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Injectable and rapidly-gelatinized composite hydrogel and preparation method thereof

A composite hydrogel and gelation technology, used in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve problems such as easy shedding, poor degradability of gel dressings, and poor adhesion between hydrogels and wounds. Conducive to industrialization and simple process

Inactive Publication Date: 2019-09-06
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of today's hydrogel dressings are gel and applied to the wound. The adhesion between the hydrogel and the wound is poor, and it is easy to fall off, and the hydrogel dressing with a fixed shape will be limited by the wound area and shape; Additionally, most gel dressings are less degradable and have a lower rate of drug release

Method used

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  • Injectable and rapidly-gelatinized composite hydrogel and preparation method thereof
  • Injectable and rapidly-gelatinized composite hydrogel and preparation method thereof
  • Injectable and rapidly-gelatinized composite hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The composite hydrogel of this example is an injectable and rapidly gelling composite hydrogel based on succinyl chitosan-aldehydated hyaluronate, which combines succinyl chitosan and aldhylated hyaluronic acid Based on the excellent characteristics of sodium nitrite, the carbon-nitrogen double bond is formed through the reaction of amino group and aldehyde group, so that the polymer can be cross-linked to obtain an injectable and rapidly gelling composite hydrogel.

[0031] Specifically, the preparation process of the injectable and fast-gelling composite hydrogel of succinyl chitosan-formylated hyaluronic acid of the present embodiment is as follows:

[0032] (1) Preparation of succinyl chitosan

[0033] Dissolve chitosan in an appropriate amount of acetic acid solution with a mass fraction of 3%, then add acetone solution of succinic anhydride, and react with magnetic stirring at room temperature for 6 to 24 hours. pH to 9~11; among them, n(chitosan) / n(succinic anhy...

Embodiment 2

[0056] The composite hydrogel of this example is an injectable and rapidly gelling composite hydrogel based on octylated chitosan-alginylated sodium alginate, which combines octylated chitosan and alginylated alginate Based on the excellent characteristics of sodium nitrite, the carbon-nitrogen double bond is formed through the reaction of amino group and aldehyde group, so that the polymer can be cross-linked to obtain an injectable and rapidly gelling composite hydrogel.

[0057] Specifically, the preparation process of the injectable and rapidly gelling composite hydrogel of octylated chitosan-alginylated sodium alginate is as follows:

[0058] (1) Preparation of Octylated Chitosan

[0059] A certain amount of chitosan is dissolved in an appropriate amount of 3% acetic acid solution, and after being completely dissolved, a certain amount of ethanol is added to make a homogeneous solution, and a certain amount of octanal is added, wherein, n(chitosan) / n( Octanal) is 2:1, 1:...

Embodiment 3

[0069] The composite hydrogel of this example is an injectable and rapidly gelling composite hydrogel based on succinyl chitosan-alginylated sodium alginate, which combines succinyl chitosan and alginylated sodium alginate The excellent characteristics of the compound hydrogel are formed through the reaction of the amino group and the aldehyde group to form a carbon-nitrogen double bond, so that the polymer can be cross-linked to obtain an injectable and fast-gelling composite hydrogel.

[0070] Specifically, the preparation process of the injectable and fast-gelling composite hydrogel of succinyl chitosan-formylated sodium alginate is as follows:

[0071] (1) Preparation of succinyl chitosan

[0072] It is the same as that of Embodiment 1, and will not be repeated here.

[0073] (2) Preparation of alginylated sodium alginate

[0074] It is the same as the second embodiment, and will not be repeated here.

[0075] (3) Preparation of composite hydrogel

[0076] Dissolving s...

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Abstract

The invention belongs to the field of polymer composite hydrogel, and relates to an injectable and rapidly-gelatinized composite hydrogel and a preparation method thereof, wherein the composite hydrogel is formed by crosslinking a water-soluble polymer with an amino group and a water-soluble polymer with an aldehyde group; the composite hydrogel has the pH response characteristics and injectability; the composite hydrogel forms a three-dimensional network structure through the interaction between the amino group and the aldehyde group, various drugs or growth factors and other bioactive molecules can be loaded in the three-dimensional network structure. In addition, the composite hydrogel has injectability, and because the carbon-nitrogen double bond Schiff base linking structure formed bythe amino group and the aldehyde group has pH response characteristics, the composite hydrogel can be used as a polymer hydrogel wound dressing having certain application prospects in the fields of drug releasing, skin wound repair and the like.

Description

technical field [0001] The invention belongs to the field of polymer composite hydrogels, and relates to an injectable and rapid-gelling composite hydrogel and a preparation method thereof. Background technique [0002] The skin is the largest organ of an organism, and its total weight accounts for 5% to 15% of the body weight. It is also the first barrier between the human body and the external environment, preventing the invasion of microorganisms. Regulation, thermoregulation, immune surveillance and self-healing play important roles. Large-area skin defects can cause a series of pathological changes that endanger health, such as metabolic disorders, immune disorders, and electrolyte imbalances. In severe cases, it can lead to shock or even life-threatening. [0003] In order to promote skin wound repair, skin repair dressings need to be covered on the surface of skin wounds to protect the injured area, prevent infection and severe dehydration, and provide a relatively s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/075C08L5/08C08B37/08
CPCC08J3/075C08B37/0072C08B37/003A61L26/0052A61L26/0085A61L26/008C08J2305/08C08J2405/08A61L2400/06C08L5/08
Inventor 江国华朱将赢杨玉慧马翩翩曹聪孔祥东
Owner ZHEJIANG SCI-TECH UNIV
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