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Minimal hepatic encephalopathy intestinal flora regulating Chinese herbal preparation and preparation method thereof

A micro-liver and intestinal flora technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as lack of obvious curative effect, and achieve promotion of defecation, acceleration of intestinal peristalsis, and improvement of intestinal The effect of dysbiosis

Inactive Publication Date: 2019-06-21
广西中医药大学附属瑞康医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, some scholars have carried out clinical research on the treatment of MHE with traditional Chinese medicine preparations using intestinal flora, but the curative effect is not obvious. The production of gut-derived endotoxin, the synthesis of vitamins needed by the body, stimulates the body’s immunity, thereby effectively maintaining the intestinal mucosal barrier, reducing bacterial translocation and endotoxin production, protecting the liver and nervous system, and reducing the occurrence of hepatic encephalopathy

Method used

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  • Minimal hepatic encephalopathy intestinal flora regulating Chinese herbal preparation and preparation method thereof
  • Minimal hepatic encephalopathy intestinal flora regulating Chinese herbal preparation and preparation method thereof
  • Minimal hepatic encephalopathy intestinal flora regulating Chinese herbal preparation and preparation method thereof

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Effect test

Embodiment 1

[0035] The traditional Chinese medicine preparation for regulating the intestinal flora of mild hepatic encephalopathy is mainly made of the following materials in parts by weight: 16 parts of kudzu root, 18 parts of coptis, 11 parts of red date, 5 parts of honeysuckle, 13 parts of red ginseng, 14 parts of coix seed, 6 parts of Ginsenosides, 10 parts of astragalus polysaccharide, 15 parts of Jiaogulan, 10 parts of clove tea extract, 5 parts of white peony, 7 parts of licorice, 5 parts of celery, 0.4 part of timosaponin, 0.8 part of catechin, 0.6 part of apigenin, 7 parts Evodia, 6 parts Brucea javanica, 12 parts lobelia, 5 parts retroflexus, 11 parts frankincense, 5 parts eucalyptus honey, 3 parts lichen.

[0036] The preparation method of the traditional Chinese medicine preparation for regulating the intestinal flora of mild hepatic encephalopathy comprises the following steps:

[0037] 1) Pueraria root, coptis, red date, honeysuckle, red ginseng, coix seed, ginsenoside, ast...

Embodiment 2

[0043] The traditional Chinese medicine preparation for regulating the intestinal flora of mild hepatic encephalopathy is mainly made of the following materials in parts by weight: 20 parts of kudzu root, 21 parts of coptis, 15 parts of red date, 8 parts of honeysuckle, 17 parts of red ginseng, 15 parts of coix seed, 9 parts of Ginsenosides, 15 parts of astragalus polysaccharide, 19 parts of Jiaogulan, 12 parts of clove tea extract, 17 parts of white peony root, 9 parts of licorice, 8 parts of celery, 0.8 part of timosaponin, 1.2 parts of catechin, 0.9 part of apigenin, 8 parts Evodia, 12 parts Brucea javanica, 13 parts lobelia, 8 parts retroflexus, 19 parts frankincense, 12 parts eucalyptus honey, 10 parts lichen.

[0044] The preparation method of the traditional Chinese medicine preparation for regulating the intestinal flora of mild hepatic encephalopathy comprises the following steps:

[0045] 1) Pueraria root, coptis, red date, honeysuckle, red ginseng, coix seed, ginsen...

Embodiment 3

[0050] The traditional Chinese medicine preparation for regulating the intestinal flora of mild hepatic encephalopathy is mainly made of the following materials in parts by weight: 31 parts of kudzu root, 25 parts of coptis, 17 parts of red date, 10 parts of honeysuckle, 21 parts of red ginseng, 18 parts of coix seed, 12 parts of Ginsenosides, 20 parts of astragalus polysaccharide, 22 parts of Jiaogulan, 15 parts of clove tea extract, 30 parts of white peony, 15 parts of licorice, 10 parts of celery, 1.2 parts of timosaponin, 2 parts of catechin, 1.2 parts of apigenin, 10 parts Evodia, 15 parts Brucea javanica, 15 parts lobelia, 10 parts retroflexus, 24 parts frankincense, 18 parts eucalyptus honey, 17 parts lichen.

[0051] The preparation method of the traditional Chinese medicine preparation for regulating the intestinal flora of mild hepatic encephalopathy comprises the following steps:

[0052] 1) Pueraria root, coptis, red date, honeysuckle, red ginseng, coix seed, ginse...

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Abstract

The invention belongs to the field of drug processing and particularly relates to a minimal hepatic encephalopathy intestinal flora regulating Chinese herbal preparation and a preparation method thereof. The minimal hepatic encephalopathy intestinal flora regulating Chinese herbal preparation is mainly composed of kudzuvine root, coptis chinensis, red date, honeysuckle, red ginseng, semen coicis,ginsenoside, astragalus polysaccharides, gynostemma pentaphylla, clove tea extract, radix paeoniae alba, liquorice, eryngo, timosaponin, catechinic acid, apigenin, fructus evodiae, brucea javanica, lobelia chinensis, amaranthus retroflexus, frankincense, eucalyptus honey and lichen. The minimal hepatic encephalopathy intestinal flora regulating Chinese herbal preparation can accelerate intestinalperistalsis and promote defecation; during defecation, intestinal pernicious bacteria and unhealthy metabolites are excreted to improve intestinal flora disequilibrium; contained organic acids maintain an acid intestinal environment and reduce the pH of intestinal tracts to provide a suitable growing environment for intestinal probiotics. The minimal hepatic encephalopathy intestinal flora regulating Chinese herbal preparation can inhibit bacteria by damaging cytoderm synthesis, protein synthesis and genetic material synthesis of the bacteria.

Description

[0001] 【Technical field】 [0002] The invention belongs to the field of pharmaceutical processing, and in particular relates to a traditional Chinese medicine preparation and a preparation method for regulating intestinal flora of mild hepatic encephalopathy. [0003] 【Background technique】 [0004] Minimal hepatic encephalopathy (MHE), formerly known as recessive or subclinical hepatic encephalopathy, refers to the absence of obvious clinical manifestations and biochemical abnormalities, and can only be detected by fine intelligence tests and (or) electrophysiological tests. Hepatic encephalopathy can only be diagnosed. MHE is a common complication of liver cirrhosis. Foreign reports have shown that the incidence of MHE in patients with liver cirrhosis is 30%-84%. The intelligence test of 409 patients with liver cirrhosis in China found the incidence of MHE. The rate reached 51.3%. MHE patients have a strong hidden condition, neurocognitive dysfunction, and reduced operating ...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P1/00A61P1/16A61P25/00A61K31/352A61K31/353A61K31/715
Inventor 付蕾姚春王清碧
Owner 广西中医药大学附属瑞康医院
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