Platinum@polydopamine-dihydroporphin nano composite material and preparation method and application thereof
A nanocomposite material, polydopamine technology, applied in the field of biomedicine, can solve the problem of lack of hypoxia in tumor sites, etc., to achieve the effect of increasing saturated oxygen concentration, enhancing effect, and increasing production
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Embodiment 1
[0026] Step 1. Synthesis of Pt nanoparticles: At room temperature, 200 mg of cetyltrimethylammonium bromide (CTAB) and 10 mg of chloroplatinic acid (H 2 PtCl 6 ) was dissolved in 25mL of water, mixed well, then 25mg of ascorbic acid (AA) was added, stirred for 10min, and finally placed in an oven at 90°C for 12h, the product was centrifuged and dissolved in 10mL of ultrapure water for later use to obtain 20~ 30nm brown-black nano-Pt solution;
[0027] Step 2. Synthesis of Pt@PDA: Dissolve 5 mL of Pt solution and 15 mg of dopamine hydrochloride in 20 mL of ultrapure water at room temperature, and then add 5 mL of 1.5 mM ferric chloride hexahydrate solution (FeCl 3 ·6H 2 O) solution, stirred for 1h, finally added 7.5mL, 30mM Tris buffer solution, and continued to stir for 1h to form Pt@PDA with a core-shell structure, and the thickness of the PDA layer was 10-20 nm, such as figure 1 shown. The product was centrifuged and washed three times with ultrapure water and dissolved ...
Embodiment 2
[0031] The synthesis of Pt nanoparticles refers to Example 1. At room temperature, dissolve 5 mL of Pt solution and 15 mg of dopamine hydrochloride in 20 mL of ultrapure water, stir for 1 h, then add 7.5 mL of 30 mM Tris buffer solution, continue stirring for 1 h, and centrifuge and wash the product three times with ultrapure water (10000 rpm, 10 min ) and dissolved in a certain volume of ultrapure water for collection. No FeCl added 3 ·6H 2 O solution, dopamine grows by self-nucleation and oxidative polymerization, and finally generates micron-scale spherical structures instead of covering the surface of Pt.
Embodiment 3
[0033] The synthesis of Pt nanoparticles refers to Example 1. Dissolve 2 mL of Pt solution and 15 mg of dopamine hydrochloride in 20 mL of ultrapure water at room temperature, then add 5 mL of 1.5 mM FeCl 3 ·6H 2 O solution, stirred for 1 h, finally added 7.5 mL, 30 mM Tris buffer solution, continued to stir for 1 h, the product was washed three times with ultrapure water (10000 rpm, 10 min) and dissolved in a certain volume of ultrapure water to collect. Insufficient Pt content, excessive dopamine will generate separate PDA balls, which will reduce the proportion of Pt@PDA in the core-shell structure, and at the same time catalyze H 2 o 2 Oxygen production is also reduced.
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