Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of hydrogel dressing with high oxygen transmission rate and preparation method thereof

A technology of oxygen transmission rate and hydrogel, which is applied in the field of high oxygen transmission rate hydrogel dressing and its preparation, and can solve the problems of low oxygen transmission rate, low light transmittance, poor mechanical properties, etc.

Active Publication Date: 2021-07-13
JILIN UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to simultaneously adjust its compatibility with The proportion of hydrogel monomers, and finally trigger the polymerization of monomers to form gels under ultraviolet light, so as to solve the problems of low oxygen transmission rate, poor mechanical properties and low light transmittance of existing hydrogel dressings

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of hydrogel dressing with high oxygen transmission rate and preparation method thereof
  • A kind of hydrogel dressing with high oxygen transmission rate and preparation method thereof
  • A kind of hydrogel dressing with high oxygen transmission rate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of preparation preparation method of polysiloxane macromonomer crosslinking agent, it comprises the following steps:

[0031] Add 7.5g of KF-6001 into a 100mL branch bottle, insert a mechanical stirrer, coat the cock with vacuum ester, connect the branch to a vacuum line, and dry in a 55°C water bath at 300rmp for 2 hours. Balance the air pressure to normal pressure for 30±5min, weigh 1.165g IEM by differential method, inject it into the reactor with a syringe, use a 100μL micro-sampler to absorb 100μL of dibutyltin dilaurate catalyst and drop it into the reactor, and stir at room temperature for 16h . Dissolve the product in the reaction bottle with 35 mL of n-propanol, transfer it to the product bottle, suction filter with a 5 μm filter membrane, and remove the solvent by rotary evaporation to obtain a polysiloxane macromer crosslinking agent.

Embodiment 2

[0033] A preparation method of a high oxygen permeability hydrogel dressing, which comprises the following steps:

[0034] Measure the polysiloxane macromonomer cross-linking agent in the embodiment 1 of 37.5g, the hydroxyethyl methacrylate (HEMA) of 17.8g, the methacryloxypropyl group tri(trimethylsilyl) of 20.6g Oxyalkyl) silane (Tris), 1.0 g of Darocur 1173 was dissolved in 23.1 g of n-propanol by mass percentage, magnetically stirred for 20 minutes, and ultrasonically defoamed for 10 minutes to obtain a polymerization solution for use. Use a pipette gun to draw 5mL of the polymerization solution and drop it into a polytetrafluoroethylene mold with a 5*5*0.2cm inner groove. After the drop is full, cover the mold with a 6*6*0.2cm glass plate, and place the whole under ultraviolet light. Under light, polymerize for 40min. Open the glass plate, take off the polymerized solid gel from the mold, wash it with ethanol for 15 minutes, and place it in physiological saline to obtain...

Embodiment 3

[0036] Material in embodiment 2 is carried out biocompatibility evaluation, cell used is mouse embryonic fibroblast (3T3), prepares cell suspension, inoculates in the 24-well plate that is placed dressing material in embodiment 2; Control group is Cells were seeded in 96-well plates without the dressing material in Example 2. 10000 cells per well. Place them in an incubator with 5% carbon dioxide at 37° C., replace with fresh 10% fetal bovine serum medium every 24 hours, and conduct a CCK-8 cell proliferation test. Detect the OD value at 450nm wavelength, the higher the OD value, the more the number of cells.

[0037] The polysiloxane macromer crosslinking agent synthesized by the present invention and the hydrogel dressing with high oxygen transmission rate have been characterized in detail, and the specific characterization methods are as follows:

[0038] Infrared Spectroscopy Analysis

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
tensile stressaaaaaaaaaa
elongation at breakaaaaaaaaaa
Login to View More

Abstract

A high oxygen permeability hydrogel dressing and a preparation method thereof belong to the technical field of medical dressings. The present invention simultaneously regulates its interaction with hydraulic coagulation by introducing a high oxygen transmission rate, high mechanical performance silicone-containing vinyl monomer (which acts as a crosslinker and compatibilizer in the gel network) into the gel network. The ratio of the glue monomers, and finally trigger the polymerization of the monomers to form a gel under ultraviolet light, thereby solving the problems of low oxygen transmission rate, poor mechanical properties, and low light transmittance of the existing hydrogel dressings. The experimental results show that the inside of the dressing is a porous network structure, the swelling rate reaches 54.6%, and the oxygen transmission rate reaches 442.12OTR (mL / m 2 .day), the elongation at break reaches 400.1%, the tensile stress reaches 1.2704Mpa, and has good biocompatibility with mouse embryonic fibroblasts.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, in particular to a high oxygen permeability hydrogel dressing and a preparation method thereof. Background technique [0002] With the improvement of medical conditions and the enhancement of patients' health awareness, traditional wound dressings are more and more used in practical applications because of their shortcomings such as easy adhesion to the wound surface, easy secondary injury when replaced, and inability to block bacteria. Dressings substituted. With the continuous deepening of research on the mechanism of wound healing, it has been found that a moist wound environment can promote the migration of wound edge cells and accelerate wound healing. Therefore, moist dressings that are more in line with the theory of "moist healing" have developed rapidly. As the most widely studied and applied moist dressing, hydrogel dressing has many advantages, such as promoting wound heali...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/20A61L15/42
CPCA61L15/20A61L15/26A61L15/42C08L83/04
Inventor 汤钧丁一黄婷婷尧袁青
Owner JILIN UNIV