Pharmaceutical composition for treating and preventing obesity and non-alcoholic fatty liver disease

A non-alcoholic, fatty liver technology, applied in the hawthorn flavonoid-total tanshinone composition, the application field in the preparation of drugs and/or health care products for preventing and/or treating non-alcoholic fatty liver, can solve the problem of uneconomical, easy-to-obtain, The efficacy of synergistic gain needs to be studied, and the treatment effect of a single component is not discussed, so as to achieve the effect of streamlining raw materials, relieving excessive weight gain, and reducing fat accumulation in liver tissue

Inactive Publication Date: 2019-08-16
阎永平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2) Raw materials are mostly used, and then boiled and decocted; no extraction and refining steps are included, and potential liver and kidney toxicity cannot be avoided
4) Only the overall efficacy of the composition is ve

Method used

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  • Pharmaceutical composition for treating and preventing obesity and non-alcoholic fatty liver disease
  • Pharmaceutical composition for treating and preventing obesity and non-alcoholic fatty liver disease
  • Pharmaceutical composition for treating and preventing obesity and non-alcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0062] Example 1 Hawthorn flavone-total tanshinone is used to prevent and treat non-alcoholic fatty liver and obesity caused by a high-fat diet model

[0063] 1. Instruments and materials

[0064] Main instruments: electronic balance (Shanghai METTLER TOLEDO); full-wavelength microplate reader (U.S. Thermo company); centrifuge (German Eppendorf company); low-speed desktop centrifuge (KTU Zhongjia).

[0065] Drugs and reagents: 60% high-fat feed (TP2330055A) and its control feed (TP 2330055AC, Nantong Trofe Feed Technology Co., Ltd.); 80% hawthorn flavone, 40% total tanshinone (Shaanxi Senlang Biochemical Co., Ltd.); ALT , AST, TC, TG detection kits (Nanjing Jiancheng Institute of Biological Engineering); other reagents are analytical pure.

[0066] 2. Preparation of hawthorn flavone-total tanshinone composition

[0067] According to the dosage, hawthorn flavonoids are 50 and 100 mg / kg; total tanshinone is 50 and 100 mg / kg. The estimated dosage of the purchased product is: 80% hawthorn...

Example Embodiment

[0093] Example 2: Preparation of tablets and capsules containing 11-99% hawthorn flavone-total tanshinone:

[0094] Take hawthorn flavone-total tanshinone dry powder, pass through a 60-100 mesh sieve for use. (1) Add one or more of the commonly used auxiliary materials for tablets; compressed into tablets by a tablet press. Make each tablet contain no less than 110mg, and the tablet weight can be adjusted according to the drug loading.

[0095] (2) Add one or more common auxiliary materials for capsules, granulate, sizing, and encapsulate. Each capsule contains no less than 110mg of components, and the capsule weight can be adjusted according to the drug loading. See Table 5. Suggested dosage: 6 pills per day, 2 pills / meal, 110-220mg extract / grain; daily intake is 660-1320mg. Or take 3 capsules per day, 1 capsule / meal, 220-440mg extract / cap; daily intake is 660-1320mg. Or take 2 capsules once a day, 2 capsules / meal, 330-660mg extract / capsule; daily intake is 660-1320mg. Accor...

Example Embodiment

[0105] Example 3: Preparation of granules and suspensions containing 3-99% hawthorn flavone-total tanshinone: taking 10 g / bag as an example, the specific dosage form specification (weight / bag) can be adjusted according to the drug loading. Take hawthorn flavone-total tanshinone dry powder, pass through a 60-100 mesh sieve for use. Take 330-1320g of the above-mentioned dry powder and mix any auxiliary materials of 8680-9670g to make the total weight 10000g. Add a small amount of solvent and mix well to make granules, dry, and pack one bag per 10g; a total of 1000 bags. The auxiliary materials include, but are not limited to: sweeteners, powdered sugar, dextrin, β-cyclodextrin and effervescent disintegrants. The prepared hawthorn flavonoids-total tanshinone granules contain 3.3-13.2% of active ingredients in each bag. Recommended dosage: Take 1-2 sachets a day, and the daily intake is 660-1320mg. See Table 6. In consideration of different dosage forms, it is calculated that t...

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Abstract

The invention belongs to the field of medicine. The invention relates to a hawthorn flavone-total tanshinone composition and an application thereof in preparation of drugs and/or health care productsfor preventing and/or treating non-alcoholic fatty liver. The invention also provides an application of the hawthorn flavone-total tanshinone composition in health care products, and drinks prepared by taking the hawthorn flavone-total tanshinone composition as an active ingredient and mixing with food acceptable additives; the invention provides but is not limited to alcoholic blended drinks, fruit beer drinks, added type grape wine, flavored grape wine drinks and the like. The hawthorn flavone-total tanshinone composition is found out to be able to prevent and treat non-alcoholic fatty liver, obesity and hyperlipidemia caused by long-term feeding with high-fat feeds. The oxidation resistance of hawthorn and the lipid-lowering effect of salvia miltiorrhiza are fully combined, all pathological indicators are improved comprehensively, and the non-alcoholic liver disease and obesity are alleviated. The composition is relatively simple, the dosage is relatively low, and the adverse reactions and the burden of liver and kidney are obviously reduced.

Description

technical field [0001] The invention belongs to the field of medicine. Composition and application related to hawthorn flavonoids and total tanshinone. More specifically, it relates to hawthorn flavonoids-total tanshinone composition and its application in the preparation of drugs and / or health products for the prevention and / or treatment of non-alcoholic fatty liver; / or application in medicines and / or health care products for the treatment of obesity. The above-mentioned extracts can be obtained by different processes. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) refers to a syndrome characterized by excessive fat deposition in liver cells caused by alcohol and other definite liver damage factors; including simple fatty liver, fatty liver hepatitis and its associated cirrhosis. With the improvement of per capita living standards, NAFLD has become an important cause of chronic liver disease in Europe, America and my country. The prevalence of ...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61P3/04A61P1/16C12G3/055C12G1/00C12C5/02
CPCA23V2002/00A61K36/537A61K36/734A23L33/105C12C5/02C12G1/00C12G3/04A61K2300/00A23V2200/32A23V2200/332A23V2250/2116A23V2250/5118A23V2250/51084A23V2250/51082A23V2250/51088A23V2250/5112A23V2250/5114A23V2250/612
Inventor 胡冰芳
Owner 阎永平
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