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Method for extracting pentamethylene diamine with microwaves

A technology of pentamethylenediamine and microwave, which is applied in the field of microwave extraction of pentamethylenediamine, can solve problems such as difficult to obtain high-purity pentamethylenediamine dicarboxylate, and achieve reduced extraction time, good separation effect, and high extraction yield Effect

Active Publication Date: 2019-10-08
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem is that although the impurity inorganic salts are removed before the enzyme conversion, a large amount of carbon dioxide will be generated during the conversion of lysine decarboxylase, forming carbonate ions in the system, and the subsequent separation process does not involve The removal of carbonate ions, experiments have proved that it is difficult to obtain high-purity pentamethylenediamine dicarboxylate in the subsequent crystallization process. Due to the presence of carbonate, the obtained pentamethylenediamine dicarboxylate contains a certain proportion of pentamethylenediamine carbon salt

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the preparation of the system containing pentamethylenediamine

[0041] Take 10L of fermentation broths of lysine sulfate, phosphate, carbonate, and hydrochloride respectively, use lysine decarboxylase to catalyze, and obtain the conversion liquid of pentamethylenediamine salt after sufficient catalysis. Then use sodium alkali, potassium alkali, calcium alkali, magnesium alkali, barium alkali or their respective oxides to adjust the alkali respectively so that the pH is greater than 11.0, and after sufficient stirring, the pentamethylenediamine conversion solution after alkali adjustment with a large amount of inorganic salts can be obtained . Use sodium alkali, potassium alkali and their respective oxides to adjust alkali respectively to obtain pentamethylenediamine feed liquid, which respectively contains a large amount of sodium sulfate, sodium carbonate, potassium sulfate, potassium carbonate, sodium phosphate, potassium phosphate, and sodium chloride ...

Embodiment 2

[0043] Get the aqueous phase 1.0L that contains pentamethylenediamine among the embodiment 1, main composition is: pentamethylenediamine content 120g / kg, total inorganic salt content is 17% by ash content, and inorganic salt main component is sodium sulfate, and the T430nm of feed liquid The light transmittance is 28%, contains a small amount of miscellaneous protein, and the pH of the feed solution is 14.0. Put 1.0L feed liquid in a 2L double-necked flask, and place it in a microwave reaction furnace (including top stirring, adjust the speed to 150-200r / min), one port is connected to the temperature probe, and the other port is connected to a glass elbow to transfer condensation tube, the power of the microwave transmitter is 750W, and the set temperature is 180°C. The vaporized water vapor containing pentamethylenediamine flows out through the condenser tube. After 1 hour, 945mL of condensate is obtained, and the concentration of pentamethylenediamine is 123.4g / L. The yield ...

Embodiment 3

[0045] Get the aqueous phase 1.0L that contains pentamethylenediamine among the embodiment 1, main composition is: pentamethylenediamine content 140g / kg, total inorganic salt content is 2.2% with ash content, inorganic salt main component is calcium sulfate, calcium carbonate, material The T430nm light transmittance of the liquid is 32.5%, contains a small amount of miscellaneous protein, and the pH of the liquid is 11.8. Place 1.0L of feed liquid in a 2L double-necked flask, and place it in a microwave reaction furnace (attached with an ultrasonic emission device, acting on the reaction system), one port is connected to a temperature probe, and the other port is connected to a glass elbow transfer condenser tube, microwave The power of the transmitter is 750W, the set temperature is 130°C, the condensing end is connected to a vacuum pump, and the absolute pressure of the system is kept at 0.1 bar. The vaporized pentamethylenediamine water vapor flows out through the condenser ...

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Abstract

The invention discloses a method for extracting pentamethylene diamine with microwaves. The method is characterized in that a system with pentamethylene diamine is acted with microwaves, so that pentamethylene diamine in the system is volatilized in a gas phase mode, steam with the pentamethylene diamine or a water solution with the pentamethylene diamine can be obtained, and the purpose of separation the pentamethylene diamine can be achieved; and in addition, a pure pentamethylene diamine product or pentamethylene diamine dicarboxylate can be prepared through further purification. The methodhas the beneficial effects that the extraction efficiency of the pentamethylene diamine is high, the extraction yield is high, and separation of the pentamethylene diamine from pigments, impure proteins, inorganic salts, and the like, can be achieved through a one-step method.

Description

technical field [0001] The invention belongs to the field of biochemical industry, and in particular relates to a method for extracting pentamethylenediamine by using microwaves. Background technique [0002] In recent years, there have been many reports on the biological preparation of pentamethylenediamine, and the commonly used method is microbial fermentation. Basically, it can be divided into three steps, (1) fermentative production of lysine: producing lysine with biomass as raw material; (2) fermentation and enzymatic conversion of decarboxylase: using lysine as raw material, making lysine by decarboxylase Amino acid decarboxylation to produce 1,5-pentamethylenediamine; (3) separation, extraction and purification of the product pentanediamine. At present, the cost of preparing pentamethylenediamine is relatively high, and the main problems of the high production cost are the low efficiency of the separation process, low yield and unqualified quality. On the other ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C209/86C07C211/09C07C209/84
CPCC07C209/86C07C209/84C07C211/09
Inventor 应汉杰杨朋朋林晨光温庆仕吴菁岚王骏之朱晨杰陈勇柳东欧阳平凯
Owner NANJING TECH UNIV