Hemostatic material for nephrology department and preparation method thereof

A hemostatic material and internal medicine technology, applied in the field of medical materials, can solve the hidden dangers of fibrin glue virus, tissue necrosis and other problems, achieve good hemostatic effect, promote the formation of thrombus, and produce low cost effects

Inactive Publication Date: 2019-09-20
孙晓英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These hemostatic materials are widely used in surgical hemostasis, and have achieved certain hemostatic effects in clinical and animal experiments, but they also have certain defects or hidden dangers, such as tissue necrosis caused by zeolite and oxidized regenerated cellulose, and allergic reactions caused by collagen , local adhesions formed by cyanoacrylate, gelatin, cellulose ethers, potential virus hidden dangers of fibrin glue, etc.

Method used

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  • Hemostatic material for nephrology department and preparation method thereof

Examples

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Effect test

Embodiment 1

[0034] A preparation method of a hemostatic material for nephrology, comprising the steps of:

[0035]Step S1 Ionization of epichlorohydrin bis[2-[[4-(2,2-dicyanovinyl)-3-methylphenyl]ethylamino]adipate: 100g of epichlorohydrin 335g of bis[2-[[4-(2,2-dicyanovinyl)-3-methylphenyl]ethylamino]adipate was added to 1200g of dichloromethane and stirred at 30°C After reacting for 6 hours, the dichloromethane was removed by rotary evaporation, and the product was washed 3 times with ether, and then the ether was removed by rotary evaporation to obtain the ionized di[2-[[4-(2,2-dicyanovinyl )-3-methylphenyl]ethylamino]adipate;

[0036] Preparation of step S2 modified cyclodextrin: ionizing epichlorohydrin prepared in step S1 to bis[2-[[4-(2,2-dicyanovinyl)-3-methylphenyl] Add 100g of ethylamino]adipate, 300g of mono-6-O-amino-β-cyclodextrin, and 10g of chlorobenzoquinone into 2000g of N,N-dimethylformamide, and stir the reaction at 60°C for 6 hours, then precipitated in acetone, rem...

Embodiment 2

[0044] A preparation method of a hemostatic material for nephrology, comprising the steps of:

[0045] Step S1 Ionization of epichlorohydrin bis[2-[[4-(2,2-dicyanovinyl)-3-methylphenyl]ethylamino]adipate: 100g of epichlorohydrin 335g of bis[2-[[4-(2,2-dicyanovinyl)-3-methylphenyl]ethylamino]adipate was added to 1350g of ethyl acetate and stirred at 32°C After reacting for 6.5 hours, the ethyl acetate was removed by rotary evaporation, and the product was washed 4 times with ether, and then the ether was removed by rotary evaporation to obtain epichlorohydrin ionized bis[2-[[4-(2,2-dicyanovinyl )-3-methylphenyl]ethylamino]adipate;

[0046] Preparation of step S2 modified cyclodextrin: ionizing epichlorohydrin prepared in step S1 to bis[2-[[4-(2,2-dicyanovinyl)-3-methylphenyl] Add 100g of ethylamino]adipate, 350g of mono-6-O-amino-β-cyclodextrin, and 15g of l,4-naphthoquinone into 2100g of N,N-dimethylformamide, and stir at 65°C Reacted for 6.5 hours, then precipitated in ace...

Embodiment 3

[0054] A preparation method of a hemostatic material for nephrology, comprising the steps of:

[0055] Step S1 Ionization of epichlorohydrin bis[2-[[4-(2,2-dicyanovinyl)-3-methylphenyl]ethylamino]adipate: 100g of epichlorohydrin 335 g of bis[2-[[4-(2,2-dicyanovinyl)-3-methylphenyl]ethylamino]adipate was added to 1500 g of acetone, and the reaction was stirred at 35°C for 7 hours, then remove the acetone by rotary evaporation, and wash the product with ether for 3-5 times, then remove the ether by rotary evaporation to obtain the ionized bis[2-[[4-(2,2-dicyanovinyl)- 3-Methylphenyl]ethylamino]adipate;

[0056] Preparation of step S2 modified cyclodextrin: ionizing epichlorohydrin prepared in step S1 to bis[2-[[4-(2,2-dicyanovinyl)-3-methylphenyl] Add 100g of ethylamino]adipate, 400g of mono-6-O-amino-β-cyclodextrin, and 20g of chlorobenzoquinone into 2300g of N,N-dimethylformamide, and stir the reaction at 70°C for 7 hours, then precipitated in acetone, removed the acetone b...

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Abstract

The invention discloses a preparation method of a hemostatic material for nephrology department, wherein the preparation method includes the following steps: (1) ionization of di[2-[4-(2,2-dicyanovinyl)-3-methylphenyl]ethyl amino]adipate with epoxy chloropropane; (2) preparation of modified cyclodextrin; (3) preparation of modified chitosan; (4) preparation of ethyl-modified dopamine 3-beta-D-sodium glucosiduronate; (5) formation of a hemostatic material substrate; and (6) modification of the hemostatic material substrate. The invention also discloses the hemostatic material used for nephrology department and prepared according to the preparation method of the hemostatic material for nephrology department. The hemostatic material for nephrology department has the advantages of good hemostatic effect, good biocompatibility, high hemostatic efficiency, small side effects and safe use and can promote wound healing.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a hemostatic material for nephrology and a preparation method thereof. Background technique [0002] With the worsening of global environmental problems and the increasing pressure from life and work, more and more people suffer from nephrology diseases. Uremia is one of the more serious nephrology diseases, and it is currently considered It is one of several major diseases that cannot be cured, and its incidence rate is showing a trend of increasing year by year. In order to prolong the patient's life and alleviate the suffering of the patient, this disease has to be treated symptomatically. Currently, the most common form of treatment is hemodialysis. [0003] Hemodialysis is a treatment method to purify the blood of uremia patients with severe renal function loss through a semipermeable membrane, using the principles of diffusion, convection, and adsorption. Throu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00C08B37/16C08B37/08
CPCA61L24/0005A61L24/001A61L24/0015A61L24/0036A61L24/02A61L24/08A61L2300/30A61L2300/418A61L2400/04C08B37/0012C08B37/003C08L1/04C08L5/08C08L5/16
Inventor 孙晓英刘玉新郑玉峰
Owner 孙晓英
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