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A preparation method of fully degradable conductive hydrogel for tissue repair

A conductive hydrogel, tissue repair technology, applied in electrotherapy, conductive adhesives, electrodes, etc., can solve the problems of affecting activity, small particle size, poor stability of nano-iron materials, etc., to avoid toxicity and prevent rapid oxidation. Effect

Active Publication Date: 2021-06-25
SOUTHWEST JIAOTONG UNIV
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Problems solved by technology

[0004] Because nano-zero-valent iron has the function of fully degrading and conducting electricity, it is selected as a nanomaterial doped with hydrogel for tissue repair. In practical applications, there are still some problems to be solved in nano-zero-valent iron materials: nano-iron due to its high activity Moreover, the particle size is small, and it is easy to agglomerate to form micron or millimeter-sized particles to affect the activity; nano-iron materials have poor stability, are easy to oxidize or even spontaneously ignite in the environment, and require harsh operating conditions; these factors pose severe challenges to the preparation and use of nano-iron materials. Therefore, traditional conductive repair materials are often not biodegradable, and the dispersion and stability of nano-zero-valent iron also limit its application.

Method used

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preparation example Construction

[0024] A method for preparing a fully degradable conductive hydrogel for tissue repair, comprising the following steps:

[0025] Step 1: After adding 5% to 30% dopamine by weight of iron ions to 2 mg to 10 mg / ml iron ion solution to disperse, prepare dopamine dispersed nano zero-valent iron particles by liquid phase reduction method;

[0026] The specific process is as follows:

[0027] S1: Add a certain volume of 2 mg to 50 mg / ml FeSO 4 ·7H 2 O solution was added to a 500ml three-necked flask; 5% to 30% dopamine was added to the iron ion weight to form a mixed solution;

[0028] S2: Introduce high-purity nitrogen gas into the mixed solution in step S1 for 30 minutes to remove oxygen in the system; and continue to infuse nitrogen gas into the system to maintain an oxygen-free environment during the entire synthesis process; then stir for 10 minutes to make it fully mixed uniform;

[0029] S3: Turn on the electric stirrer, and at the same time, add the prepared reducing age...

Embodiment 1

[0033] Step 1: At room temperature, dissolve 100 ml of 30 mg / ml FeSO 4 ·7H 2 O solution was added to a 500ml three-necked flask; 0.03 g of dopamine was added to it to form a mixed solution; high-purity nitrogen gas was passed into the mixed solution for 30 min to remove oxygen in the system; and nitrogen gas was continuously fed into the system during the entire synthesis process to maintain Oxygen-free environment; then stir for 10 min to make it fully mixed; turn on the electric stirrer, and at the same time, prepare 100 ml containing 0.29 g NaBH 4 The aqueous solution was added dropwise from the constant pressure funnel into the three-necked flask; the dropping rate was controlled at 2 drops per second; reacted at 20°C for 60 minutes to form black dopamine-dispersed nano-zero-valent iron particles; after the reaction, magnetic separation was used to Nanometer iron particles were separated by the method, and then washed three times with deoxygenated deionized water, each ti...

Embodiment 2

[0037] Step 1: At room temperature, dissolve 200 ml of 20 mg / ml FeSO 4 ·7H 2 O solution was added to a 500 ml three-necked flask; 0.1 g of dopamine was added to it to form a mixed solution; high-purity nitrogen gas was passed into the mixed solution for 30 min to remove the oxygen in the system; and nitrogen gas was continuously passed into the system throughout the synthesis process Maintain an anaerobic environment; then stir for 10 min to make it fully mixed; turn on the electric stirrer, and at the same time, prepare 100 ml containing 0.29 g NaBH 4 The aqueous solution was added dropwise from the constant pressure funnel into the three-necked flask; the drop rate was controlled at 2 drops per second; reacted at 20°C for 20 min to form black dopamine-dispersed nano-zero-valent iron particles; after the reaction, magnetic separation was used to Nanometer iron particles were separated by the method, and then washed three times with deoxygenated deionized water, each time wit...

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Abstract

The invention discloses a preparation method of a fully degradable conductive hydrogel used for tissue repair, which belongs to the technical field of biomaterials. The present invention first prepares dopamine-dispersed nano-zero-valent iron by liquid-phase reduction method, and then adds nano-zero-valent iron to carbonyl-containing natural biomacromolecule solution and chitosan solution to mix evenly, and obtains it through Schiff base reaction for tissue repair. Fully degradable conductive hydrogels. The fully degradable conductive hydrogel matrix materials prepared by the present invention are all natural polymers, and the polymerized hydrogel through the Schiff base reaction also avoids the toxicity of traditional crosslinking agents to organisms. The required elements can also be excreted from the body, so it has the advantage of complete biodegradation; and can affect the adhesion, migration, proliferation, and DNA synthesis of various cells through the action of the electric field, and promote the healing of damaged tissues to achieve the goal of tissue repair. Purpose.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a method for preparing a fully degradable conductive hydrogel used for tissue repair. Background technique [0002] The self-repair ability of biological tissue is limited after damage, which makes the treatment of tissue damage a major medical problem; electrical stimulation has an important regulatory effect on cell behavior, and can affect the adhesion, migration, proliferation, DNA synthesis, protein Secretion and other physiological activities; by applying certain electrical stimulation to the human body, it can promote the healing of various damaged tissues, including the regeneration and repair of blood vessels, tendons, skin, bones, nerves, etc. [0003] At present, the conductive polymer materials commonly used in the field of biomedical engineering include polyaniline, polypyrrole and their derivatives; polyaniline and polypyrrole have great limitations in the appl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L5/08C08L5/04C08L71/02C08K9/10C08K9/04C08K3/08A61K50/00
CPCA61K9/0009C08J3/075C08J2305/04C08J2305/08C08J2371/02C08J2405/04C08J2405/08C08K9/04C08K9/10C08K2003/0856C08K2201/011
Inventor 鲁雄倪锐程闫力维
Owner SOUTHWEST JIAOTONG UNIV
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