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Carbon nanotube modified gelatin hydrogel and its preparation method and application

A carbon nanotube modification and carbon nanotube array technology, which is used in prosthesis, medical science, etc., can solve the problems of unsatisfactory mechanical properties of gelatin hydrogel, difficult uniform dispersion of carbon nanotubes, weak interaction, etc.

Active Publication Date: 2021-06-15
SHENZHEN XIWAN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the agglomerated nature of carbon nanotubes, it is difficult to disperse carbon nanotubes uniformly
At the same time, in the traditional technology, the interaction between carbon nanotubes and hydrogel is weak, resulting in the mechanical properties of the obtained carbon nanotube-modified gelatin hydrogel still not meeting the needs.

Method used

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  • Carbon nanotube modified gelatin hydrogel and its preparation method and application
  • Carbon nanotube modified gelatin hydrogel and its preparation method and application
  • Carbon nanotube modified gelatin hydrogel and its preparation method and application

Examples

Experimental program
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preparation example Construction

[0041] An embodiment of the carbon nanotube modified gelatin hydrogel, including the steps of:

[0042] S110: The methacrylate monomer is polymerized to obtain a structural formula. Methyl methacrylate polymer.

[0043] Where N is 1 ~ 11, r = C m Hide 2m+1 , M is 1 ~ 4. Specifically, the polymerization of the methacrylate polymer is 2 to 12, the molecular weight is 200 to 1200, and the polydispersity index is 1.10 to 1.20.

[0044] Specifically, the step of obtaining a methacrylate monomer is polymerized to give the step of obtaining a methacrylate polymer comprising:

[0045] S111: The methacrylate monomer, catalyst, initiator, and solvent are added to the reaction vessel and sealed.

[0046] Specifically, the methacrylate monomer is selected from the group consisting of methyl methacrylate, ethyl methacrylate, methyl methacrylate and methacrylate n-butyl methacrylate. The catalyst is a chelate of divalent cobalt, and the mass ratio of the catalyst to the monomer is 4.0 to 4.2:1...

Embodiment 1

[0093](1) 8 mg of tetramethoxyporphyl porphyrin cobalt, 190 mg of methacrylate monomer, 4 mg of azo diisobutyronitrile and 1.48 ml of chloroform, and then reflecting treatment, and reactive The container is sealed. The sealed reaction vessel was immersed in a constant temperature water bath in a constant temperature water bath for 1 h. After the reaction, ethyl acetone was added to precipitate the tetramethoxycetone, and then evaporated, and then evaporated, and the methacrylate polymer was obtained. The structural formula of the n-butyl ester polymer of the methacrylate is as follows:

[0094]

[0095] (2) A cobalt-nickel alloy catalyst layer is deposited on the first substrate, and the first substrate is placed in a chemical vapor deposition reaction furnace. Turn nitrogen, warmed to 550 ° C. Then, 25% ethylene, 5% hydrogen, and 70% nitrogen, reacted for 2 min to obtain a carbon nanotube array. A second substrate was taken, and a methacrylate polymer film having a thickness of...

Embodiment 2

[0099] (1) 8 mg of tetramethoxytinyl porphyrin cobalt, 190 mg of methacrylate monomer, 4 mg of azo diisobutyronitrile and 1.30 ml of chloroform, and the reaction vessel was subsequently processed. Perform a seal. The sealed reaction vessel was immersed in a constant temperature water bath in a constant temperature water bath for 1 h. After the end of the reaction, ethyl acetone was added to precipitate tetramethoxycetone, and then evaporated after filtration, and the methyl methacrylate polymer was obtained. The structural formula of methyl methacrylate polymer is as follows:

[0100]

[0101] (2) A cobalt-nickel alloy catalyst layer is deposited on the first substrate, and the first substrate is placed in a chemical vapor deposition reaction furnace. Hydrogen is entered, warmed to 630 ° C. Then, 25% ethylene, 5% hydrogen, and 70% nitrogen at 2 l / min, and the carbon nanotube array was obtained. A second substrate was taken and a methacrylate polymer film having a thickness of ...

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Abstract

The invention relates to a gelatin hydrogel modified by carbon nanotubes, a preparation method and application thereof. The preparation method of the gelatin hydrogel modified by the above-mentioned carbon nanotubes comprises: homopolymerizing the methacrylate monomer to obtain a methacrylate polymer; combining the carbon nanotube array with the methacrylate polymer grafting reaction to obtain a modified carbon nanotube array; reacting the modified carbon nanotube array with gelatin to obtain a carbon nanotube-modified gelatin prepolymer; and, cross-transferring the carbon nanotube-modified gelatin prepolymer Linked to get carbon nanotube-modified gelatin hydrogel. The carbon nanotubes used in the above-mentioned carbon nanotube-modified gelatin hydrogel are modified by methacrylate polymers, are easy to disperse, and can be covalently bonded and cross-linked with gelatin, resulting in better mechanical properties and Carbon nanotube-modified gelatin hydrogels with less impact on porosity.

Description

Technical field [0001] The present invention relates to the field of hydrogel, and in particular, to a gelatin hydrogel modified, a carbon nanotubes, and a preparation method thereof, and a preparation method thereof. Background technique [0002] Hydrogel can be used as a three-dimensional biopsy-proof matrix bracket due to its porous structure, high water content and controllable biodegradability, providing mechanical support for cell growth and tissue. [0003] Typically, hydrogels need to have sufficient mechanical strength as a three-dimensional biomass matrix stent to match the tissue to which the tissue to be simulated, such as brain, muscle or bone, at which time the mechanical intensity can be used by the density, crosslink density or molecular weight. control. However, although high cross-linking three-dimensional hydrogel has higher hardness, it hinders the proliferation, migration and morphology of cells. Although the prepolymer concentration of high polymer concentra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08L89/00C08K9/08C08K3/04A61L27/16A61L27/22A61L27/52A61L27/56
Inventor 邓飞
Owner SHENZHEN XIWAN TECH CO LTD