Temperature/pH double-sensitive high-strength nano composite hydrogel and preparation method thereof

A nanocomposite and hydrogel technology, applied in the field of hydrogel preparation, can solve the problems of inability to respond quickly to the environment, low mechanical strength, weak interaction, etc., and achieve simple mixing and heat dissipation, high tolerance, and easy operation Effect

Active Publication Date: 2019-08-16
山东佳诺检测股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the temperature/pH sensitive hydrogels developed and prepared mainly include chemically cross-linked hydrogels and physically cross-linked hydrogels. Their sensitivity has a certain delay and cannot respond quickly to changes in the environment. Moreover, although the chemically crosslinked hydrogel has high mechanical strength, the use of chemical crosslinking agents often makes it have certain biological toxicity, which grea

Method used

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  • Temperature/pH double-sensitive high-strength nano composite hydrogel and preparation method thereof
  • Temperature/pH double-sensitive high-strength nano composite hydrogel and preparation method thereof
  • Temperature/pH double-sensitive high-strength nano composite hydrogel and preparation method thereof

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preparation example Construction

[0090]The invention also discloses a method for preparing a temperature / pH dual-sensitive high-strength nanocomposite hydrogel, and the specific steps include:

[0091] (1) Preparation of ascidian nanocellulose (TCNCs): isolate tunicin from true ascidian, hydrolyze with sulfuric acid, centrifuge after standing for a period of time, and then dialyze to neutral with deionized water to obtain uniform ascidian nanocellulose. Cellulose suspension, then the ascidian nanocellulose suspension prepared is lyophilized with a freeze dryer to obtain the described ascidian nanocellulose (TCNCs) of dry white floc;

[0092] (2) Preparation of ascidian nanocellulose (TCNCs) suspension: uniformly disperse the ascidian nanocellulose (TCNCs) prepared in step (1) in deionized water at room temperature to prepare ascidian nanocellulose suspensions with different mass fractions ;

[0093] (3) Cross-linking reaction mixture: hydroxypropyl methylcellulose (HPMC) is uniformly dispersed in the ascidia...

Embodiment 1

[0103] A method for preparing a temperature / pH dual-sensitive high-strength nanocomposite hydrogel, specifically comprising the following steps:

[0104] In step (1), the tunicin is separated from the true sea squirt, hydrolyzed with an acid, centrifuged after standing for a period of time, and then dialyzed to neutrality with deionized water to obtain a uniform sea squirt nanocellulose suspension.

[0105] In step (2), the ascidian nanocellulose suspension prepared in step (1) is freeze-dried with a freeze dryer to obtain dry white flocculent ascidian nanocellulose (TCNCs).

[0106] In step (3), at room temperature, 0.05 g of the freeze-dried TCNCs prepared in step (2) was dissolved in 4 mL of deionized water, stirred overnight and ultrasonicated for 10 min to prepare a uniform TCNCs suspension.

[0107] In step (4), 0.3 g of HPMC is added into the system of step (3), stirred and mixed evenly.

[0108] In step (5), monomer PEGMA and monomer AAc (mass ratio: 70:30) are sequen...

Embodiment 2

[0116] As described in Example 1, the difference is that the quality of TCNCs is changed to 0.15g, and other preparation process conditions and process parameters remain unchanged, and a nanocomposite hydraulic gel with high-efficiency temperature / pH dual sensitivity and high strength is prepared. glue.

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Abstract

The invention discloses a temperature/pH double-sensitive high-strength nano composite hydrogel and a preparation method thereof. The preparation method comprises the following steps: (1) separating tunicin from Halocynthia roretzi Drasche and performing acidolysis on the tunicin to obtain tunicate nano cellulose (TCNCS); (2) adding hydroxypropyl methylcellulose (HPMC), polyethylene glycol methacrylate (PEGMA) and acrylic acid (AAC) into TCNCS suspension, mixing with an initiator, and placing the mixture in a constant temperature water bath to react for 24h to obtain the nano composite hydrogel product, and freeze-drying to obtain a solid product. The reaction is easy to operate and has mild conditions; and the nano composite hydrogel prepared by the preparation method has high-efficiencytemperature/pH double sensitivity and high strength, has good biocompatibility at the same time, and has wide application prospects in aspects of drug release systems, disease diagnosis, daily monitoring and the like in medical treatment and medicine fields.

Description

technical field [0001] The invention belongs to the technical field of hydrogel preparation, and relates to a nanocomposite hydrogel with high-efficiency temperature / pH dual sensitivity and high strength and a preparation method thereof. Background technique [0002] Smart hydrogel refers to a type of hydrogel that changes the properties of the gel when the external environment changes (such as temperature, pH value, electric field, solvent properties, light intensity and wavelength, pressure, ionic strength, etc.). Due to their unique responsiveness, such hydrogels have broad application prospects in sensors, drug delivery, tissue engineering, and enzyme immobilization, among which temperature- and pH-sensitive hydrogels are the most important and widely studied. Two smart hydrogels. [0003] Temperature-sensitive hydrogels can change their properties (such as swelling degree, light transmittance, etc.) with the change of external temperature. The polymer chains of such hy...

Claims

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Application Information

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IPC IPC(8): C08F251/02C08F283/06C08F220/06
CPCC08F251/02C08F283/065C08F220/06
Inventor 车玉菊岳珍孟凡君马庆林
Owner 山东佳诺检测股份有限公司
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