Magnesium-silver-copper coating for medical implant material and preparation method of magnesium-silver-copper coating

An implant material, copper coating technology, applied in joint replacement and human tissue defect filling materials and implant materials antibacterial, dental implants, medical materials fields, can solve the problem of poor tissue compatibility of implant materials, Infection and other problems, to achieve the effect of promoting wound healing, increasing possibility, and good biocompatibility

Active Publication Date: 2019-04-19
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the tissue combination and infection problems of implant materials, the present invention provides a magnesium-silver-copper coating for medical implant materials and a preparation method thereof, which adopts multi-arc ion plating evaporation technology, and is coated on titanium and titanium alloys, A magnesium-silver-copper coating is prepared on the surface of solid and porous structure substrates made of stainless steel and polymer materials to solve the problems of poor histocompatibility and infection of existing implant materials. The coating obtained by this method has excellent biophase capacitive, and has the function of sterilization

Method used

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  • Magnesium-silver-copper coating for medical implant material and preparation method of magnesium-silver-copper coating

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Experimental program
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Effect test

Embodiment 1

[0027] Put the titanium alloy (Ti-6Al-4V) original sheet into the substrate 5 position in the deposition chamber 1, place the magnesium-silver-copper alloy target at the target 4 position, the Ag content in the magnesium-silver-copper alloy target is 1%, and the Cu content 0.1%, the balance of Mg. Ultimate vacuum (10 -5 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the bias voltage to 50V, the arc current to 30A, the duty cycle to 20%, and the working air pressure to 1×10 -2 Pa, the deposition time is 30 min, and the thickness of the deposited metal magnesium-silver-copper layer is 0.5 μm. In order to determine the effect of the coating on promoting osteogenesis, an alkaline phosphatase (ALP) experiment was carried out. After culturing for 1 day, 4 days and 7 days, the color of the coating group was darker than that of the matrix group, indicating the activity of alkaline phosphatase in the coating group. ...

Embodiment 2

[0029] Put the porous titanium alloy (Ti-6Al-4V) original sheet into the substrate 5 position in the furnace body 1 of the deposition chamber, place the magnesium-silver-copper alloy target at the target 4 position, and the Ag content in the magnesium-silver-copper alloy target is 2% , Cu content is 0.2%, Mg balance. Ultimate vacuum (10 - 5 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the bias voltage to 55V, the arc current to 40A, the duty cycle to 30%, and the working air pressure to 1×10 -2 Pa, the deposition time is 1 h, and the thickness of the deposited metal magnesium-silver-copper layer is 1 μm. Since the substrate is directly placed on the surface of the substrate holder, the bottom of the substrate in contact with the substrate holder cannot deposit the coating. The substrate can be turned over, the bottom is turned up, and the coating is completely covered on the substrate surface. Metal wir...

Embodiment 3

[0031]Put the planar pure titanium substrate into the substrate 5 position in the furnace body 1 of the deposition chamber, place the magnesium-silver-copper alloy target at the target 4 position, the Ag content in the magnesium-silver-copper alloy target is 3%, the Cu content is 0.8%, and the Mg margin. Ultimate vacuum (10 -5 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the bias voltage to 60V, the arc current to 55A, the duty cycle to 40%, and the working air pressure to 1×10 -1 Pa, the deposition time is 1 h, and the thickness of the deposited metal magnesium-silver-copper layer is 3 μm. After X-ray diffraction analysis and scanning electron microscope energy spectrum analysis, it is determined that the coating is a magnesium-silver-copper coating. Due to the low content of silver and copper, the X-ray spectrum can only show the diffraction information of metal magnesium.

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Abstract

The invention provides a magnesium-silver-copper coating for a medical implant material and a preparation method of the magnesium-silver-copper coating in order to solve the problems of synosteosis and infection of an the implant material. The multi-arc ion plating technology is adopted, the metal magnesium-silver-copper coating is prepared on an entity or a porous structure base body made from titanium, titanium alloy, stainless steel and a high polymer material, and the thickness of the coating ranges from 0.1 micrometer to 200 micrometers; and the mass percent of silver in the coating is larger than 0% and smaller than or equal to 10%, and the mass percent of copper is larger than 0% and smaller than or equal to 2%. The permanent implant material with the coating is suitable for the mechanical performance requirements of multiple implanting positions, and has excellent biocompatibility and a sterilizing function.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to dental implants, joint replacements and filling materials for human tissue defects and the antibacterial technical field of implant materials; specifically, the magnesium-silver-copper coating material coated on the surface of implants and its preparation method. Background technique [0002] Implants such as artificial joints only have a lifespan of 10-15 years due to adverse cell reactions caused by implant loosening and abrasion, which cannot meet the long-term use requirements. Meanwhile, infection remains one of the disastrous postoperative complications of orthopedic implants. Metallic foreign bodies implanted in the body are risk factors for such infections, and a series of in vivo reactions, including the weakening of macrophage function and the passivation of the local immune system, create favorable conditions for the proliferation of pathogens. In addition, the prote...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C14/16C23C14/20C23C14/32A61L27/30A61L27/54A61L27/58
CPCA61L27/306A61L27/54A61L27/58A61L2300/102A61L2300/104A61L2300/404A61L2300/412A61L2420/02C23C14/16C23C14/20C23C14/325
Inventor 于晓明谭丽丽杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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