Nerve repair membrane and preparation method and applications thereof

A nerve repair and equipment technology, which is applied in textiles and papermaking, medical science, fiber processing, etc., can solve the problems of poor electrical conductivity of nerve repair cannula, poor electrical conductivity of composite nerve catheter, and poor nerve repair effect, and achieves the realization of Directed growth, excellent repair effect, good electrical conductivity

Active Publication Date: 2019-06-07
宁波光远致信生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The obtained nano-polypyrrole chitin nerve guide has good electrical conductivity and controllable degradation, but its flexibility and hydrophilicity are poor, it is difficult to process later, and the nerve repair effect is not good
[0005] CN108503768A discloses a degradable polyurethane socket for nerve repair, the nerve repair socket is better combined with the slow-release layer, not only has good elasticity and high strength, but also the nerve growth factor or brain-derived nerve in the slow-release layer Growth factors can be used for suturing small gaps in nerves, improve the repair of nerve defects, and provide long-term stimulating factors and nutrients for nerve regeneration; in addition, using biodegradable materials with good biocompatibility, after implantation It can avoid or eliminate side effects such as inflammation, meet the requirements of biomedicine, and can be absorbed or excreted by the body without secondary surgery to remove it. However, the elec

Method used

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  • Nerve repair membrane and preparation method and applications thereof
  • Nerve repair membrane and preparation method and applications thereof
  • Nerve repair membrane and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] This embodiment provides a nerve repair membrane, which is prepared by the following method:

[0061] (1) Preparation of electrospinning stock solution:

[0062] The lactide-caprolactone copolymer (M w =270000) was dissolved in hexafluoroisopropanol to obtain an electrospinning stock solution whose mass fraction of lactide-caprolactone copolymer was 20%;

[0063] (2) Preparation of fiber membrane:

[0064] Inject the electrospinning stock solution into the syringe, inject the electrospinning stock solution at a speed of 2mL / h under the action of the propulsion pump of the electrospinning equipment, and perform electrospinning under a loading voltage of 15kV, and use a metal rotating receiving plate to receive the electrospinning stock solution. The lactide-caprolactone copolymer fiber film obtained by electrospinning, and the lactide-caprolactone copolymer fiber film was placed in a vacuum drying oven to dry for 40h, and the finally obtained lactide-caprolactone The ...

Embodiment 2

[0069] The difference from Example 1 is that the electrospinning stock solution with a mass fraction of lactide-caprolactone copolymer prepared in step (1) is 15%, and the lactide-caprolactone copolymer obtained in step (2) The diameter of the electrospun fibers in the biofibrous membrane is 0.5 μm.

Embodiment 3

[0071] The difference from Example 1 is that the electrospinning stock solution with a mass fraction of lactide-caprolactone copolymer prepared in step (1) is 30%, and the lactide-caprolactone copolymer obtained in step (2) The diameter of the electrospun fibers in the biofibrous membrane is 2.5 μm.

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Abstract

The invention relates to a nerve repair membrane and a preparation method and applications thereof. The nerve repair membrane comprises a lactide-caprolactone copolymer fiber membrane and a polypyrrole coating spread on the lactide-caprolactone copolymer fiber membrane. The method comprises the following steps: (1) dissolving lactide-caprolactone copolymer in a solvent to obtain an electrospinningstock solution; (2) carrying out electrostatic spinning operation on the electrospinning stock solution to obtain the lactide-caprolactone copolymer fiber membrane; and (3) spreading polypyrrole on the lactide-caprolactone copolymer fiber membrane to obtain the nerve repair membrane. The nerve repair membrane has excellent repair effect on injured nerves, and is strong in processability and proper in degradation rate.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a nerve repair membrane and its preparation method and application. Background technique [0002] Peripheral nerve injury is a common disabling condition in humans, often resulting in loss of mobility and sensory impairment. Today's clinical treatment has applied various methods to the treatment to restore the loss of function. End-to-end splices can be used for short nerve injuries, whereas for distant nerve deficits a nerve graft is needed to bridge the transected nerve. Nerve autografting is currently the clinical standard for treating peripheral nerve injuries with a gap of 5-10 mm, however this approach requires removal of a segment of the nerve from a secondary site in the body, which causes additional surgical pain, as well as sensory function at the donor site lost. Furthermore, disadvantages such as limited donor resources, insufficient donor ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/16A61L27/18A61L27/50A61L27/58D01D5/00
Inventor 韩志超许杉杉张诺滋
Owner 宁波光远致信生物科技有限公司
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