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Application of trametes extract in preparing preparation for treating and/ or preventing intestinal flora disorder and related diseases

A technology of intestinal flora imbalance and extract, which is applied in the direction of metabolic diseases, allergic diseases, nervous system diseases, etc., can solve the problems of functional scope and marketing confusion, unclear quality control indicators of functional factors, and insufficient functions. , to achieve the effect of improving various physiological and pathological indicators related to immunity, contributing to the diversification of flora, and obvious therapeutic and/or preventive effects

Inactive Publication Date: 2019-05-21
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the improvement of the health quality of consumers, there is an even greater demand for refined health products. However, most of the existing edible and medicinal fungus health products have a confusing range of functions and market promotion. Functional factors and quality control indicators are not clear, and the functions are not significant enough. Medicinalization, therefore, there is an urgent need for more definite functional factors (active sites), a quality control system with medicinal effects and precision

Method used

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  • Application of trametes extract in preparing preparation for treating and/ or preventing intestinal flora disorder and related diseases
  • Application of trametes extract in preparing preparation for treating and/ or preventing intestinal flora disorder and related diseases
  • Application of trametes extract in preparing preparation for treating and/ or preventing intestinal flora disorder and related diseases

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preparation example Construction

[0050] In the fifth aspect of the present invention, there is provided a preparation method of Huaier extract, comprising: after pulverizing the fruit body of Huaier, sequentially extracting with alcohol, water, and NaOH alkaline water to obtain extraction solutions respectively, and then separately Concentrating and freeze-drying to obtain Huaier alcohol extract, Huaier water extract and Huaier alkine extract.

[0051] Preferably, a preparation method of Huaier extract comprises: after pulverizing Huaier fruit bodies, sequentially extracting with 95% ethanol, water, and 1%-2% NaOH alkaline water to obtain extraction solutions respectively, and then separately After concentrating and freeze-drying, Huaier alcohol extract, Huaier water extract and Huaier alkine extract are obtained.

[0052] Preferably, a preparation method of Huaier extract comprises: after pulverizing Huaier fruit bodies, extracting with ethanol reflux to obtain the first filter residue and alcohol extraction...

Embodiment 1

[0066] Embodiment 1: the preparation of Huaier extract, the steps are as follows:

[0067] (1) Pulverize the Huaier fruiting body, use ethanol with a solid-liquid ratio of 1:8-1:15, reflux and extract for 2-4 hours, filter with suction, obtain the filtrate, concentrate under reduced pressure to obtain a thick paste with an appropriate concentration, thick paste Freeze overnight at -80°C and dry in a freeze dryer to obtain Huaier alcohol extract.

[0068] (2) Take the above-mentioned filter residue after alcohol extraction, use water with a material-to-liquid ratio of 1:8-1:15, reflux extraction for 1-3 hours, and suction filter to obtain the filtrate, concentrate under reduced pressure to obtain a thick paste of appropriate concentration, The thick paste was frozen overnight at -80°C, and dried in a freeze dryer to obtain Huaier water extract.

[0069] (3) Take the above-mentioned filter residue extracted by alcohol and water, use 2% NaOH aqueous solution with a material-to-l...

Embodiment 2

[0073] Example 2: Improvement effect of Huaier extract on indicators related to intestinal flora imbalance in mice induced by high-fat diet

[0074] 1. Reagents:

[0075] Total cholesterol (T-CHO) test kit: Nanjing Jiancheng Institute of Bioengineering.

[0076] Triglyceride (TG) test kit: Nanjing Jiancheng Institute of Bioengineering.

[0077] Low-density lipoprotein cholesterol (LDL-C) test kit: Nanjing Jiancheng Bioengineering Institute.

[0078] High-density lipoprotein cholesterol (HDL-C) test kit: Nanjing Jiancheng Bioengineering Institute.

[0079] Thirty female C57 mice, SPF grade, weighing 12-14 g, and 28-30 days old, were purchased from Guangdong Medical Experimental Animal Center with license number SCXK (Guangdong) 2013-0002.

[0080]Rats and mice maintained feed: Guangdong Medical Experimental Animal Center, license number SCXK (Guangdong) 2013-0002.

[0081] The high-fat and high-cholesterol feed formula is shown in Table 2.

[0082] Table 2 Main components ...

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Abstract

The invention relates to an application of an edible fungus extract in preparing a preparation for treating and / or preventing intestinal flora disorder and related diseases, in particular to an application of a trametes extract in preparing a preparation for treating and / or preventing intestinal flora disorder and related diseases. The preparation method is simple and feasible, and low in operation cost; and an extraction solvent in the preparation method can be recycled, so that the residual risk of an organic reagent is avoided, and the natural quality of the trametes extract is ensured and the method is environment-friendly. The raw materials are completely extracted, the raw materials are fully utilized, and the utilization rate of the raw materials is high. The trametes extract notonly can obviously contribute to recovery of dominant flora structure in an intestinal tract and diversity of a flora, but also has obvious treatment and / or prevention effects on diseases related tointestinal flora structure, can be used in various fields such as medicines, health care products and the like, and has great economic and social values.

Description

technical field [0001] The present invention relates to the use of an edible fungus extract in the preparation of preparations for the treatment and / or prevention of intestinal flora disorders and related diseases, in particular to the use of Huaier extracts in the preparation of preparations for the treatment and / or prevention of intestinal flora disorders and related diseases. Background technique [0002] In recent years, studies on gut microbiota have been emerging, and the role of gut microbiota in human health has attracted more and more attention. Gut flora is the sum of all microorganisms in the human intestinal tract. There are many types (including bacteria, fungi and viruses), and the number is even more amazing. It is estimated that in a normal adult, the total weight of intestinal bacteria can reach 1-1.5kg. They can affect body weight, digestion and absorption capacity, and resist the risk of infection and autoimmune diseases; in addition, they are also assoc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61P1/00A61P37/04A61P3/06A61P3/04A61P31/04A61P29/00A61P37/08A61P25/00A61P35/00A23L33/105
Inventor 陈地灵唐晓萃郭殷锐吴清平谢意珍帅欧杨柏华
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY