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Oral emulsion rich in Omega-3 unsaturated fatty acid and preparation method of oral emulsion

An unsaturated fatty acid and emulsion technology, which is applied in the field of oral milk rich in Omega-3 unsaturated fatty acid and its preparation field, can solve the problems of poor oil solubility, fishy aftertaste, unfavorable absorption, etc., and achieves increased solubility and increased surface area. Great, improve the effect of absorption

Pending Publication Date: 2019-09-17
宁波仙健海嘉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Currently, commercially available health products rich in Omega-3 unsaturated fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) mainly appear in the form of capsules, such as DHA algae oil Soft capsules, fish oil soft capsules, krill oil capsules, etc., but the oil contained in the capsules is not much, and the oil rich in Omega-3 unsaturated fatty acids has poor solubility, which is not conducive to human absorption, and its bioavailability is not high. Not high, affecting the role of the product in assisting the regulation of cardiovascular and cerebrovascular. At the same time, after taking seaweed oil, fish oil, and krill oil capsules, there will be fishy aftertaste, belching, etc., which seriously affects the user's taking experience
There are also related reports on emulsions or liquid beverages such as fish oil and seaweed oil, but their main research components and ratios are not involved in their mechanisms and bioavailability; only a single method is often used for taste masking

Method used

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  • Oral emulsion rich in Omega-3 unsaturated fatty acid and preparation method of oral emulsion
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  • Oral emulsion rich in Omega-3 unsaturated fatty acid and preparation method of oral emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: Preparation of oral emulsion rich in Omega-3 unsaturated fatty acids

[0047] As shown in Table 1 below, the preparation method for preparing an oral emulsion rich in Omega-3 unsaturated fatty acids is as follows:

[0048] 1. Prepare the oil phase: mix seaweed oil or fish oil or krill oil, soybean lecithin, and tocopherol oil phase components evenly under nitrogen protection, and set aside;

[0049] 2. Preparation of water phase: Dissolve sucrose ester and water-soluble raw and auxiliary materials in 1000mL deionized water to form a uniform aqueous solution for later use;

[0050] 3. Preparation of emulsion: Under the protection of nitrogen, the water phase is added to the oil phase by stirring and vortex, and an oil-in-water emulsion is formed by shearing and stirring or high-pressure homogenization, and an oral emulsion with a particle size of less than 500nm is obtained;

[0051] 4. Filtration and packaging: After the nanoemulsion is filtered through a...

Embodiment 2

[0057] Embodiment 2: Antioxidation experiment of oral emulsion rich in Omega-3 unsaturated fatty acids

[0058] 1. Experimental reagents

[0059] Seaweed oil oral emulsion group: adopt the prescription (seaweed oil) of preparation 15 in Example 1 to prepare oral emulsion, volume 10mL; fish oil oral emulsion group: adopt the prescription (fish oil) of preparation 15 in Example 1 to prepare oral emulsion, volume 10mL; Krill oil oral emulsion group: adopt the prescription (krill oil) of preparation 15 in Example 1 to prepare oral emulsion, volume 10mL; Commercially available group: authorized patented milk DHA drink (Zhejiang Jiuxu Pharmaceutical Co., Ltd., CN104719913A )

[0060] Saturated potassium iodide solution: weigh 14g HI, add 10ml of water to dissolve; chloroform-glacial acetic acid mixture: measure 40ml of chloroform, add 60ml of glacial acetic acid, mix well; 0.002mol / l sodium thiosulfate standard solution; 10g / l starch indicator.

[0061] Ethanol-ether mixed soluti...

Embodiment 3

[0068] Example 3: Taste masking technology experiment

[0069] 1. Subjects: 6 volunteers

[0070] 2. The present embodiment is divided into eight groups, and the approach is specifically as follows:

[0071](1) Pure milk group: pure milk (Mengniu Dairy (Group) Co., Ltd.)

[0072] (2) Seaweed oil capsule group: cut open the seaweed oil capsule (Weihai Ziguang Biotechnology Development Co., Ltd.), and take 10 mL of the liquid in the capsule.

[0073] (3) Fish oil capsule group: fish oil capsule (By-Health Co., Ltd.), take 10 mL of the liquid in the capsule.

[0074] (4) Krill oil capsule group: krill oil capsule (Qufu Shengkanglai Health Industry Co., Ltd.), take 10 mL of the liquid in the capsule.

[0075] (5) Naru group: Naru DHA beverage (Zhejiang Jiuxu Pharmaceutical Co., Ltd., CN104719913A) with authorized patent, 10 mL of Naru.

[0076] (6) Seaweed oil oral milk group: adopt the prescription (seaweed oil) of preparation 15 in Example 1, mix evenly under nitrogen protec...

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Abstract

The application of the invention relates to oral emulsion rich in Omega-3 unsaturated fatty acid and a preparation method of the oral emulsion. The oral emulsion comprises 1%-50% of fat rich in Omega-3 unsaturated fatty acid, 0.2%-10% of an emulsifying agent, 0.01%-0.8% of an emulsifying membrane stabilizer, 0.01%-0.6% of an absorption enhancer, 0.01%-0.6% of an antioxidant, 0-40% of raw and auxiliary materials acceptable in other drugs or foods, and 1%-90% of deionized water relative to the total mass of the oral emulsion. The oral emulsion can effectively increase the biological availability of the fat rich in Omega-3 unsaturated fatty acid, promote absorption of small intestine epithelium cells and conceal bad smell of the fat.

Description

technical field [0001] The application relates to the fields of food, health food, special medical food and medicine, and mainly relates to an oral milk rich in Omega-3 unsaturated fatty acids and a preparation method thereof. The oral emulsion described in the application can improve the bioavailability of Omega-3 unsaturated fatty acids and cover the fishy smell of oily substances. Background technique [0002] With the development of social economy, people's living standards have been greatly improved, and the way of life has also undergone tremendous changes. Due to smoking, unreasonable diet, overweight, lack of exercise and other factors, the risk trend of cardiovascular and cerebrovascular diseases in my country is obvious, and the prevalence of cardiovascular and cerebrovascular diseases is on the rise. Drug therapy is the most common treatment for cardiovascular and cerebrovascular diseases. At the same time, adjusting the diet structure in daily life and increasin...

Claims

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Application Information

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IPC IPC(8): A23L33/115A23L29/10A61K9/107A61K31/202A61K36/02A61K35/60A61K35/612A61K47/24A61K47/22A61K47/26A61K47/44A61K47/10A61K47/36A61K47/38A61P7/02A61P3/06A61P9/12A61P9/00A61P9/10
CPCA23L33/115A23L29/10A61K9/1075A61K9/0053A61K31/202A61K36/02A61K35/60A61K35/612A61K47/24A61K47/22A61K47/26A61K47/44A61K47/10A61K47/36A61K47/38A61P7/02A61P3/06A61P9/12A61P9/00A61P9/10A23V2002/00A23V2200/32A23V2200/326A23V2250/186A23V2200/222A23V2200/02A23V2250/5036A23V2250/18A23V2250/51082A23V2250/5086A23V2250/51084A23V2250/5024A23V2250/5026A23V2250/5432A23V2250/511A23V2250/708A23V2250/72A23V2250/1614A23V2200/06A23V2200/3262
Inventor 不公告发明人
Owner 宁波仙健海嘉生物科技有限公司
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