrates that the dl-3-n-butylphthalide can protect the structure and the function of nerve cells under the action of alcohol, alleviate the damage degree of the alcohol to nerve functions, restrain apoptosis of nerve cells, and reduce the restraining effect of the alcohol on the gamma network vibration, so that increase of learning and memory ability and rise ofintelligence level of the mice suffering from the acute alcoholism can be realized; and the above situation further illustrates that the dl-3-n-butylphthalide can be used for preparing medicines capable of alleviating damage caused by the acute alcoholism to the nerve cells at the CA3 region of hippocampus, and relieving the damage of the acute alcoholism to learning and memory ability.

Description

technical field [0001] The present invention relates to a new application of butylphthalide, in particular to the application of butylphthalide in the protection of intracerebral hippocampal gamma network oscillation caused by acute alcoholism and the application in alleviating neuron damage caused by acute alcoholism. Background technique [0002] Butylphthalide (NBP) is a class of new chemical drugs with independent intellectual property rights successfully developed in my country. It is a synthetic racemate, and its L-form exists in celery seeds. Studies have found that NBP has a strong anti-cerebral ischemia effect, reduces the infarct size of regional cerebral ischemia, reduces cerebral edema, improves brain energy metabolism and microcirculation and blood flow in ischemic brain regions, and inhibits nerve cell apoptosis. , and has anti-thrombosis and anti-platelet aggregation effects, as well as improving energy metabolism after global cerebral ischemia and inhibiting ...

AI Technical Summary

Problems solved by technology

[0006] At present, in my country, there are few studies on the protective effect of butylphthalide on the hippocampal γ network oscillation and related mechanisms in acute alcoholism. Deeper and deeper, it will provide more possibilities for the prevention and treatment of acute alcoholism with butylphthalide

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