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Polyethyleneimine-based iodine-loading antibacterial cellulose material and preparation method and application thereof

A technology based on polyethyleneimine and polyethyleneimine, which is applied in the direction of antibacterial drugs, pharmaceutical formulations, active ingredients of iodine compounds, etc., and can solve the problem of uneven sterilization level and side effects, lack of bactericidal activity, and unstable stability Ideal and other issues, to achieve the effect of excellent antibacterial effect, long-lasting antibacterial performance, and low equipment requirements

Active Publication Date: 2019-05-21
SOUTHWEST JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These iodophors basically exist in the form of liquid, paste or amorphous powder, the stability is not ideal, and the bactericidal level and toxic and side effects are also uneven.
In addition, the surfactants used in these products such as polyethylene glycol, nonylphenol polyoxyethylene ether, polyalcohol ether, polyvinyl alcohol, alkyl sulfonate, quaternary ammonium salt, etc. act as carriers and auxiliary agents in povidone iodine. The role of soluble, often lead to a considerable part of the "iodine existence form" does not have bactericidal activity and wasted in vain, but also leave yellow stains on the skin and even burn the skin

Method used

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  • Polyethyleneimine-based iodine-loading antibacterial cellulose material and preparation method and application thereof
  • Polyethyleneimine-based iodine-loading antibacterial cellulose material and preparation method and application thereof
  • Polyethyleneimine-based iodine-loading antibacterial cellulose material and preparation method and application thereof

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preparation example Construction

[0025] A preparation method of polyethyleneimine-based iodine-loaded antibacterial cellulose material, comprising the following steps:

[0026] Step 1: oxidizing the cellulose material in an aqueous solution containing an oxidizing agent, and washing to obtain the oxidized cellulose material after the oxidation is completed;

[0027] Cellulosic materials are natural cellulosic materials, regenerated cellulosic materials or mixtures thereof; cellulosic materials are in the form of monofilaments, multifilaments, braids, films, papers, blocks and hydrogels; the crystalline structure of cellulose used It is cellulose I, II, III and IV crystal forms or mixtures thereof.

[0028] The oxidizing agent is one of sodium periodate, potassium periodate and hydrogen peroxide; the amount of aldehyde groups on the oxidized cellulose material obtained after oxidation treatment is 50-500 μmol / g, preferably 100-300 μmol / g.

[0029] Step 2: immerse the oxidized cellulose material obtained in st...

Embodiment 1

[0034] Prepare polyethyleneimine-based iodine-loaded antibacterial cellulose material according to the following steps:

[0035] Step 1: Put 2g of regenerated cellulose gel film into a sodium periodate solution with a concentration of 1g / L and pH=5, oxidize it at 25°C for 6h, and then wash it with water to obtain a dialdehyde cellulose gel film ;

[0036] Step 2: Immerse the dialdehyde cellulose gel film obtained in step 1 in a PEI solution with a concentration of 0.05% and pH=10, carry out grafting reaction at room temperature, wash with water after 2 hours, and obtain polyethyleneimine after drying Grafted cellulose film;

[0037] Step 3: Place the polyethyleneimine grafted cellulose film obtained in step 2 in an iodine-potassium iodide solution with a pH of 6 and a concentration of 0.5%, treat it at room temperature for 1 hour, and dry it to obtain polyethyleneimine-based iodine-loaded antibacterial Cellulose film.

[0038] The iodine content in the polyethyleneimine-bas...

Embodiment 2

[0043] Prepare polyethyleneimine-based iodine-loaded antibacterial cellulose material according to the following steps:

[0044] Step 1: Put 2g of regenerated cellulose gel film into a sodium periodate solution with a concentration of 4g / L and pH=5, oxidize it at 25°C for 4 hours, and then wash it with water to obtain a dialdehyde cellulose gel film ;

[0045]Step 2: Immerse the dialdehyde cellulose gel film obtained in step 1 in a PEI solution with a concentration of 0.05% and pH=9, carry out grafting reaction at room temperature, wash with water after 2 hours, and obtain polyethyleneimine after drying Grafted cellulose film;

[0046] Step 3: The polyethyleneimine grafted cellulose membrane obtained in step 2 is placed in an iodine-potassium iodide solution with a concentration of 0.5% at pH=6, treated at 25°C for 1 hour, and dried to obtain polyethyleneimine-based iodine-loaded antibacterial Cellulose film.

[0047] The iodine content in the polyethyleneimine-based iodine...

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Abstract

The invention discloses a polyethyleneimine-based iodine-loading antibacterial cellulose material and a preparation method and application thereof. The preparation method includes the following stepsthat 1, a cellulose material is placed into an aqueous solution containing an oxidizing agent and oxidized, washing is conducted after the oxidation is completed, and an oxidized cellulose material isobtained; 2, the oxidized cellulose material obtained in the step 1 is immersed into a polyethyleneimine aqueous solution with the mass concentration of 0.01% to 5%, and after complete reacting, washing and drying are conducted to obtain a polyethyleneimine-grafted cellulose material; 3, the polyethyleneimine-grafted cellulosic material obtained in the step 2 is immersed into an iodine-iodide aqueous solution with the mass concentration of 0.1% to 5%, the mixture completely reacts and is aired, and the required polyethyleneimine-based iodine-loading antibacterial cellulose material is obtained, wherein the mass ratio of iodine to iodide in the iodine-iodide is 1:1 to 1:2. The preparation method is simple, the reaction condition is mild, and the obtained iodine-loading material is solid, has uniform iodine distribution, long-lasting antibacterial properties and an excellent antibacterial effect, and is convenient to carry and free of stained yellow.

Description

technical field [0001] The invention relates to the field of preparation of antibacterial materials, in particular to a polyethyleneimine-based iodine-loaded antibacterial cellulose material, a preparation method and an application. Background technique [0002] In recent years, a variety of bacterial diseases caused by microorganisms have brought great harm and panic to human beings; at the same time, the abuse of a large number of broad-spectrum antibiotics has led to the emergence of a large number of drug-resistant strains and mutant strains, so it has high-efficiency and broad-spectrum antibiotics Antibacterial agents need to be developed and applied urgently. Among many antibacterial agents, iodine is recognized as the safest and most reliable fungicide in the world. It has low tissue toxicity, strong killing ability to bacteria, fungi, viruses, spores, etc., and does not produce drug resistance; Sublimation, poor stability, almost insoluble in water, so its applicati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18A61K9/70A61K47/38A61K47/34A61P31/04
Inventor 张胜利凯橙橙刘伯芳张思略周祚万韦炜胡代燕
Owner SOUTHWEST JIAOTONG UNIV
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