A kind of porous bone repair scaffold material and preparation method thereof

A scaffold material and porous bone technology, applied in the field of biomedical composite materials, can solve the problems of poor mechanical properties of bone scaffold materials, affecting biocompatibility, insoluble in water, etc., and achieve high toughness, strength and good biocompatibility , Reduce the effect of the process link
CN109908405BActive Publication Date: 2020-07-03NORTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NORTHWEST UNIV
Publication Date
2020-07-03

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Abstract

The invention discloses a porous bone repair scaffold material. The porous bone repair scaffold material is prepared by cross-linking reaction of human-like collagen and sub-nanometer hydroxyapatite under the action of a cross-linking agent. The cross-linking The agent is Agaricus bisporus polyphenol oxidase, the mass ratio of human-like collagen and sub-nanometer hydroxyapatite is 1: (2-5), and the dosage of Agaricus bisporus polyphenol oxidase is 400-1000U / g. In addition, the invention also discloses a preparation method of porous bone repair scaffold material. The invention uses Agaricus bisporus polyphenol oxidase as a cross-linking agent, sub-nanometer hydroxyapatite prepared by mineralization using human-like collagen as a template as an inorganic phase, human-like collagen as an organic phase, and added lecithin and Cell growth factor, the porous bone repair scaffold material prepared by enzymatic cross-linking technology does not require the removal of cross-linking agent residues, has good biocompatibility, and the scaffold material can be reused as a raw material for new bone formation after degradation.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical composite materials, and in particular relates to a porous bone repair scaffold material and a preparation method thereof. Background technique

[0002] Due to the increasing number of traffic accidents, bone injury diseases caused by sports trauma, and bone defects caused by bone necrosis, joint necrosis, trauma, infection, tumor resection, etc., plus in plastic surgery, maxillofacial repair and other operations, the The demand for bone scaffold materials is increasing day by day. As an implantable bone scaffold material, in order to facilitate the adhesion, proliferation and differentiation of cells, and to guide the growth of blood vessels, it has high biological activity and does not cause immune rejection of the body. It not only needs to have a three-dimensional penetrating microarchitecture and a suitable pore size, but also needs to have a microenvironment similar to that of natural bo...

Claims

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