Nerve repair membrane and preparation method and applications thereof

Abstract

The invention relates to a nerve repair membrane and a preparation method and applications thereof. The nerve repair membrane comprises a lactide-caprolactone copolymer fiber membrane and a polypyrrole coating spread on the lactide-caprolactone copolymer fiber membrane. The method comprises the following steps: (1) dissolving lactide-caprolactone copolymer in a solvent to obtain an electrospinningstock solution; (2) carrying out electrostatic spinning operation on the electrospinning stock solution to obtain the lactide-caprolactone copolymer fiber membrane; and (3) spreading polypyrrole on the lactide-caprolactone copolymer fiber membrane to obtain the nerve repair membrane. The nerve repair membrane has excellent repair effect on injured nerves, and is strong in processability and proper in degradation rate.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a nerve repair membrane and its preparation method and application. Background technique [0002] Peripheral nerve injury is a common disabling condition in humans, often resulting in loss of mobility and sensory impairment. Today's clinical treatment has applied various methods to the treatment to restore the loss of function. End-to-end splices can be used for short nerve injuries, whereas for distant nerve deficits a nerve graft is needed to bridge the transected nerve. Nerve autografting is currently the clinical standard for treating peripheral nerve injuries with a gap of 5-10 mm, however this approach requires removal of a segment of the nerve from a secondary site in the body, which causes additional surgical pain, as well as sensory function at the donor site lost. Furthermore, disadvantages such as limited donor resources, insufficient donor ...

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Problems solved by technology

The obtained nano-polypyrrole chitin nerve guide has good electrical conductivity and controllable degradation, but its flexibility and hydrophilicity are poor, it is difficult to process later, and the nerve repair effect is not good

[0005] CN108503768A discloses a degradable polyurethane socket for nerve repair, the nerve repair socket is better combined with the slow-release layer, not only has good elasticity and high strength, but also the nerve growth factor or brain-derived nerve in the slow-release layer Growth factors can be used for suturing small gaps in nerves, improve the repair of nerve defects, and provide long-term stimulating factors and nutrients for nerve regeneration; in addition, using biodegradable materials with good biocompatibility, after implantation It can avoid or eliminate side effects such as inflammation, meet the requirements of biomedicine, and can be absorbed or excreted by the body without secondary surgery to remove it. However, the elec

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