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Platinum@polydopamine-dihydroporphin nano composite material and preparation method and application thereof

A nanocomposite material, polydopamine technology, applied in the field of biomedicine, can solve the problem of lack of hypoxia in tumor sites, etc., to achieve the effect of increasing saturated oxygen concentration, enhancing effect, and increasing production

Active Publication Date: 2019-08-09
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a lack of a material that can effectively solve the problem of hypoxia in tumor sites.

Method used

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  • Platinum@polydopamine-dihydroporphin nano composite material and preparation method and application thereof
  • Platinum@polydopamine-dihydroporphin nano composite material and preparation method and application thereof
  • Platinum@polydopamine-dihydroporphin nano composite material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Step 1. Synthesis of Pt nanoparticles: At room temperature, 200 mg of cetyltrimethylammonium bromide (CTAB) and 10 mg of chloroplatinic acid (H 2 PtCl 6 ) was dissolved in 25mL of water, mixed well, then 25mg of ascorbic acid (AA) was added, stirred for 10min, and finally placed in an oven at 90°C for 12h, the product was centrifuged and dissolved in 10mL of ultrapure water for later use to obtain 20~ 30nm brown-black nano-Pt solution;

[0027] Step 2. Synthesis of Pt@PDA: Dissolve 5 mL of Pt solution and 15 mg of dopamine hydrochloride in 20 mL of ultrapure water at room temperature, and then add 5 mL of 1.5 mM ferric chloride hexahydrate solution (FeCl 3 ·6H 2 O) solution, stirred for 1h, finally added 7.5mL, 30mM Tris buffer solution, and continued to stir for 1h to form Pt@PDA with a core-shell structure, and the thickness of the PDA layer was 10-20 nm, such as figure 1 shown. The product was centrifuged and washed three times with ultrapure water and dissolved ...

Embodiment 2

[0031] The synthesis of Pt nanoparticles refers to Example 1. At room temperature, dissolve 5 mL of Pt solution and 15 mg of dopamine hydrochloride in 20 mL of ultrapure water, stir for 1 h, then add 7.5 mL of 30 mM Tris buffer solution, continue stirring for 1 h, and centrifuge and wash the product three times with ultrapure water (10000 rpm, 10 min ) and dissolved in a certain volume of ultrapure water for collection. No FeCl added 3 ·6H 2 O solution, dopamine grows by self-nucleation and oxidative polymerization, and finally generates micron-scale spherical structures instead of covering the surface of Pt.

Embodiment 3

[0033] The synthesis of Pt nanoparticles refers to Example 1. Dissolve 2 mL of Pt solution and 15 mg of dopamine hydrochloride in 20 mL of ultrapure water at room temperature, then add 5 mL of 1.5 mM FeCl 3 ·6H 2 O solution, stirred for 1 h, finally added 7.5 mL, 30 mM Tris buffer solution, continued to stir for 1 h, the product was washed three times with ultrapure water (10000 rpm, 10 min) and dissolved in a certain volume of ultrapure water to collect. Insufficient Pt content, excessive dopamine will generate separate PDA balls, which will reduce the proportion of Pt@PDA in the core-shell structure, and at the same time catalyze H 2 o 2 Oxygen production is also reduced.

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Abstract

The invention provides a platinum@polydopamine-dihydroporphin nano composite material. The surface of platinum is coated with polydopamine to form a core-shell structure, and dihydroporphin is loadedas a photosensitizer. The composite material has low toxicity, significant biocompatibility and good biodegradability, and can be used as a photothermal therapy reagent and a photodynamic therapy reagent. Besides, Pt can assist in the photodynamic therapy process, relieve the problem of oxygen deficit of a tumor part and finally achieve the PTT-PDT synergistic treatment effect. The invention alsodiscloses a preparation method and application of the composite material.

Description

technical field [0001] The invention relates to a nanocomposite material, specifically a platinum@polydopamine-chlorin nanocomposite material, which belongs to the field of biomedicine. Background technique [0002] Photodynamic therapy is the use of photosensitizer molecules to convert molecular oxygen into toxic singlet oxygen under the irradiation of laser light of suitable wavelength, so as to achieve the killing effect on tumor cells, because of its low systemic toxicity, initial resistance and minimally invasive It has received widespread attention as a potential cancer treatment modality. Oxygen plays a crucial role in the photodynamic process. [0003] In tumor tissue, tumor cells proliferate uncontrollably, and the blood oxygen content and nutrients provided by the vasculature cannot meet their growth needs, resulting in the consumption of oxygen in tumor tissue being far greater than the supply, and the oxygen content continues to decline. And then form the hypox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K47/34A61P35/00
CPCA61K41/0071A61K41/0052A61K9/5146A61K9/5115A61P35/00A61K2300/00
Inventor 沈清明马文康赵红海孙志权范曲立
Owner NANJING UNIV OF POSTS & TELECOMM
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